Rhombomere 5 6
Rhombomere 5 6 - Related Videos
14:40
Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV
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Cited by 2 •
2022
The role of RNA modifications in viral infections is just starting to be explored and could highlight new viral-host interaction mechanisms. In this work, we provide a pipeline to investigate m6A and m5C RNA modifications in the context of viral infections.
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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2025
This manuscript introduces a standardized protocol for a 5/6 nephrectomy by sharp bipolectomy via midline laparotomy in a rat model, aiming to induce a state of renal insufficiency via renal parenchyma reduction with a great degree of methodical precision and low risk of technical error.
07:52
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
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Cited by 41 •
2017
This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.
07:11
Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
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Cited by 5 •
2018
This article shows the method for the surgical placement in mice of an intraperitoneal catheter attached to an access port that is positioned at the back of the animal. Moreover, it explains the procedure for a 5/6 nephrectomy to resemble the uremic state of PD patients.
01:04
5-Number Summary
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2023
In a dataset, the 5-number summary includes the minimum data value, the data value of the first quartile, the median data value or data value of the second quartile, the data value of the third quartile, and the maximum data value. These 5 data values can be visualized as a box and whisker plot. In a box plot, the minimum and maximum data values represent the lower and upper whiskers in the graph, and the median is designated as the center of the box in the chart. The first quartile and third...
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Krox20/Egr2 acts as a segment-specific transcription factor that helps establish the identities and boundaries of rhombomeres 5 and 6. By regulating gene expression in these compartments, it contributes to regionally distinct patterns of neuronal differentiation, axon guidance, and neural crest migration. Its activity therefore links molecular patterning with the structural organization of the developing hindbrain and associated cranial tissues.
The boundaries provide positional information that allows neighboring embryonic hindbrain regions to follow different developmental programs. In rhombomeres 5 and 6, this compartmental organization supports distinct patterns of neuronal differentiation and helps coordinate the routes taken by axons and migrating neural crest cells. Maintaining regional identity is consequently important for organizing cranial structures and early neural circuitry.
Several coordinated processes are patterned within these segments, including the generation of distinct neuronal populations, guidance of developing axons, and migration of neural crest cells. These events are not independent: segment-specific gene expression supplies positional information that helps cells adopt regionally appropriate behaviors. Their coordination connects early hindbrain patterning with the formation of cranial nerves and craniofacial structures.
They provide a tractable example of how early tissue compartments can assign positional information and generate different cellular outcomes within a developing brain. Segment-specific molecular activity is associated with distinct neuronal differentiation patterns and coordinated cell movements. Studying these relationships helps developmental biologists connect gene expression domains with regional cell fate, neural circuit organization, and cranial development.
Researchers can focus on the relationship between segment-specific gene expression, rhombomere boundaries, neuronal differentiation, axon guidance, and neural crest migration. Examining these features together is more informative than considering any one process alone because the segments coordinate several developmental outcomes. This approach clarifies how positional information is translated into organized hindbrain circuits and forming cranial structures.
Their developmental significance arises from the connection between hindbrain patterning and neural crest migration, a process that contributes to forming cranial structures. Disrupting the positional information or regional cell behaviors associated with these segments could therefore alter cranial development. For this reason, rhombomeres 5 and 6 serve as a model for investigating molecular coordination underlying congenital craniofacial development.
Studies of these segments can address how transient embryonic compartments organize neural circuits, specify regional cell fates, and coordinate interactions between the hindbrain and migrating neural crest cells. They also provide context for examining how transcription factors such as Krox20/Egr2 connect gene regulation to tissue-level patterning. These questions make the model relevant to vertebrate brain development and cranial nerve formation.