Fibroblast Growth Factors
Fibroblast Growth Factors - Related Videos
05:45
Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells
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2025
In this study, we present an in vitro cell assay for identifying teratogenic chemicals. The dynamics of fibroblast growth factor (FGF)/serum response factor (SRF) signaling were measured in human induced pluripotent stem (iPS) reporter cells, and the risk of teratogenicity was evaluated by quantifying chemical disruption of this signaling pathway.
11:00
Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
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Cited by 1 •
2016
The protocol described here details the induction of a hemogenic program in mouse embryonic fibroblasts via overexpression of a minimal set of transcription factors. This technology may be translated to the human system to provide platforms for future study of hematopoiesis, hematologic disease, and hematopoietic stem cell transplant.
18:27
Preparing T Cell Growth Factor from Rat Splenocytes
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Cited by 12 •
2007
We describe the preparation of T cell growth factor used for the in vitro expansion of antigen-specific rat T lymphocyte lines.
07:32
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Cited by 3 •
2019
Herein, we present a detailed protocol for screening small peptides that bind to FGFR2 using a phage display peptide library. We further analyze the affinity of the selected peptides toward FGFR2 in vitro and its ability to suppress cell proliferation.
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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Cited by 7 •
2016
We describe a simple cell-based bioassay for detecting, quantifying and monitoring the activity of members of the vascular endothelial growth factor family of ligands. The assay uses chimeric receptors expressed in a factor-dependent cell line to provide a semi-quantitative or quantitative assessment of receptor binding and cross-linking by the ligand.
FAQs
Binding to a fibroblast growth factor receptor initiates receptor tyrosine kinase signaling. This activation passes information into downstream pathways, which then alters cell behavior rather than producing a single universal effect. Depending on the biological setting, the resulting response can include proliferation, survival, migration, or differentiation. This signaling chain links extracellular communication with coordinated tissue-level change.
The downstream effects include changes in how cells multiply, remain viable, move, and acquire specialized characteristics. These outcomes are biologically connected: cell proliferation can expand a population, migration can reposition cells, survival can preserve tissue, and differentiation can produce distinct cell states. Together, these responses allow signaling to influence development, maintenance, and repair without implying one identical response in every cell.
Abnormal activity can disrupt the balance of cellular behaviors controlled by these signals. Excessive or improperly regulated signaling may affect proliferation, survival, migration, or differentiation in ways that contribute to disease biology, including cancer. For this reason, researchers examine fibroblast growth factor pathways not only as normal regulators but also as possible contributors to disease progression and therapeutic targets.
During development, these signals help coordinate embryonic patterning, the organized arrangement of cells and tissues as an embryo forms. They also participate in blood vessel formation, linking cellular signaling with the establishment of vascular structures. These roles show that fibroblast growth factor activity operates at a tissue scale, where coordinated cellular responses shape developing biological systems.
Tissue maintenance and wound repair require cells to respond in coordinated ways rather than act independently. Fibroblast growth factor signaling can influence the proliferation, survival, migration, and differentiation needed for those processes. Studying these signals therefore helps researchers investigate how tissues are preserved, how damaged areas are repaired, and how regeneration-related responses may be supported.
Researchers study these proteins and their receptor-driven pathways to connect molecular signaling with development, tissue regeneration, disease progression, and repair. The same framework supports investigation of abnormal activity in cancer and other disorders. Findings from this work can also inform potential therapeutic strategies by identifying how altering fibroblast growth factor signaling might affect disease or tissue responses.