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In vitro aggregeringsanalyser Använda hyperfosforylerat Tau-protein

Article DOI: 10.3791/51537-v • 09:22 min • January 2nd, 2015
January 2nd, 2015 •
*1, *1, 1
1Department of Biochemistry and Molecular Biology, Michigan State University
* These authors contributed equally

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Omodifierade och hyperfosforylerat tau-proteiner användes i två in vitro aggregeringsanalyser att avslöja hyperfosforylering beroende snabb aggregering kinetik. Dessa analyser banar väg för framtida skärmar för föreningar som kan modulera benägenhet hyperfosforylerat tau att bilda fibriller som ligger bakom utvecklingen av Alzheimers sjukdom.

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Biokemi tau Alzheimers sjukdom tauopathy fosforylering amyloid blixtlås-Assisted katalys protein aggregering nystan
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