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Induktion af aterosklerotiske Plaques gennem aktivering af Mineralocorticoid receptorer i Apolipoprotein E-mangelfuld mus

Article DOI: 10.3791/58303-v • 07:36 min • September 26th, 2018
September 26th, 2018 •
1, 1, 1, 1, 1,2
1Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Pisana, Rome, Italy, 2Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy

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Vi beskriver en protokol for at fremkalde åreforkalkning i aorta roden af ApoE- / - mus fodret med en atherogene kost, gennem en kontinuerlig frigivelse af aldosteron. Metoder til at karakterisere plaque sammensætning er også beskrevet.

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Medicin sag 139 åreforkalkning aldosteron betændelse ApoE- / - aorta rod Immunohistokemi
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