Psoriasis Research
Psoriasis Research - Related Videos
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Cited by 26 •
2013
Psoriasis is a chronic, immune-mediated inflammatory skin disease. The Goeckerman regimen, formulated for the treatment of psoriasis, consists of exposure to ultraviolet B (UVB) light and application of crude coal tar (CCT). The following protocol is for the administration of Goeckerman therapy for the treatment of moderate-to-severe psoriasis.
02:28
Measuring Psoriasis Severity at Home
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2024
This paper details the creation of a Psoriasis Thickness Reference Card, enabling psoriasis patients to self-assess their psoriasis plaque thickness without the need for physician assistance. Additionally, the precision of self-assessment for psoriasis redness and scaliness by employing reference images depicting various skin tones is assessed.
06:34
SCAnED - An Open-source Skin Segmentation Macro for Semi-automated Cell and Nuclei Detection in Epidermal and Dermal Skin Compartments
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2025
Here, we present a semi-automated protocol for identifying and quantifying immune and non-immune cells in skin sections using SCAnED, a free ImageJ-based macro for skin segmentation.
08:04
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
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Cited by 8 •
2014
The protocol reported here allows the evaluation of the efficacy of photodynamic therapy (PDT) in cell lines and the optimization of the PDT settings before applying the therapy in animal models.
11:26
Imaging Neuronal Responses in Slice Preparations of Vomeronasal Organ Expressing a Genetically Encoded Calcium Sensor
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Cited by 12 •
2011
The vomeronasal organ (VNO) detects intraspecies chemical signals that convey social and reproductive information. We have performed Ca2+ imaging experiments using transgenic mice expressing G-CaMP2 in VNO tissue. This approach allows us to analyze the complicated response patterns of the vomeronasal neurons to large numbers of pheromone stimuli.
FAQs
Psoriasis research examines communication between immune cells and keratinocytes as a reinforcing inflammatory process. Dysregulated signals from these interacting cell populations can sustain abnormal tissue responses rather than allowing inflammation to resolve normally. Studying this exchange helps researchers connect cellular behavior with recurring lesions and identify signaling points that may serve as therapeutic targets or biomarker candidates.
The IL-23/IL-17 axis provides a focused framework for studying how inflammatory signaling contributes to psoriasis-associated tissue changes. Its activity helps explain how immune dysregulation can maintain abnormal responses in affected skin. Researchers therefore examine this pathway when evaluating disease mechanisms and developing targeted approaches intended to interrupt persistent inflammation more precisely than nonspecific strategies.
Barrier disruption links psoriasis research to host-defense questions because damaged skin can alter the interface between tissue and its environment. Immunology and infection studies consider how this compromised barrier interacts with inflammatory signaling and may contribute to secondary complications. This context is also important when assessing treatment-related infection risks alongside efforts to control inflammation.
Psoriasis research can generate information about genetic susceptibility, environmental triggers, immune-cell activity, keratinocyte responses, and inflammatory pathways. Together, these findings help characterize why disease activity persists and how systemic health may be affected. They also support the search for biomarkers, which can improve the ability to connect biological changes with disease processes and treatment considerations.
By tracing dysregulated communication and pathways such as the IL-23/IL-17 axis, researchers can identify biological processes suitable for targeted intervention. The goal is to address drivers of persistent inflammation rather than rely only on broad descriptions of skin changes. Research findings can also inform strategies that balance inflammatory control with attention to treatment-related infection risks.
Psoriasis provides a context for examining how immune-mediated inflammation, tissue barriers, and host defense influence one another. Research in this area can clarify how disrupted skin and inflammatory signaling shape susceptibility to secondary complications, while also showing why therapies must be evaluated for infection-related consequences. These connections extend psoriasis research beyond dermatologic findings to broader systemic health questions.