Hollow Channel Structure
Hollow Channel Structure - Related Videos
10:22
Reconstitution of a Kv Channel into Lipid Membranes for Structural and Functional Studies
0 Views •
Cited by 11 •
2013
Procedures for complete reconstitution of a prototype voltage-gated potassium channel into lipid membranes are described. The reconstituted channels are suitable for biochemical assays, electrical recordings, ligand screening and electron crystallographic studies. These methods may have general applications to the structural and functional studies of other membrane proteins.
08:19
Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
0 Views •
Cited by 34 •
2012
This article details the construction of a multiplexed microneedle-based sensor. The device is being developed for in situ sampling and electrochemical analysis of multiple analytes in a rapid and selective manner. We envision clinical medicine and biomedical research uses for these microneedle-based sensors.
08:28
Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
0 Views •
Cited by 28 •
2016
The functional behavior of cells in culture can be improved by culturing in more in vivo-like 3-dimensional culture environments16-21. This manuscript describes the set-up and operation of a hollow fiber bioreactor system for in vivo-like mammalian tissue culture.
01:15
Thin-Walled Hollow Shafts
0 Views •
2024
In analyzing a thin-walled hollow shaft subjected to torsional loading, a segment with width dx is isolated for examination. Despite its equilibrium state, this segment faces torsional shearing forces at its ends. These forces are quantitatively described by the product of the longitudinal shearing stress on the segment's minor surface and the area of this surface, leading to the concept of shear flow. This shear flow is consistent throughout the structure, indicating a uniform distribution of...
09:27
Encapsulation and Permeability Characteristics of Plasma Polymerized Hollow Particles
0 Views •
Cited by 1 •
2012
We have used plasma enhanced chemical vapor deposition to deposit thin films ranging from a few nm to several 100 nm on nano-sized particles of various materials. We subsequently etch the core material to produce hollow nanoshells whose permeability is controlled by the thickness of the shell. We characterize the permeability of these coatings to small solutes and demonstrate that these barriers can provide sustained release of the core material over several days.
FAQs
Geometry determines the shape and dimensions of the internal pathway, while connectivity determines how separate channels link within the construct. Together, these features influence fluid movement and mass transfer through the three-dimensional system. Designing both factors appropriately helps organize transport pathways and supports more controlled perfusion in engineered materials and tissue constructs.
Continuous pathways provide routes through which fluids, nutrients, gases, or cells can move within a construct. This organization helps address the difficulty of supplying thick engineered tissues, where transport must reach regions beyond the external surface. The resulting internal access can support tissue maturation and improve the reproduction of important features of native tissue organization.
The surfaces lining the channels affect whether cells attach and how the surrounding tissue develops. Because surface properties influence cell attachment and tissue maturation, they are an important design consideration alongside channel geometry and connectivity. Controlling this interface can help engineered constructs support cellular organization while maintaining the intended internal transport architecture.
Several fabrication approaches can produce these internal pathways, including molding, sacrificial templating, bioprinting, and assembly. Each approach creates a defined channel arrangement within an engineered material or tissue construct. The resulting architecture can then be used to organize transport and three-dimensional structure for applications such as perfusable tissues, vascular-like systems, and microfluidic devices.
Researchers use hollow channels when a construct needs organized internal access for fluid, nutrient, gas, or cell transport. This is especially relevant to thick engineered tissues, where external delivery alone may not reproduce native organization. Channel-based designs can support vascular-like networks, perfusable tissue models, and regenerative scaffolds intended to encourage tissue maturation.
Bioengineering applications include vascular-like networks, perfusable tissue models, microfluidic devices, and regenerative scaffolds. These designs provide defined internal pathways while also shaping three-dimensional architecture. Their value lies in combining transport organization with structural control, allowing engineered systems to model or support aspects of native tissue organization and maturation.