Clinical Biosensing Applications
Clinical Biosensing Applications - Related Videos
11:25
Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
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Cited by 4 •
2016
We describe key steps for biosensing by using polysilicon nanowire field-effect transistors, including the preparation of the device and the immobilization and confirmation of a DNA molecular probe on the nanowire surface, as well as conditions for DNA sensing.
09:39
Optical Biosensing
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2023
Optical biosensors utilize light to detect the binding of a target molecule. These sensors can utilize a label molecule, which produces a measurable signal such as fluorescence, or these sensors can be label-free and use the changes in optical properties, such as refractive index, to sense for the binding of the target molecule. This video introduces both label and label-free optical biosensors, demonstrates their use in the laboratory, and shows some applications of the technology.
07:39
Electrochemical Biosensing
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2023
Electrochemical biosensors detect the binding of a target molecule by sensing an oxidation-reduction event. These sensors paved the way for modern biosensing after the invention of the glucose biosensor. This video will introduce electrochemical biosensing, show the workings of the glucose biosensor, and discuss how electrochemical biosensors are used in cancer detection.
06:40
Overview of Biosensing
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2023
Biosensors are devices that use a wide range of biological processes and physical properties in order to detect either a biological molecule, such as a protein or cell, or a non-biological molecule, such as a chemical component or contaminant. This interdisciplinary field utilizes electrical, optical, electrochemical, or even mechanical properties to detect the presence of the target molecule. This video introduces the field of biosensing, and reviews common types of biosensor technologies.
06:58
Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
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Cited by 2 •
2010
Magnetic modulation biosensing system is utilized to rapidly, sensitively and simply detect biological assays, such as DNA molecules and proteins.
FAQs
Selectivity begins with the recognition element, which may be an antibody, enzyme, nucleic acid probe, or receptor. Each type interacts with a particular biological or chemical target through binding or catalytic activity. That interaction helps distinguish a relevant biomarker from other substances in a clinical sample, supporting measurements that can inform diagnosis, monitoring, or treatment decisions.
A transducer translates recognition or catalytic activity into a measurable signal. Clinical biosensing applications may use electrical, optical, or other signal formats, depending on how the device is designed. The resulting signal provides a basis for quantifying a biomarker rather than merely observing that an interaction occurred, making the system useful for analytical testing.
Chemical selectivity matters because biosensors may analyze blood, saliva, urine, or other biological samples containing many substances. The recognition element must respond to the relevant biomarker within that sample environment. Supporting measurements across different matrices expands clinical usefulness, while selective detection helps produce information suitable for diagnosis, physiological monitoring, and treatment-related decisions.
A typical workflow begins with introducing a biological sample to the device, allowing the target to interact with its recognition element, and recording the transducer response. That response is then used to quantify the relevant biological or chemical signal. The sequence links sample analysis to actionable information for diagnosis, monitoring, or treatment decisions.
They are particularly useful when researchers need measurements that are rapid, selective, or minimally invasive. The devices can support point-of-care diagnostics, disease surveillance, and monitoring of physiological conditions, while also contributing to personalized medicine. Their value comes from connecting biomarker measurements with timely clinical or research decisions rather than relying only on delayed analysis.
By quantifying biomarkers, clinical biosensing applications can provide measurements relevant to an individual's health state. Those data may support personalized medicine, follow changes in physiological conditions, or contribute to disease surveillance. In chemistry and biomedical research, the measurements help connect molecular or biological signals with diagnosis, ongoing monitoring, and decisions about treatment.