Urogenital Microbiota
Urogenital Microbiota - Related Videos
01:28
Microbiota of the Urogenital Tract
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2026
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
10:24
A High Throughput in situ Hybridization Method to Characterize mRNA Expression Patterns in the Fetal Mouse Lower Urogenital Tract
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Cited by 49 •
2011
Here, we describe an efficient high throughput in situ hybridization (ISH) method for visualizing patterns of mRNA expression in developing fetal mouse prostate tissue sections. The method can be easily adapted to visualize mRNA expression patterns in other mouse tissues or in tissues from other species.
08:44
Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells
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Cited by 10 •
2013
To unravel the earliest molecular mechanisms underlying prostate cancer initiation, novel and innovative human model systems and approaches are desperately needed. The potential of pre-prostatic urogenital sinus mesenchyme (UGSM) to induce pluripotent stem cell populations to form human prostate epithelium is a powerful experimental tool in prostate research.
03:24
Extracting Prostate from Mouse Urogenital System: A Technique to Separate Prostate Gland from Other Urinary and Genital System Organs in Male Mouse
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2023
In this video, we describe the procedure for the dissection of the urogenital system or UGS from a male mouse model. This UGS is further dissected ex vivo to isolate the prostate gland and study its role in prostate cancer development.
01:15
Assessing the Role of Gut Microbiota in Modulating Hepatitis B Infection in Mice
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2026
Take a control mouse with a normal gut microbiota and an experimental mouse with depleted gut microbiota. The depletion compromises the integrity of the gut barrier.This enables bacteria to translocate through the blood vessel into the liver tissue.Inject both mice with the hepatitis B virus or HBV plasmid to induce an HBV infection in the liver tissue.In the control mouse, the T cell detects an infected liver cell through the interaction of its receptors with viral antigens, and produces...
FAQs
In some reproductive-tract sites, estrogen-associated glycogen can support lactic acid production by Lactobacillus species. This links host physiology with microbial metabolism and local environmental conditions, including pH. Because acidity is one factor that shapes microbial growth and tissue conditions, changes in this relationship may influence how communities are maintained and how susceptibility to infection is investigated.
Microorganisms interact through colonization, competition for nutrients, and production of metabolites that alter their surroundings. They also interact with host cells, creating a dynamic relationship between microbial communities and tissues. These processes help explain why community composition cannot be considered separately from local conditions, and why microbial balance may be relevant when studying tissue health or infection susceptibility.
Local pH helps determine which microorganisms can persist and how they interact with neighboring species and host tissues. In some sites, Lactobacillus-associated lactic acid production contributes to this chemical environment, with estrogen-associated glycogen providing relevant support. Measuring or interpreting community patterns alongside pH can therefore clarify how local conditions relate to microbial stability and infection susceptibility.
Profiling can characterize microbial communities associated with healthy tissues and support investigations of urinary tract infections, bacterial vaginosis, infertility, and sexually transmitted infections. Its value lies in comparing community patterns with biological conditions rather than treating a single microorganism as the complete explanation. Such comparisons can help identify relationships between microbial composition, tissue health, and disease-associated states.
Research on urogenital communities may support improved diagnostics by identifying microbial patterns associated with health or particular conditions. It may also inform targeted probiotics designed to influence community composition or local microbial activity, as well as broader microbiome-based therapies. These applications remain connected to understanding colonization, metabolite production, nutrient competition, and environmental factors such as pH.
Biologically, the topic examines interactions among microorganisms, host cells, nutrients, metabolites, and local chemical conditions. Medically, those interactions provide context for studying infections, bacterial vaginosis, infertility, and sexually transmitted infections. This connection allows researchers to use community profiling not only to describe microbial ecosystems, but also to investigate how they relate to tissue health and clinical conditions.