Ovarian Tumor
Ovarian Tumor - Related Videos
10:35
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
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Cited by 18 •
2010
To study in vivo tumor growth and tumor microenvironment, we used a syngeneic and orthotopic mouse model of ovarian cancer in immunocompetent animals. We transduced a mouse tumor cell line (MOV1) with Katushka fluorescent protein (MOV1KAT) and here we show its orthotopic implantation in ovary and in vivo imaging.
11:37
In vitro Enrichment of Ovarian Cancer Tumor-initiating Cells
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Cited by 30 •
2015
Tumor-initiating cells (TICs) may represent a viable therapeutic target for the treatment of ovarian cancer, a highly recurrent and fatal disease. We present a protocol for culture conditions that enrich for this highly tumorigenic population of cells.
04:35
Obtaining Primary Ovarian Cancer Cells from Solid Specimens: A Method to Culture Epithelial Ovarian Cancer Cells from Ovarian Tumor Specimens
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2023
In this video, we describe a method for isolating and characterizing primary ovarian cancer cells from solid ovarian tumor tissue specimens. The epithelial cancer cells obtained using this protocol are suitable for understanding the processes that may lead to ovarian cancer initiation and development.
04:13
Modeling Ovarian Cancer Communication for Imaging Mass Spectrometry Analysis: A Method to Identify Small Molecule Chemical Communicators in Metastatic Ovarian Tumor Development
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2023
This protocol describes a technique for sample preparation by co-culturing ovarian explants with the fallopian tube cancer cells. These samples are visualized using imaging mass spectroscopy, or IMS, to detect small molecule exchange between the cells and tissues leading to tumor development.
10:45
Clinically Relevant Transplantable Tumor Models for Studying Metastatic Ovarian Cancer and Therapeutic Response in Mouse
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2026
Here we present a step-by-step protocol for establishing the intraperitoneal and the intrabursal tumor models to study ovarian cancer cancer progression, metasatsis, and therapeutic response. Further, we describe how to use luciferase-based non-invasive in vivo imaging in these models to monitor tumor progression in mouse.
FAQs
Changes affecting proliferation, survival, and differentiation can remove the controls that normally regulate ovarian cells. As these controls become disrupted, cells may continue accumulating rather than responding appropriately to signals that limit growth or maintain specialized functions. This imbalance permits formation of a mass and helps explain why examining tumor biology is important for classification and treatment planning.
The key distinction is biological behavior. Benign masses do not exhibit the malignant pattern of invading nearby tissues or spreading to distant sites, whereas malignant tumors can acquire both capabilities. Assessing these characteristics, together with tumor type and extent, helps clinicians determine the seriousness of disease and select an appropriate management strategy.
Tumor type identifies the biological category of the growth, while extent describes how far the disease has progressed. These factors provide a framework for estimating clinical significance and selecting treatment. Because ovarian tumors can differ substantially in behavior, classification connects diagnostic findings with decisions about surgical removal, systemic therapy, and further assessment.
Evaluation combines several complementary sources of evidence rather than relying on one finding. Clinicians consider symptoms and pelvic examination results, use imaging to assess the mass and its distribution, measure laboratory biomarkers, and examine tissue histopathologically. Together, these methods help determine the tumor type and extent, which are central to management decisions.
Histopathological analysis examines the tumor’s tissue characteristics and contributes directly to classification. When interpreted alongside symptoms, examination, imaging, and laboratory biomarkers, it helps distinguish relevant tumor categories and clarify disease extent. This integrated interpretation supports decisions about surgical removal or systemic therapy instead of basing treatment on appearance or a single laboratory result.
Clinicians use the combined classification and extent assessment to plan management, which may include surgical removal and systemic therapies. In research, studying tumor biology aims to improve earlier detection, refine prognostic assessment, and identify more precise targeted treatment strategies. These goals connect laboratory investigation with more individualized approaches to ovarian tumor care.