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Journal / Immunology and Infection / 活体细胞毒性试验研究肿瘤特异性 CD8+ t…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
活体细胞毒性试验研究肿瘤特异性 CD8+ t 细胞反应中的免疫调节
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Journal (Immunology and Infection)
Using Zebrafish Models of Human Influenza A Virus Infections to Screen Antiviral Drugs and Characterize Host Immune Cell Responses
 
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活体细胞毒性试验研究肿瘤特异性 CD8+ t 细胞反应中的免疫调节

Article DOI: 10.3791/59531-v • 10:13 min • May 6th, 2019
May 6th, 2019 •
1, 1, 1,2,3,4
1Department of Microbiology and Immunology, Western University, 2Department of Medicine, Division of Clinical Immunology and Allergy, Western University, 3Department of Surgery, Division of General Surgery, Western University, 4Lawson Health Research Institute

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Summary
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我们这里描述了一种基于流式细胞仪的体内杀伤检测方法, 该方法能够检查细胞毒性 T 淋巴细胞 (CTL) 对模型肿瘤抗原的反应中的免疫调节。我们提供了如何将这种优雅的检测方法用于机械研究和药物疗效测试的示例。

Tags

免疫学与感染 第147期 CD8+ t 细胞 细胞毒性 癌症 免疫调节 肿瘤衍生肽 大型 t 抗原 调节 t 细胞 pd-1 检查点抑制剂 药物疗效检测 流式细胞仪
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