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In Vitro Aggregation Analyser hjelp hyperfosforylert Tau Protein

Article DOI: 10.3791/51537-v • 09:22 min • January 2nd, 2015
January 2nd, 2015 •
*1, *1, 1
1Department of Biochemistry and Molecular Biology, Michigan State University
* These authors contributed equally

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Umodifiserte og hyperfosforylert tau proteiner ble brukt i to in vitro aggregering analyser for å avdekke hyperfosforylering avhengige rask aggregering kinetikk. Disse analysene bane vei for fremtidige skjermer for forbindelser som kan modulerer tilbøyelighet til hyperfosforylert tau for å danne fibriller som ligger til grunn for utviklingen av Alzheimers sykdom.

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Biokjemi tau Alzheimers sykdom tauopati fosforylering amyloid Glidelåser-Assisted Katalyse protein aggregering nevrofibrillære floker
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