Catherine Verfaillie Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL) KU Leuven Biography Publications Institution JoVE Articles Catherine Verfaillie has not added a biography. If you are Catherine Verfaillie and would like to personalize this page please email our Author Liaison for assistance. Publications Engineering Neurovascular Organoids with 3D Printed Microfluidic Chips Lab on a Chip. 04, 2022 | Pubmed ID: 35333271 Metabolically Improved Stem Cell Derived Hepatocyte-Like Cells Support HBV Life Cycle and Are a Promising Tool for HBV Studies and Antiviral Drug Screenings Biomedicines. Jan, 2022 | Pubmed ID: 35203482 An in Vitro Strategy Using Multiple Human Induced Pluripotent Stem Cell-derived Models to Assess the Toxicity of Chemicals: A Case Study on Paraquat Toxicology in Vitro : an International Journal Published in Association with BIBRA. Jun, 2022 | Pubmed ID: 35182771 Current Status and Challenges of Human Induced Pluripotent Stem Cell-Derived Liver Models in Drug Discovery Cells. 01, 2022 | Pubmed ID: 35159250 Human IPSC Model Reveals a Central Role for NOX4 and Oxidative Stress in Duchenne Cardiomyopathy Stem Cell Reports. 02, 2022 | Pubmed ID: 35090586 A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of IPSC Differentiation to Hepatocytes Journal of Proteome Research. 03, 2022 | Pubmed ID: 34982937 Organoid and Microfluidics-based Platforms for Drug Screening in COVID-19 Drug Discovery Today. 04, 2022 | Pubmed ID: 34954328 HiPSC-Derived Hepatocyte-like Cells Can Be Used As a Model for Transcriptomics-Based Study of Chemical Toxicity Toxics. Dec, 2021 | Pubmed ID: 35051043 Fluorescent Tagging of Endogenous Heme Oxygenase-1 in Human Induced Pluripotent Stem Cells for High Content Imaging of Oxidative Stress in Various Differentiated Lineages Archives of Toxicology. 10, 2021 | Pubmed ID: 34480604 Fetal Hematopoietic Stem Cell Homing is Controlled by VEGF Regulating the Integrity and Oxidative Status of the Stromal-vascular Bone Marrow Niches Cell Reports. 08, 2021 | Pubmed ID: 34433017 Fast and Efficient Generation of Isogenic Induced Pluripotent Stem Cell Lines Using Adenine Base Editing The CRISPR Journal. 08, 2021 | Pubmed ID: 34406036 Doxycycline Inducible Overexpression Systems: How to Induce Your Gene of Interest Without Inducing Misinterpretations Molecular Biology of the Cell. 08, 2021 | Pubmed ID: 34383558 Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities Frontiers in Molecular Neuroscience. 2021 | Pubmed ID: 34366786 MMP2 Modulates Inflammatory Response During Axonal Regeneration in the Murine Visual System Cells. 07, 2021 | Pubmed ID: 34359839 A Fully Defined Matrix to Support a Pluripotent Stem Cell Derived Multi-cell-liver Steatohepatitis and Fibrosis Model Biomaterials. 09, 2021 | Pubmed ID: 34304139 Actuation Enhances Patterning in Human Neural Tube Organoids Nature Communications. 05, 2021 | Pubmed ID: 34045434 SOX9-induced Generation of Functional Astrocytes Supporting Neuronal Maturation in an All-human System Stem Cell Reviews and Reports. 10, 2021 | Pubmed ID: 33982246 Directed Differentiation of Human Induced Pluripotent Stem Cells to Hepatic Stellate Cells Nature Protocols. 05, 2021 | Pubmed ID: 33864055 Rectal Organoid Morphology Analysis (ROMA) As a Promising Diagnostic Tool in Cystic Fibrosis Thorax. 11, 2021 | Pubmed ID: 33859053 -derived Arginine-containing Dipeptide Repeats Associate with Axonal Transport Machinery and Impede Microtubule-based Motility Science Advances. Apr, 2021 | Pubmed ID: 33837088 HDAC6 Inhibition Restores TDP-43 Pathology and Axonal Transport Defects in Human Motor Neurons with TARDBP Mutations The EMBO Journal. Apr, 2021 | Pubmed ID: 33694180 Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen Journal of Immunology (Baltimore, Md. : 1950). 04, 2021 | Pubmed ID: 33637617 Systematic Transcriptome-based Comparison of Cellular Adaptive Stress Response Activation Networks in Hepatic Stem Cell-derived Progeny and Primary Human Hepatocytes Toxicology in Vitro : an International Journal Published in Association with BIBRA. Jun, 2021 | Pubmed ID: 33545341 PU.1 Drives Specification of Pluripotent Stem Cell-derived Endothelial Cells to LSEC-like Cells Cell Death & Disease. 01, 2021 | Pubmed ID: 33446637 Comparing in Vitro Human Liver Models to in Vivo Human Liver Using RNA-Seq Archives of Toxicology. 02, 2021 | Pubmed ID: 33106934 Correction of CFTR Function in Intestinal Organoids to Guide Treatment of Cystic Fibrosis The European Respiratory Journal. 01, 2021 | Pubmed ID: 32747394 Gene Editing Technology for Improving Life Quality: A Dream Coming True? Clinical Genetics. 01, 2021 | Pubmed ID: 32506418 Therapeutic Modalities and Novel Approaches in Regenerative Medicine for COVID-19 International Journal of Antimicrobial Agents. Dec, 2020 | Pubmed ID: 33213829 Generation of Oligodendrocytes and Establishment of an All-human Myelinating Platform from Human Pluripotent Stem Cells Nature Protocols. 11, 2020 | Pubmed ID: 33097924 Towards Mimicking the Fetal Liver Niche: The Influence of Elasticity and Oxygen Tension on Hematopoietic Stem/Progenitor Cells Cultured in 3D Fibrin Hydrogels International Journal of Molecular Sciences. Sep, 2020 | Pubmed ID: 32887387 The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver Stem Cell Reports. 08, 2020 | Pubmed ID: 32735820 The EU-ToxRisk Method Documentation, Data Processing and Chemical Testing Pipeline for the Regulatory Use of New Approach Methods Archives of Toxicology. 07, 2020 | Pubmed ID: 32632539 Ex Vivo Mimicking of Inflammation in Organoids Derived From Patients With Ulcerative Colitis Gastroenterology. 10, 2020 | Pubmed ID: 32474118 Corrigendum to "FANCA Knockout in Human Embryonic Stem Cells Causes a Severe Growth Disadvantage" [Stem Cell Res.13/2 (2014) 240-50] Stem Cell Research. 04, 2020 | Pubmed ID: 32199280 Amino Acid Levels Determine Metabolism and CYP450 Function of Hepatocytes and Hepatoma Cell Lines Nature Communications. 03, 2020 | Pubmed ID: 32170132 Alternative Cell Sources for Liver Parenchyma Repopulation: Where Do We Stand? Cells. 02, 2020 | Pubmed ID: 32121068 Unraveling the Transcriptional Determinants of Liver Sinusoidal Endothelial Cell Specialization American Journal of Physiology. Gastrointestinal and Liver Physiology. 04, 2020 | Pubmed ID: 32116021 Functional Expression and Pharmacological Modulation of TRPM3 in Human Sensory Neurons British Journal of Pharmacology. Jun, 2020 | Pubmed ID: 31985045 Inflammation-associated Suppression of Metabolic Gene Networks in Acute and Chronic Liver Disease Archives of Toxicology. Jan, 2020 | Pubmed ID: 31919559 Integrative and Perturbation-based Analysis of the Transcriptional Dynamics of TGFβ/BMP System Components in Transition from Embryonic Stem Cells to Neural Progenitors Stem Cells (Dayton, Ohio). 02, 2020 | Pubmed ID: 31675135 Carfilzomib-induced Reticulocytosis in Patients with Multiple Myeloma is Caused by Impaired Terminal Erythroid Maturation Leukemia. 02, 2020 | Pubmed ID: 31467428 Stem-cell-derived Human Microglia Transplanted in Mouse Brain to Study Human Disease Nature Neuroscience. 12, 2019 | Pubmed ID: 31659342 Dystrophin Deficiency Leads to Dysfunctional Glutamate Clearance in IPSC Derived Astrocytes Translational Psychiatry. 08, 2019 | Pubmed ID: 31434868 Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA Cell Reports. 03, 2019 | Pubmed ID: 30917309 Breast Cancer Cells Rely on Environmental Pyruvate to Shape the Metastatic Niche Nature. 04, 2019 | Pubmed ID: 30814728 Evidence for an Alternative Fatty Acid Desaturation Pathway Increasing Cancer Plasticity Nature. 02, 2019 | Pubmed ID: 30728499 The Impact of Integrin β2 on Granulocyte/Macrophage Progenitor Proliferation Stem Cells (Dayton, Ohio). 03, 2019 | Pubmed ID: 30537419 Human Stem Cell-derived Monocytes and Microglia-like Cells Reveal Impaired Amyloid Plaque Clearance Upon Heterozygous or Homozygous Loss of TREM2 Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 03, 2019 | Pubmed ID: 30442540 Human Stem Cell-derived Hepatocyte-like Cells Support Zika Virus Replication and Provide a Relevant Model to Assess the Efficacy of Potential Antivirals PloS One. 2018 | Pubmed ID: 30566505 Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis Cell Stem Cell. Jul, 2018 | Pubmed ID: 30049452 Generation of a Human Induced Pluripotent Stem Cell-based Model for Tauopathies Combining Three Microtubule-associated Protein TAU Mutations Which Displays Several Phenotypes Linked to Neurodegeneration Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10, 2018 | Pubmed ID: 30036493 Energy Producing Metabolic Pathways in Functional Regulation of the Hematopoietic Stem Cells IUBMB Life. 07, 2018 | Pubmed ID: 29999238 In Vitro Pluripotent Stem Cell Differentiation to Hepatocyte Ceases Further Maturation at an Equivalent Stage of E15 in Mouse Embryonic Liver Development Stem Cells and Development. 07, 2018 | Pubmed ID: 29851366 The Human Somatostatin Receptor Type 2 As an Imaging and Suicide Reporter Gene for Pluripotent Stem Cell-derived Therapy of Myocardial Infarction Theranostics. 2018 | Pubmed ID: 29774076 Generation of Hepatocyte- and Endocrine Pancreatic-like Cells from Human Induced Endodermal Progenitor Cells PloS One. 2018 | Pubmed ID: 29750821 Strategies for In Vivo Genome Editing in Nondividing Cells Trends in Biotechnology. 08, 2018 | Pubmed ID: 29685818 Recent Advances in Lineage Differentiation from Stem Cells: Hurdles and Opportunities? F1000Research. 2018 | Pubmed ID: 29552337 Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels During Wound Healing and Lymphedema Scientific Reports. 03, 2018 | Pubmed ID: 29497054 PFN2 and GAMT As Common Molecular Determinants of Axonal Charcot-Marie-Tooth Disease Journal of Neurology, Neurosurgery, and Psychiatry. 08, 2018 | Pubmed ID: 29449460 Folic Acid Exposure Rescues Spina Bifida Aperta Phenotypes in Human Induced Pluripotent Stem Cell Model Scientific Reports. 02, 2018 | Pubmed ID: 29440666 Generating Tissue-resident Macrophages from Pluripotent Stem Cells: Lessons Learned from Microglia Cellular Immunology. 08, 2018 | Pubmed ID: 29433896 SOX10 Single Transcription Factor-Based Fast and Efficient Generation Of Oligodendrocytes from Human Pluripotent Stem Cells Stem Cell Reports. 02, 2018 | Pubmed ID: 29337119 Human Intestinal Epithelium in a Dish: Current Models for Research into Gastrointestinal Pathophysiology United European Gastroenterology Journal. Dec, 2017 | Pubmed ID: 29238585 Dynamic Regulation of EZH2 from HPSc to Hepatocyte-like Cell Fate PloS One. 2017 | Pubmed ID: 29091973 HDAC6 Inhibition Reverses Axonal Transport Defects in Motor Neurons Derived from FUS-ALS Patients Nature Communications. 10, 2017 | Pubmed ID: 29021520 Replication of the Zika Virus in Different IPSC-derived Neuronal Cells and Implications to Assess Efficacy of Antivirals Antiviral Research. Sep, 2017 | Pubmed ID: 28736077 Immunoregulatory Effects of Multipotent Adult Progenitor Cells in a Porcine Ex Vivo Lung Perfusion Model Stem Cell Research & Therapy. Jul, 2017 | Pubmed ID: 28676074 Molecular Imaging of Human Embryonic Stem Cells Stably Expressing Human PET Reporter Genes After Zinc Finger Nuclease-Mediated Genome Editing Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 10, 2017 | Pubmed ID: 28596158 Multipotent Adult Progenitor Cells Improve the Hematopoietic Function in Myelodysplasia Cytotherapy. 06, 2017 | Pubmed ID: 28499585 Proline Metabolism Supports Metastasis Formation and Could Be Inhibited to Selectively Target Metastasizing Cancer Cells Nature Communications. 05, 2017 | Pubmed ID: 28492237 Hmga2 Translocation Induced in Skin Tumorigenesis Oncotarget. May, 2017 | Pubmed ID: 28415789 Activin A Modulates CRIPTO-1/HNF4 Cells to Guide Cardiac Differentiation from Human Embryonic Stem Cells Stem Cells International. 2017 | Pubmed ID: 28163723 Epithelial Organoid Cultures from Patients with Ulcerative Colitis and Crohn's Disease: a Truly Long-term Model to Study the Molecular Basis for Inflammatory Bowel Disease? Gut. 12, 2017 | Pubmed ID: 28159838 PDGFRα Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors Stem Cell Reports. 02, 2017 | Pubmed ID: 28089671 Distinct Molecular Signature of Murine Fetal Liver and Adult Hematopoietic Stem Cells Identify Novel Regulators of Hematopoietic Stem Cell Function Stem Cells and Development. 04, 2017 | Pubmed ID: 27958775 Dual Loss of Succinate Dehydrogenase (SDH) and Complex I Activity is Necessary to Recapitulate the Metabolic Phenotype of SDH Mutant Tumors Metabolic Engineering. 09, 2017 | Pubmed ID: 27847310 Cell Expansion During Directed Differentiation of Stem Cells Toward the Hepatic Lineage Stem Cells and Development. 02, 2017 | Pubmed ID: 27806669 Outside-in Integrin Signalling Regulates Haematopoietic Stem Cell Function Via Periostin-Itgav Axis Nature Communications. 12, 2016 | Pubmed ID: 27905395 De Novo Design of a Biologically Active Amyloid Science (New York, N.Y.). 11, 2016 | Pubmed ID: 27846578 H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in HESC-Derived Hepatocytes In Vitro Stem Cell Reports. Aug, 2016 | Pubmed ID: 27477635 Clinical-Grade Human Multipotent Adult Progenitor Cells Block CD8+ Cytotoxic T Lymphocytes Stem Cells Translational Medicine. Jul, 2016 | Pubmed ID: 27465071 Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts Stem Cells International. 2016 | Pubmed ID: 27403168 Pancreatic Differentiation of Pdx1-GFP Reporter Mouse Induced Pluripotent Stem Cells Differentiation; Research in Biological Diversity. 12, 2016 | Pubmed ID: 27181524 Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved Journal of the American Heart Association. Apr, 2016 | Pubmed ID: 27091182 Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging Stem Cells International. 2016 | Pubmed ID: 26997958 In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants Stem Cells (Dayton, Ohio). 07, 2016 | Pubmed ID: 26992046 Monitoring the Bystander Killing Effect of Human Multipotent Stem Cells for Treatment of Malignant Brain Tumors Stem Cells International. 2016 | Pubmed ID: 26880961 Stem Cell-derived Hepatocytes: A Novel Model for Hepatitis E Virus Replication Journal of Hepatology. Mar, 2016 | Pubmed ID: 26626494 Altered Neuronal Network and Rescue in a Human MECP2 Duplication Model Molecular Psychiatry. Feb, 2016 | Pubmed ID: 26347316 Sodium Iodide Symporter PET and BLI Noninvasively Reveal Mesoangioblast Survival in Dystrophic Mice Stem Cell Reports. Dec, 2015 | Pubmed ID: 26626179 Highly Proliferative Primitive Fetal Liver Hematopoietic Stem Cells Are Fueled by Oxidative Metabolic Pathways Stem Cell Research. Nov, 2015 | Pubmed ID: 26599326 Mesodermal IPSC-derived Progenitor Cells Functionally Regenerate Cardiac and Skeletal Muscle The Journal of Clinical Investigation. Dec, 2015 | Pubmed ID: 26571398 Efficient Recombinase-Mediated Cassette Exchange in HPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition Stem Cell Reports. Nov, 2015 | Pubmed ID: 26455413 Assessment of Bystander Killing-mediated Therapy of Malignant Brain Tumors Using a Multimodal Imaging Approach Stem Cell Research & Therapy. Sep, 2015 | Pubmed ID: 26345383 Contribution of Different Bone Marrow-derived Cell Types in Endometrial Regeneration Using an Irradiated Murine Model Fertility and Sterility. Jun, 2015 | Pubmed ID: 25813284 Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Stem Cell Reports. Jan, 2015 | Pubmed ID: 25556567 Radiolabeling Strategies for Radionuclide Imaging of Stem Cells Stem Cell Reviews. Apr, 2015 | Pubmed ID: 25534590 Controlling and Monitoring Stem Cell Safety in Vivo in an Experimental Rodent Model Stem Cells (Dayton, Ohio). Nov, 2014 | Pubmed ID: 25142614 FANCA Knockout in Human Embryonic Stem Cells Causes a Severe Growth Disadvantage Stem Cell Research. Sep, 2014 | Pubmed ID: 25108529 SMAD Signaling Regulates CXCL12 Expression in the Bone Marrow Niche, Affecting Homing and Mobilization of Hematopoietic Progenitors Stem Cells (Dayton, Ohio). Nov, 2014 | Pubmed ID: 25069965 Optimization of Multimodal Imaging of Mesenchymal Stem Cells Using the Human Sodium Iodide Symporter for PET and Cerenkov Luminescence Imaging PloS One. 2014 | Pubmed ID: 24747914 MicroRNAs: the Fine Modulators of Liver Development and Function Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2014 | Pubmed ID: 24517588 Prospectively Isolated NGN3-expressing Progenitors from Human Embryonic Stem Cells Give Rise to Pancreatic Endocrine Cells Stem Cells Translational Medicine. Apr, 2014 | Pubmed ID: 24493854 Hepatic Differentiation of Human Embryonic Stem Cells on Microcarriers Journal of Biotechnology. Mar, 2014 | Pubmed ID: 24480567 Biliary Cells to the Rescue of Prometheus Gastroenterology. Mar, 2014 | Pubmed ID: 24462990 Mutual Interaction Between Human Multipotent Adult Progenitor Cells and NK Cells Cell Transplantation. 2014 | Pubmed ID: 23562064 Mesenchymal Stem Cells Migration Homing and Tracking Stem Cells International. 2013 | Pubmed ID: 24194766 Self-renewal of Neural Stem Cells: Implications for Future Therapies Frontiers in Physiology. 2013 | Pubmed ID: 23513073 18F-FDG Labeling of Mesenchymal Stem Cells and Multipotent Adult Progenitor Cells for PET Imaging: Effects on Ultrastructure and Differentiation Capacity Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Mar, 2013 | Pubmed ID: 23353687 COUP-TFII Orchestrates Venous and Lymphatic Endothelial Identity by Homo- or Hetero-dimerisation with PROX1 Journal of Cell Science. Mar, 2013 | Pubmed ID: 23345397 Glypican-3-mediated Inhibition of CD26 by TFPI: a Novel Mechanism in Hematopoietic Stem Cell Homing and Maintenance Blood. Apr, 2013 | Pubmed ID: 23327927 Immunological Characteristics of Human Mesenchymal Stem Cells and Multipotent Adult Progenitor Cells Immunology and Cell Biology. Jan, 2013 | Pubmed ID: 23295415 A Novel Role of BMP4 in Adult Hematopoietic Stem and Progenitor Cell Homing Via Smad Independent Regulation of Integrin-α4 Expression Blood. Jan, 2013 | Pubmed ID: 23243277 Neural Differentiation and Support of Neuroregeneration of Non-neural Adult Stem Cells Progress in Brain Research. 2012 | Pubmed ID: 23186708 Antagonism of Nodal Signaling by BMP/Smad5 Prevents Ectopic Primitive Streak Formation in the Mouse Amnion Development (Cambridge, England). Sep, 2012 | Pubmed ID: 22912414 Human Pluripotent Stem Cell-derived Hepatocytes Support Complete Replication of Hepatitis C Virus Journal of Hepatology. Aug, 2012 | Pubmed ID: 22521345 Differentiation but Not ALS Mutations in FUS Rewires Motor Neuron Metabolism Nature Communications. | Pubmed ID: 31515480 Analyse de la morphologie organoïde rectale (ROMA): un test diagnostique dans la fibrose kystique Senne Cuyx1,2, Anabela S. Ramalho1, Nikky Corthout3,4, Steffen Fieuws5, Eva Fürstová6, Kaline Arnauts7,8, Marc Ferrante7,9, Catherine Verfaillie8, Sebastian Munck3,4, Mieke Boon1,2, Marijke Proesmans1,2, Lieven Dupont10,11, Kris De Boeck1,2, François Vermeulen1,2 1Department of Development and Regeneration, Woman and Child Unit, CF research lab, KU Leuven, 2Department of Pediatrics, Pediatric Pulmonology, University Hospitals Leuven, 3VIB Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, 4Department for Neuroscience, KU Leuven, 5Interuniversity Center for Biostatistics and Statistical Bioinformatics, University of Leuven and University of Hasselt, 6Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, 7Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 8Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, 9Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, 10Department of Chronic Diseases, Metabolism and Ageing; Pneumology, KU Leuven, 11Department of Respiratory Diseases, University Hospitals Leuven JoVE 63818 Medicina
Analyse de la morphologie organoïde rectale (ROMA): un test diagnostique dans la fibrose kystique Senne Cuyx1,2, Anabela S. Ramalho1, Nikky Corthout3,4, Steffen Fieuws5, Eva Fürstová6, Kaline Arnauts7,8, Marc Ferrante7,9, Catherine Verfaillie8, Sebastian Munck3,4, Mieke Boon1,2, Marijke Proesmans1,2, Lieven Dupont10,11, Kris De Boeck1,2, François Vermeulen1,2 1Department of Development and Regeneration, Woman and Child Unit, CF research lab, KU Leuven, 2Department of Pediatrics, Pediatric Pulmonology, University Hospitals Leuven, 3VIB Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, 4Department for Neuroscience, KU Leuven, 5Interuniversity Center for Biostatistics and Statistical Bioinformatics, University of Leuven and University of Hasselt, 6Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, 7Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 8Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, 9Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, 10Department of Chronic Diseases, Metabolism and Ageing; Pneumology, KU Leuven, 11Department of Respiratory Diseases, University Hospitals Leuven JoVE 63818 Medicina