Substance Use Disorders

Substance use disorders are chronic psychological conditions characterized by compulsive substance use, impaired control, and continued use despite harmful consequences. They develop through interactions among brain reward pathways, learning, stress, and environmental influences; repeated exposure can strengthen cue-driven cravings and produce tolerance, withdrawal, and persistent changes in behavior. In psychology, clinicians assess substance use patterns, co-occurring mental health concerns, motivation, and social context to guide interventions such as cognitive behavioral therapy, motivational interviewing, and relapse-prevention planning. Studying these disorders supports earlier identification, individualized treatment, harm reduction, and improved understanding of how biological and psychological factors shape recovery.

Substance Use Disorders - Related Videos

Education

JoVE Core - Introduction to Psychology

Substance Use Disorders Affecting Sleep

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2024

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue. Understanding the concepts of physical dependence,...

Deleterious Substances in Aggregate

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2024

Deleterious substances in aggregates can be detrimental to the quality and durability of concrete. These substances include organic impurities like loam, which interfere with cement hydration and are usually present in the sand. These prevent a good bond between aggregate and cement paste. Organic impurities can be detected using the colorimetric test, where the darkness of a solution after agitation indicates the level of organic content. Another type of impurity is clay and fine material that...

Research

JoVE EoE - Neurotherapeutics

Targeted Substance Delivery to the Mouse Brain via Infusion into the Internal Carotid Artery

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2025

Source: Leda, A. R., et al. Mouse Microsurgery Infusion Technique for Targeted Substance Delivery into the CNS via the Internal Carotid Artery. J. Vis. Exp. (2017)This video demonstrates a microsurgical procedure designed to facilitate the targeted infusion of a test substance into the brain via the internal carotid artery (ICA). The procedure involves precise suturing and vascular manipulation to temporarily restrict blood flow, ensuring controlled delivery. A capillary tube is inserted into...

Intrinsically Disordered Proteins

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2020

Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...

Education

JoVE Core - Anatomy and Physiology
Free Sample

Connective Tissue Fibers and Ground Substance

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2025

One of the significant functions of connective tissue is connecting tissues and organs. Unlike epithelial tissue that is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. The matrix usually includes a large amount of extracellular material produced by the connective tissue cells that are embedded within it. It plays a significant role in the functioning of this tissue. The major component of the matrix is a...

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