Tail Cuff Plethysmography
Tail Cuff Plethysmography - Related Videos
08:54
Measuring Blood Pressure in Mice using Volume Pressure Recording, a Tail-cuff Method
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Cited by 175 •
2009
The CODA 8-Channel High Throughput Non-Invasive Blood Pressure system measures the blood pressure in up to 8 mice or rats simultaneously. This tail-cuff system uses Volume Pressure Recording (VPR) to measure the blood pressure by determining the tail blood volume.
02:00
Simultaneous Plethysmography and Electromyography Recording in an ALS Mouse Model
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2025
Source: Jensen, V. N., et al. Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease. J. Vis. Exp. (2017).This video demonstrates the method for recording simultaneous plethysmography and electromyography signals in a freely moving ALS mouse model. The procedure involves using implanted electrodes and a transmitter to capture muscle activity, alongside a plethysmography chamber to monitor breathing patterns, to investigate the role of...
08:51
Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography
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Cited by 70 •
2014
The assessment of respiratory physiology has traditionally relied upon techniques, which require restraint or sedation of the animal. Unrestrained whole-body plethysmography, however, provides precise, non-invasive, quantitative analysis of respiratory physiology in animal models. In addition, the technique allows repeated respiratory assessment of mice allowing for longitudinal studies.
10:17
The Tail Suspension Test
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Cited by 534 •
2012
The tail-suspension test is validated as an experimental procedure to assess antidepressant efficacy of drug treatments in mice. Mice are suspended by their tails for six minutes and escape-related behaviors are assessed. We describe procedures used in conducting the tail suspension test.
13:19
Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique
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Cited by 6 •
2017
Among abdominal solid organ transplantation, pancreatic grafts are prone to develop severe ischemia reperfusion injury-associated graft damage, leading eventually to early graft loss. This protocol describes a model of murine pancreas transplantation using a non-suture cuff technique, ideally suited for analyzing these early, deleterious damages.
FAQs
The key measurement event occurs as cuff pressure falls after the tail artery has been temporarily occluded. A sensor identifies the return of blood flow, and the pressure at that point supports estimation of systolic pressure. This pressure-flow relationship connects a controlled external pressure change with an arterial measurement without requiring surgical access.
The detected signal also reflects pulse-related changes in blood volume. These fluctuations provide related hemodynamic information, so the output can be considered alongside pressure rather than treated as a single isolated number. In infection or inflammation studies, that broader signal may help characterize cardiovascular effects associated with immune activity or experimental treatment.
Measurement conditions can influence the reliability of tail cuff results, making restraint, warming, and animal acclimatization important parts of the approach. These conditions prepare the animal for the measurement and support consistent detection of blood flow returning during cuff deflation. Attention to them is especially important when comparing cardiovascular measurements across repeated observations.
A typical measurement places the cuff and blood-flow sensor on the rodent’s tail after the animal has been appropriately warmed and acclimatized. The cuff is inflated to temporarily occlude the tail artery, then pressure is reduced while the sensor detects returning flow. The recorded pressure-flow response is used to estimate systolic pressure and related parameters.
Tail cuff plethysmography is useful when researchers need to follow cardiovascular changes associated with pathogens, inflammatory responses, immune mediators, or experimental treatments. Because measurements can be repeated without surgical catheterization, the method supports longitudinal designs that track hemodynamic changes over time in the same laboratory rodents.
Its main practical advantage over surgical catheterization is that it does not require surgical access. This makes repeated measurements feasible during longitudinal experiments, including studies examining changing cardiovascular effects of infection, inflammation, or treatment. However, reliable use still depends on appropriate restraint, warming, and acclimatization during each measurement session.