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Journal / Chemistry / 標的プラスミドDNA送達に対するメチオニン機能性生体適合性共重合体…
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Chemistry

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JoVE Journal Chemistry
標的プラスミドDNA送達に対するメチオニン機能性生体適合性共重合体
Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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標的プラスミドDNA送達に対するメチオニン機能性生体適合性共重合体

Article DOI: 10.3791/58527-v • 08:09 min • August 6th, 2019
August 6th, 2019 •
*1, *2, 2, 3, 2, 3, 1, 2
1Research Center of Clinical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, 2Department of General Surgery, The First Affiliated Hospital with Nanjing Medical University, 3School of Clinical Medicine, Xuzhou Medical University
* These authors contributed equally

Kapitel

Summary
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本研究では、可逆添加断片化鎖伝達(RAFT)法を介したメチオニン機能性生体適合性共重合体(mBG)の調製を提示する。得られたmBGとそのトランスフェクション効率のプラスミドDNA複合能も調べられた。RAFT法は、特殊な官能基を含むモノマーを重合するために非常に有益である。

Tags

化学,問題150,可逆添加断片化鎖転移,RAFT,薬物送達システム,DDS,メチオニン,グアニジン,N-(3-アミノプロピル)塩酸メサクリラム化物,APMA,N,N-bis(2-ヒドロキシエチル) メタクリラム化物 BNHEMA
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