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Journal / Cancer Research / Flow cytometri-baserte narkotika Screening System …
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Cancer Research

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Flow cytometri-baserte narkotika Screening System for identifisering av små molekyler som fremmer differensiering av glioblastom stilk celler

Article DOI: 10.3791/56176-v • 10:28 min • January 10th, 2018
January 10th, 2018 •
1, 1, 2, 1,3, 1
1Department of Neurological Surgery, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, 2Department of Pathology, Johns Hopkins University, School of Medicine, 3Department of Neurological Surgery, University Hospital-Case Medical Center, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine

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En effektiv screening protokoll er presentert for identifikasjon av små molekyler som fremmer astroglial differensiering i glioblastom stilk celler (GSCs). Analysen er basert på en stilk cellen differensiering reporter der uttrykket av den forbedrede GFP (eGFP) er drevet av menneskelig GFAP selskapet.

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Kreft biologi problemet 131 stilk celler Glioma Astrocytic differensiering Lentivirus Reporter System narkotika skjermen differensiering terapi Acetyl kolin kalsium signalisering
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