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Journal / Immunology and Infection / Tümör-spesifik CD8+ T hücre tepkiler…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Tümör-spesifik CD8+ T hücre tepkiler Immunodominance çalışması Için In vivo sitotoksisite assays terzilik
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Tümör-spesifik CD8+ T hücre tepkiler Immunodominance çalışması Için In vivo sitotoksisite assays terzilik

Article DOI: 10.3791/59531-v • 10:13 min • May 6th, 2019
May 6th, 2019 •
1, 1, 1,2,3,4
1Department of Microbiology and Immunology, Western University, 2Department of Medicine, Division of Clinical Immunology and Allergy, Western University, 3Department of Surgery, Division of General Surgery, Western University, 4Lawson Health Research Institute

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Burada, sitotoksisik T lenfosit (CTL) yanıt olarak bir model tümör antijeni için immundominance muayene sağlayan bir akış sitometri tabanlı in vivo öldürme tahlil tarif. Biz bu zarif tahlil mekanik çalışmalar için ve ilaç etkinliği test için istihdam olabilir nasıl örnekler sunuyoruz.

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İmmünoloji ve enfeksiyon sayı 147 CD8+ T hücreler sitotoksisite kanser immundominance tümör türevi peptidler büyük t antijen düzenleyici T HÜCRELERI PD-1 kontrol noktası inhibitörleri ilaç etkinliği testi akış sitometri
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