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JoVE Journal
Biology

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Mechanical Stimulation of Chondrocyte-agarose Hydrogels
 

Mechanical Stimulation of Chondrocyte-agarose Hydrogels

Article DOI: 10.3791/4229
October 27th, 2012

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Summary October 27th, 2012

The biosynthesis of cartilaginous extracellular matrix by chondrocytes can be affected by application of mechanical stimuli. This method describes the technique of applying dynamic compressive strains to chondrocytes encapsulated in 3D constructs and the evaluation of induced changes in chondrocyte metabolism.

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