Mouse Fetal Alcohol Model
Mouse Fetal Alcohol Model - Related Videos
10:07
Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
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Cited by 34 •
2012
In order to understand the molecular mechanisms of the ethanol-induced developmental damage, we have developed a zebrafish model of ethanol exposure and are exploring the physical, cellular, and genetic alterations that occur after ethanol exposure1. We then seek to find potential interventions and rapidly test them in this animal model.
09:20
A Mouse Fetal Skin Model of Scarless Wound Repair
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Cited by 24 •
2015
During mammalian development, early gestational skin wounds heal without a scar. Here we detail a reliable and reproducible model of fetal scarless wound healing in the cutaneous dorsum of E16.5 (scarless) and E18.5 (scarring) mouse embryos.
03:56
Modeling Transuterine Fetal Tracheal Occlusion in Murine Model: A Surgical Procedure for Ligation of the Fetal Trachea Within a Pregnant Mouse
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2025
This video demonstrates the transuterine tracheal occlusion procedure of a mouse fetus in a pregnant mouse. This model can be used to study the impact of occluded trachea on lung development.
19:57
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
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Cited by 4 •
2017
Trace eyeblink classical conditioning (ECC) was used to assess hippocampal-dependent associative learning in adult rats that were administered a high concentration (11.9% v/v) of alcohol during early neonatal brain development. In general, ECC procedures are sound diagnostic tools for detecting brain dysfunction across many psychological and biomedical settings.
10:12
A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
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Cited by 8 •
2012
We developed a novel surgical approach for intratracheal administration of bioactive agents into the mouse fetus. The delivery route is more efficient in targeting the fetal mouse lungs than the commonly used intra-amniotic injection. This procedure has to date not been described in a mouse model.
FAQs
Researchers vary when and how much ethanol pregnant mice receive to connect exposure conditions with developmental outcomes. This design helps distinguish effects associated with particular gestational stages from those associated with overall dose. Comparing groups across these variables can reveal periods of heightened vulnerability in growth, organ formation, brain development, or later behavior.
The model supports analysis of how prenatal alcohol exposure disrupts cellular signaling and tissue organization during development. These processes may be examined alongside changes in embryonic or fetal growth and organ formation. Linking molecular or structural alterations with developmental outcomes helps researchers investigate how an exposure during pregnancy can produce lasting medical consequences in offspring.
Brain development provides one outcome through which researchers can examine the developmental effects of prenatal ethanol exposure, together with growth, organ formation, and later behavior. Studying these endpoints in the same experimental system allows exposure conditions to be related to both early developmental changes and longer-term consequences relevant to fetal alcohol spectrum disorders.
A typical study begins by administering ethanol to pregnant mice during a defined stage of gestation and at a specified dose. Researchers then examine embryonic or fetal development and may assess offspring behavior later. Measurements can be related back to the exposure conditions, creating a controlled framework for evaluating developmental injury and potential biological mechanisms.
The model can be used to evaluate changes in growth, organ formation, brain development, and offspring behavior. Researchers may also investigate altered cellular signaling and tissue organization as biological correlates of injury. Considering these outcomes together provides a broader view of how prenatal alcohol exposure affects development rather than relying on a single measurement.
In medicine, the system helps investigators study the biological basis of alcohol-related developmental injury and identify potential biomarkers, preventive strategies, and treatments. Because exposure timing and dose can be defined experimentally, findings can be compared with developmental outcomes under controlled conditions and may inform clinical research on pregnancy-related alcohol exposure and its long-term consequences.