Acquired Brain Injury
Acquired Brain Injury - Related Videos
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
11:04
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
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Cited by 125 •
2011
Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.
02:14
Delivery of a Traumatic Brain Injury to a Mouse Brain
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2025
This video demonstrates the delivery of Traumatic Brain Injury (TBI) in mice. After exposing the skull, the TBI site is marked. The mouse is then positioned under the TBI device. The impact is delivered by lifting the metal rod and allowing it to drop freely onto the impactor, which is in contact with the skull.
12:28
Using Diffusion Tensor Imaging in Traumatic Brain Injury
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2023
Source: Laboratories of Jonas T. Kaplan and Sarah I. Gimbel—University of Southern California Traditional brain imaging techniques using MRI are very good at visualizing the gross structures of the brain. A structural brain image made with MRI provides high contrast of the borders between gray and white matter, and information about the size and shape of brain structures. However, these images do not detail the underlying structure and integrity of white matter networks in the brain, which...
05:30
Controlled Cortical Impact Model for Traumatic Brain Injury
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Cited by 87 •
2014
Traumatic brain injuries (TBIs) remain a serious health problem. Using the controlled cortical impact surgery model, research on the effects of TBI and possible treatment methods may be performed.
FAQs
These mechanisms can affect the brain through different pathways. Traumatic events may directly disrupt tissue, whereas non-traumatic conditions can impair blood flow or trigger inflammation. Because these processes can alter movement, cognition, communication, behavior, or consciousness, identifying the underlying mechanism helps clinicians connect the injury’s cause with its neurological effects and plan further evaluation.
The clinical effects depend on how the injury affects brain function. One patient may show prominent movement changes, while another may experience cognitive or communication difficulties, behavioral changes, or altered consciousness. This range means clinicians must consider several functional domains rather than relying on a single symptom when evaluating the consequences of brain damage.
Cause provides an important framework for interpreting the injury. Falls and collisions suggest traumatic mechanisms involving direct tissue disruption, while stroke, infection, tumors, or oxygen deprivation represent non-traumatic causes associated with other processes, including impaired blood flow or inflammation. Linking cause and mechanism supports more focused diagnosis, prognosis, and rehabilitation planning.
Neurological assessment and imaging provide complementary information for clinical decision-making. Together, they support accurate diagnosis and help clinicians evaluate the consequences of brain injury in relation to movement, cognition, communication, behavior, and consciousness. Their findings also contribute to prognosis and help guide rehabilitation planning rather than treating diagnosis as an isolated endpoint.
Evaluation connects observed neurological effects with the patient’s likely rehabilitation needs. Clinicians use neurological assessment and imaging to support diagnosis and prognosis, then apply that information when planning interventions for functional recovery and long-term disability management. This approach helps align rehabilitation with the patient’s impairments and supports better quality-of-life goals for patients and families.
In medicine, ABI knowledge supports diagnosis, prognosis, rehabilitation planning, and management of long-term disability. Research examines interventions intended to promote functional recovery and improve quality of life. The field therefore extends beyond identifying brain damage: it connects clinical evaluation with ongoing care, recovery strategies, and support for patients and their families.