Chrisostomos Prodromou School of Life Sciences University of Sussex Biography Publications Institution JoVE Articles Chrisostomos Prodromou has not added a biography. If you are Chrisostomos Prodromou and would like to personalize this page please email our Author Liaison for assistance. Publications HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease Sub-cellular Biochemistry. 2023 | Pubmed ID: 36520314 Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant Biomolecules. Jun, 2022 | Pubmed ID: 35883461 Advances Towards Understanding the Mechanism of Action of the Hsp90 Complex Biomolecules. Apr, 2022 | Pubmed ID: 35625528 Two-colour Single-molecule Photoinduced Electron Transfer Fluorescence Imaging Microscopy of Chaperone Dynamics Nature Communications. Nov, 2021 | Pubmed ID: 34845214 Structure of the TELO2-TTI1-TTI2 Complex and Its Function in TOR Recruitment to the R2TP Chaperone Cell Reports. Jul, 2021 | Pubmed ID: 34233195 The Structure-function Relationship of Oncogenic LMTK3 Science Advances. Nov, 2020 | Pubmed ID: 33188023 Clinical and Functional Analyses of AIPL1 Variants Reveal Mechanisms of Pathogenicity Linked to Different Forms of Retinal Degeneration Scientific Reports. Oct, 2020 | Pubmed ID: 33067476 Editorial: The Role of Heat Shock Proteins in Neuroprotection Frontiers in Pharmacology. 2020 | Pubmed ID: 32848805 Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90-Client Interactions Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2020 | Pubmed ID: 32167602 Structural Mechanism for Regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP Co-chaperone Revealed by Cryo-EM Science Advances. May, 2019 | Pubmed ID: 31049401 Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90 Cell Reports. Jan, 2019 | Pubmed ID: 30699359 Advances on the Structure of the R2TP/Prefoldin-like Complex Advances in Experimental Medicine and Biology. 2018 | Pubmed ID: 30484153 Author Correction: RPAP3 Provides a Flexible Scaffold for Coupling HSP90 to the Human R2TP Co-chaperone Complex Nature Communications. Jul, 2018 | Pubmed ID: 30065299 Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection Frontiers in Molecular Biosciences. 2018 | Pubmed ID: 29930942 RPAP3 Provides a Flexible Scaffold for Coupling HSP90 to the Human R2TP Co-chaperone Complex Nature Communications. Apr, 2018 | Pubmed ID: 29662061 Bioassay to Test the Pathogenicity of Missense Human Variants Journal of Medical Genetics. Aug, 2018 | Pubmed ID: 29632148 Multi-chaperone Function Modulation and Association with Cytoskeletal Proteins Are Key Features of the Function of AIP in the Pituitary Gland Oncotarget. Feb, 2018 | Pubmed ID: 29507682 The Integrity and Organization of the Human AIPL1 Functional Domains is Critical for Its Role As a HSP90-dependent Co-chaperone for Rod PDE6 Human Molecular Genetics. Apr, 2018 | Pubmed ID: 29351602 The Stoichiometric Interaction of the Hsp90-Sgt1-Rar1 Complex by CD and SRCD Spectroscopy Frontiers in Molecular Biosciences. 2017 | Pubmed ID: 29387685 Tumor Suppressor Tsc1 is a New Hsp90 Co-chaperone That Facilitates Folding of Kinase and Non-kinase Clients The EMBO Journal. 12, 2017 | Pubmed ID: 29127155 Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System Cell Reports. Oct, 2017 | Pubmed ID: 29091774 The Integrity and Organization of the Human AIPL1 Functional Domains is Critical for Its Role As a HSP90-dependent Co-chaperone for Rod PDE6 Human Molecular Genetics. Nov, 2017 | Pubmed ID: 28973376 The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System Structure (London, England : 1993). Jul, 2017 | Pubmed ID: 28648606 HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients Cell Reports. Jun, 2017 | Pubmed ID: 28636940 The Structure of FKBP38 in Complex with the MEEVD Tetratricopeptide Binding-motif of Hsp90 PloS One. 2017 | Pubmed ID: 28278223 Mechanisms of Hsp90 Regulation The Biochemical Journal. Aug, 2016 | Pubmed ID: 27515256 The FNIP Co-chaperones Decelerate the Hsp90 Chaperone Cycle and Enhance Drug Binding Nature Communications. 06, 2016 | Pubmed ID: 27353360 Cooperation of Local Motions in the Hsp90 Molecular Chaperone ATPase Mechanism Nature Chemical Biology. Aug, 2016 | Pubmed ID: 27322067 Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations The Journal of Clinical Endocrinology and Metabolism. Aug, 2016 | Pubmed ID: 27253664 Dihydropyridine Derivatives Modulate Heat Shock Responses and Have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. May, 2016 | Pubmed ID: 27163800 Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors Cell Reports. Feb, 2016 | Pubmed ID: 26804907 C-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells Cell Reports. Aug, 2015 | Pubmed ID: 26235616 Tah1 Helix-swap Dimerization Prevents Mixed Hsp90 Co-chaperone Complexes Acta Crystallographica. Section D, Biological Crystallography. May, 2015 | Pubmed ID: 25945584 Structural Basis for Phosphorylation-dependent Recruitment of Tel2 to Hsp90 by Pih1 Structure (London, England : 1993). Jun, 2014 | Pubmed ID: 24794838 Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-competitive Inhibitors Molecular Cell. Jan, 2014 | Pubmed ID: 24462205 Synthesis of 19-substituted Geldanamycins with Altered Conformations and Their Binding to Heat Shock Protein Hsp90 Nature Chemistry. Apr, 2013 | Pubmed ID: 23511419 ATP-competitive Inhibitors Block Protein Kinase Recruitment to the Hsp90-Cdc37 System Nature Chemical Biology. May, 2013 | Pubmed ID: 23502424 Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-terminal α-7 Helix of the TPR Domain of AIP is Sufficient for Pituitary Adenoma Predisposition PloS One. 2012 | Pubmed ID: 23300914 CDK-dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-cycle Progression Cell. Dec, 2012 | Pubmed ID: 23217712 Co-crystalization and in Vitro Biological Characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 Inhibitors PloS One. 2012 | Pubmed ID: 22984537 Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50(CDC37)-AHA1 Chaperone Machine Molecular Cell. Aug, 2012 | Pubmed ID: 22727666 Charged Linker Sequence Modulates Eukaryotic Heat Shock Protein 90 (Hsp90) Chaperone Activity Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22315411 The 'active Life' of Hsp90 Complexes Biochimica Et Biophysica Acta. Mar, 2012 | Pubmed ID: 21840346 Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity Molecular Cell. Mar, 2011 | Pubmed ID: 21419342 Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors Molecular Cell. Jul, 2010 | Pubmed ID: 20670895 孔雀石绿测定法用于发现热休克蛋白 90 抑制剂 Sayan Dutta Gupta1, Dae-Geun Song1, SueJung Lee1, Jae Wook Lee1, Jin-Soo Park1, Chrisostomos Prodromou2, Cheol-Ho Pan1 1Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), 2School of Life Sciences, University of Sussex JoVE 64693 Bioquímica
孔雀石绿测定法用于发现热休克蛋白 90 抑制剂 Sayan Dutta Gupta1, Dae-Geun Song1, SueJung Lee1, Jae Wook Lee1, Jin-Soo Park1, Chrisostomos Prodromou2, Cheol-Ho Pan1 1Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), 2School of Life Sciences, University of Sussex JoVE 64693 Bioquímica