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Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice

Article DOI: 10.3791/2968-v • 05:55 min • October 3rd, 2011
October 3rd, 2011 •
1, 1, 2, 1, 3, 3
1Department of Molecular Microbiology and Immunology, Bond Life Sciences Center, University of Missouri, 2Department of Biological Sciences, Columbia University, 3Department of Veterinary Pathobiology, Bond Life Sciences Center, University of Missouri

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This article demonstrates two very different methods of injection: 1) into the brain (intracerebroventricular) and 2) systemic (intravenous) to introduce the therapeutic agents into the central nervous system of neonatal mice.

Tags

Intracerebroventricular Injection Intravenous Injection Therapeutic Agents Blood Brain Barrier Central Nervous System Neurodegenerative Disorders Spinal Muscular Atrophy Neonatal Mice Cerebral Lateral Ventricles Cerebrospinal Fluid Temporal Vein Injection Viral Vector Viral Serotype Systemic Delivery Permeable Blood Brain Barrier
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