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同源原位骨肉瘤Sprague Dawley大鼠模型,截肢控制转移率
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Krebsforschung
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JoVE Journal
Krebsforschung
A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Please note that all translations are automatically generated.
Click here for the English version.
同源原位骨肉瘤Sprague Dawley大鼠模型,截肢控制转移率
DOI:
10.3791/62139-v
•
07:31 min
•
May 03, 2021
•
Shun Ishiyama
2,3,4
,
Casey Kissel
,
Xin Guo
,
Alexis Howard
,
Harumi Saeki
,
Tomoaki Ito
,
Polina Sysa-Shah
,
Hajime Orita
,
Kazuhiro Sakamoto
,
Kathleen Gabrielson
2
1
Department of Molecular and Comparative Pathobiology
,
The Johns Hopkins University School of Medicine
,
2
Sidney Kimmel Comprehensive Cancer Center
,
Johns Hopkins University
,
3
Department of Surgery
,
Johns Hopkins University School of Medicine
,
4
Department of Coloproctological Surgery
,
Juntendo University Faculty of Medicine
,
5
Program for Comparative Medicine, Gene Therapy Program, Perelman School of Medicine
,
University of Pennsylvania
,
6
Tuskegee College of Veterinary Medicine
,
7
Department of Human Pathology
,
Juntendo University Faculty of Medicine
,
8
Department of Surgery, Juntendo University Shizuoka Hospital
,
Juntendo University School of Medicine
,
9
Department of Urology
,
The Johns Hopkins School of Medicine
,
10
Department of Gastroenterology and Minimally Invasive Surgery
,
Juntendo University Faculty of Medicine
Kapitel
00:04
Introduction
01:19
Intratibial Osteosarcoma (OS) Cell Injection
02:41
Doxorubicin Intravenous Administration
03:36
Hind Limb Amputation
05:08
Results: Representative Rat OS Imaging and Analysis
06:43
Conclusion
Summary
Automatische Übersetzung
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Automatische Übersetzung
在这里,描述了同源原位植入术,然后是伴有自发性肺转移的骨肉瘤的截肢手术,可用于转移生物学的临床前研究和新疗法的开发。
Tags
Syngeneic Orthotopic Osteosarcoma
Sprague Dawley Rat Model
Amputation
Lung Metastasis
Jugular Vein Injection
Nanoparticle Delivery
Radiolabeled Ligand
Limb Amputation
Tibia Injection
Tumor Cell Implantation
Doxorubicin Administration
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