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Myo-mechanical Analysis of Isolated Skeletal Muscle
JoVE Journal
Medicine
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JoVE Journal Medicine
Myo-mechanical Analysis of Isolated Skeletal Muscle

Myo-mechanical Analysis of Isolated Skeletal Muscle

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08:42 min

February 22, 2011

DOI:

08:42 min
February 22, 2011

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Summary

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To assess the in vivo effects of therapeutic interventions for muscle disease, methods are needed to quantitate force generation and fatigability in treated muscle. We detail an approach to evaluating myo-mechanical properties in explanted mouse hindlimb muscle. This analysis provides a robust approach to quantitating the effects of genetic modification on muscle function, as well as comparison of therapies in mouse models of muscle disease.

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