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En kanin aortaklaffstenose modell indusert av direkte ballong skade

Article DOI: 10.3791/65078-v • 07:10 min • March 31st, 2023
March 31st, 2023 •
*1, *1, 1, 1, 1, 1, 1,2, 3, 1,4
1Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, 2Division of Cardiology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 3College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, 4Division of Cardiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
* These authors contributed equally

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En egnet dyremodell er nødvendig for å forstå de patologiske mekanismene som ligger til grunn for aortaklaffstenose (AVS) og for å evaluere effekten av terapeutiske intervensjoner. Denne protokollen beskriver en ny prosedyre for utvikling av AVS-kaninmodellen via en direkte ballongskade in vivo.

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Kanin aortaklaffstenose modell direkte ballongskade dyremodeller patologiske mekanismer AVS kaninmodeller store dyreforsøk kosttilskudd genetisk manipulasjon eksperimentelle studier protokoll New Zealand hvite kaniner kirurgisk prosedyre postoperativ behandling initiering og progresjon av AVS patologiske mekanismer
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