Block Preconditioning

Block preconditioning is a class of numerical methods for solving large linear systems by grouping related unknowns into blocks and transforming the system to improve iterative solver performance. Rather than treating each variable independently, it applies approximate block inverses or block factorization to capture strong couplings within subsystems, reducing the condition number and accelerating convergence. Block preconditioners can use block-diagonal, block-triangular, or Schur-complement structures, depending on the system and available computational resources. In engineering, they are especially useful for sparse systems from finite-element models, computational fluid dynamics, structural mechanics, and multiphysics simulations, where efficient parallel solution directly affects modeling scale and runtime.

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JoVE EoE - Neurotherapeutics

Neuronal Adaptation to Repetitive Hypoxic Preconditioning in Mice

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2025

Source: Poinsatte, K., et al., Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice. J. Vis. Exp. (2015)This video demonstrates the method of repetitive hypoxic preconditioning (RHP) by exposing a mouse to controlled hypoxia cycles before inducing an ischemic stroke. The experiment evaluates its effects on blood-brain barrier stability, neuronal adaptation, and inflammation.

Research

JoVE Journal - Neuroscience
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Strategies for Study of Neuroprotection from Cold-preconditioning

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Cited by 17 •

2010

We seek to define the neural immune signaling responsible for cold-preconditioning as means to identify novel targets for therapeutics development to protect brain before injury onset. We present strategies for such work that require biological systems, experimental manipulations plus technical capacities that are highly reproducible and sensitive.

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

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Cited by 6 •

2012

In this study, we describe an improved protocol for a multiplexed high-throughput antibody microarray with lectin detection method that can be used in glycosylation profiling of specific proteins. This protocol features new reliable reagents and significantly reduces the time, cost, and lab equipment requirements as compared to the previous procedure.

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning

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Cited by 22 •

2015

The electroretinogram (ERG) is an electrical potential generated by the retina in response to light. This paper describes how to use the ERG to assess retinal function, in dark-adapted rats, and how it can be can be used to assess a neuroprotective intervention, in the present case remote ischemic preconditioning.

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

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Cited by 5 •

2017

Marrow stromal cells (MSCs) with neural potential exist within the bone marrow. Our protocol enriches this population of cells via hypoxic preconditioning and thereafter directs them to become mature Schwann cells.

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