Brain Hemisphere Injury
Brain Hemisphere Injury - Related Videos
03:00
Recording of Local Field Potential from Both Hemispheres of the Mouse Brain
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2025
This video demonstrates in vivo recording of local field potential (LFP) from bilateral M2 areas of the mouse brain. An anesthetized mouse is secured and prepared for the procedure. To record LFPs, insert microelectrodes into the target coordinates of the bilateral M2 areas, which are responsible for complex motor movements.
11:04
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
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Cited by 125 •
2011
Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.
02:14
Delivery of a Traumatic Brain Injury to a Mouse Brain
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2025
This video demonstrates the delivery of Traumatic Brain Injury (TBI) in mice. After exposing the skull, the TBI site is marked. The mouse is then positioned under the TBI device. The impact is delivered by lifting the metal rod and allowing it to drop freely onto the impactor, which is in contact with the skull.
04:19
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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Cited by 16 •
2017
Athletes absorb several hundred mild traumatic brain injuries (mTBI)/concussions every year; however, the consequence of these on the brain is poorly understood. Therefore, an animal model of single and repetitive mTBI that consistently replicates clinically relevant symptoms provides the means to advance the study of mTBI and concussion.
05:47
Repetitive Transcranial Magnetic Stimulation to the Unilateral Hemisphere of Rat Brain
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Cited by 10 •
2016
We applied repetitive transcranial magnetic stimulation (rTMS) to the unilateral hemisphere of rat brain, by placing a 25-mm figure-8 coil 1 cm lateral to the vertex on the biauricular line and angulating the coil by 45°. An in-house water cooling system was used for rTMS for more than 20 min.
FAQs
Damage can interrupt communication among neurons, reducing the coordination needed for movement, sensation, language, memory, or other higher functions. The initial disruption may be compounded by swelling and altered network activity, which can temporarily or persistently impair how remaining circuits operate. This network-level view explains why effects may extend beyond the immediately damaged region.
Outcomes vary because different regions support different functions, while larger lesions can affect more extensive circuitry. Timing also matters because swelling and changing network activity may alter function as the injury evolves. Considering these variables helps neuroscientists interpret differences between individuals rather than linking every impairment to hemisphere involvement alone.
Recovery may involve support from the intact hemisphere or from networks that remain functional after damage. Studying these changes provides evidence about neuroplasticity, the capacity of neural systems to reorganize or adapt following injury. This perspective shifts attention from the damaged area alone toward interactions among surviving circuits and their changing contribution to function.
These approaches provide complementary information. Neurological assessment characterizes observed impairments, brain imaging identifies the injury and its anatomical context, and functional testing examines effects on behavior or cognition. Together, they help relate affected brain regions to specific abilities and provide a structured basis for tracking functional changes over time.
Evaluation combines neurological assessment with brain imaging and functional testing rather than relying on a single measure. Clinicians or researchers first characterize disrupted abilities, then examine the injury’s location and extent, and finally relate those findings to behavior or cognition. Repeated assessment can help describe changing function as swelling or network activity changes.
In rehabilitation, assessment findings help identify disrupted functions and inform strategies intended to support recovery. In neuroscience research, the same evidence is used to investigate neuroplasticity, recovery, and the contributions of the intact hemisphere or remaining networks. These applications connect individual functional outcomes with broader questions about how the brain responds to damage.