Dynamic Mechanical Analysis
Dynamic Mechanical Analysis - Related Videos
15:21
Microfabricated Platforms for Mechanically Dynamic Cell Culture
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Cited by 3 •
2010
In this protocol, we demonstrate the fabrication of a microactuator array of vertically displaced posts on which the technology is based, and how this base technology can be modified to conduct high-throughput mechanically dynamic cell culture in both two-dimensional and three-dimensional culture paradigms.
06:59
Environmental Dynamic Mechanical Analysis to Predict the Softening Behavior of Neural Implants
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Cited by 4 •
2019
To allow reliable predictions of the softening of polymeric substrates for neural implants in an in vivo environment, it is important to have a reliable in vitro method. Here, the use of dynamic mechanical analysis in phosphate buffered saline at body temperature is presented.
12:45
Mechanical Stimulation of Chondrocyte-agarose Hydrogels
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Cited by 29 •
2012
The biosynthesis of cartilaginous extracellular matrix by chondrocytes can be affected by application of mechanical stimuli. This method describes the technique of applying dynamic compressive strains to chondrocytes encapsulated in 3D constructs and the evaluation of induced changes in chondrocyte metabolism.
08:42
Myo-mechanical Analysis of Isolated Skeletal Muscle
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Cited by 25 •
2011
To assess the in vivo effects of therapeutic interventions for muscle disease, methods are needed to quantitate force generation and fatigability in treated muscle. We detail an approach to evaluating myo-mechanical properties in explanted mouse hindlimb muscle. This analysis provides a robust approach to quantitating the effects of genetic modification on muscle function, as well as comparison of therapies in mouse models of muscle disease.
13:43
Correlative Microscopy for 3D Structural Analysis of Dynamic Interactions
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Cited by 15 •
2013
We describe a correlative microscopy method that combines high-speed 3D live-cell fluorescent light microscopy and high-resolution cryo-electron tomography. We demonstrate the capability of the correlative method by imaging dynamic, small HIV-1 particles interacting with host HeLa cells.
FAQs
The phase difference between the applied stress and the sample’s deformation indicates how the material distributes mechanical energy. The storage modulus represents the elastic portion retained in the material, while the loss modulus represents the viscous portion dissipated during deformation. Considering both values helps distinguish changes in stiffness from changes in damping and molecular mobility.
Temperature and frequency alter the way molecular motion contributes to a material’s response. Varying temperature can reveal transitions associated with changes in molecular mobility, while changing frequency probes the response over different time scales. Examining these variables helps identify when a material becomes less stiff, more dissipative, or otherwise changes its viscoelastic behavior.
The storage modulus provides information about the material’s stiffness under the testing conditions, whereas the loss modulus indicates how much mechanical energy is dissipated. Their combined behavior can show whether a sample responds more elastically or viscously. This distinction is useful for evaluating performance when both load-bearing ability and damping influence material selection.
A sample is placed in the instrument, which applies a controlled, small oscillatory stress or strain and measures the resulting deformation. The experiment can vary temperature, frequency, or both while recording the mechanical response. Researchers then examine the resulting modulus values and phase relationship to identify stiffness changes, damping behavior, and transitions such as the glass transition.
Changes in the measured moduli and in the phase relationship can signal a glass transition, where molecular mobility changes substantially. The same data can indicate shifts in stiffness and damping across the tested conditions. These outcomes allow researchers to relate thermal or time-dependent behavior to the performance of a polymer or other material under practical operating conditions.
DMA supports polymer formulation, thermal analysis, and quality control by showing how composition and conditions affect viscoelastic performance. It is also relevant to designing coatings, adhesives, composites, and other functional materials, where stiffness, damping, and molecular mobility can influence use. Comparing responses across formulations helps guide development and assess whether a material meets its intended requirements.