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JoVE Journal
Medicine

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Myo-mechanical Analysis of Isolated Skeletal Muscle
 

Myo-mechanical Analysis of Isolated Skeletal Muscle

Article doi: 10.3791/2582
February 22nd, 2011

Summary February 22nd, 2011

To assess the in vivo effects of therapeutic interventions for muscle disease, methods are needed to quantitate force generation and fatigability in treated muscle. We detail an approach to evaluating myo-mechanical properties in explanted mouse hindlimb muscle. This analysis provides a robust approach to quantitating the effects of genetic modification on muscle function, as well as comparison of therapies in mouse models of muscle disease.

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