Tachypnea

Tachypnea is an abnormally rapid respiratory rate and an important clinical sign of altered ventilation, increased metabolic demand, or respiratory distress. It occurs when chemoreceptors and respiratory centers respond to signals such as low blood oxygen, elevated carbon dioxide, or metabolic acidosis, while fever, pain, anxiety, and exercise can also increase breathing frequency. Clinicians interpret tachypnea alongside age-specific reference ranges, breathing depth, oxygen saturation, and other findings because rapid breathing may accompany pneumonia, asthma, heart failure, sepsis, or metabolic disorders. Careful assessment helps identify worsening illness, guide diagnostic testing, and support timely treatment.

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JoVE Science Education - Clinical Skills

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2023

Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA The heart lies within the pericardium, a relatively inelastic fibrous sac. The pericardium has some compliance to stretch when fluid is slowly introduced into the pericardial space. However, rapid accumulation overwhelms pericardial ability to accommodate extra fluid. Once a critical volume is reached, intrapericardial pressure increases dramatically, compressing the right ventricle and...

Research

JoVE Journal - Immunology and Infection

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

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Cited by 8 •

2011

C57BL/6 mice have been used to study Hc pathogenesis and provide the best model. We are exploring the potential benefits of humoral immunity against this fungus and generated several mAbs [to histone H2B and a heat shock protein 60kDa] that we tested for their protective efficacy after intraperitoneal administration.

Tube Thoracostomy

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2023

Source: Rachel Liu, BAO, MBBCh, Emergency Medicine, Yale School of Medicine, New Haven, Connecticut, USA Tube thoracostomy (chest tube placement) is a procedure during which a hollow tube is inserted into the thoracic cavity for drainage of fluid or air. Emergency chest tube insertion is performed for definitive treatment of tension pneumothorax, traumatic hemothorax, large-volume pleural effusions, and empyemas. Irrespective of the cause of air and fluid accumulation in the pleural space, the...

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