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Journal / Bioengineering / Tredimensjonale vev utvikling justert astrocytter …
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Tredimensjonale vev utvikling justert astrocytter nettverk å Recapitulate utviklingsmessige mekanismer og tilrettelegge nervesystemet gjenfødelse
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Tredimensjonale vev utvikling justert astrocytter nettverk å Recapitulate utviklingsmessige mekanismer og tilrettelegge nervesystemet gjenfødelse

Article DOI: 10.3791/55848-v • 08:56 min • January 10th, 2018
January 10th, 2018 •
*1,2,3, *1,2,4, 1,2,4, 1,2, 1,5, 1,5, 1,2,4, 1,2,5
1Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 2Center for Neurotrauma, Neurodegeneration & Restoration, Michael J. Crescenz Veterans Affairs Medical Center, 3School of Biomedical Engineering, Drexel University, 4Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, 5Neuroscience Graduate Group, Perelman School of Medicine, University of Pennsylvania
* These authors contributed equally

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Vi presentere utviklingen av selv montert, tredimensjonal bunter av langs justert astrocytic somata og prosesser i en roman biomateriale encasement. Disse konstruert "levende stillaser", viser mikron skala diameter men utvide centimetere i lengde, kan tjene som test senger å studere neurodevelopmental mekanismer eller lette neuroregeneration av dirigere neuronal overføringen og/eller axonal pathfinding.

Tags

Bioteknologi problemet 131 Neural tissue engineering levende stillaser Biografiske filmer neuroregeneration celle migrasjon axon pathfinding astrocytter nettverk nevrale stamceller
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