Un modelo estandarizado de xenotrasplante cardíaco heterotópico de cerdo a macaco

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Citado por 1

06:52 min.

4 de noviembre de 2025

10.3791/68757-v

4 de noviembre de 2025

910 visualizaciones

Yuan Chang¹^,²^,³ , Kai Xing¹^,²^,³ , Xiumeng Hua¹^,²^,³ , Jiangping Song¹^,²^,³^,⁴^,⁵^,⁶

¹Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, ²Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, ³Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, ⁴Department of Cardiac Surgery, Fuwai Yunnan Hospital, Chinese Academy of Medical Sciences, Affiliated Cardiovascular Hospital of Kunming Medical University, ⁵Shenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, ⁶Sanya Institute of China Agricultural University

Este estudio presenta un modelo preclínico de xenotrasplante cardíaco abdominal heterotópico utilizando cerdos y macacos knockout α-Gal (GTKO). El modelo incorpora una selección optimizada del receptor, técnicas de anastomosis vascular y estrategias de manejo perioperatorio. Es adecuado para evaluar nuevos agentes inmunosupresores y proporciona una plataforma conveniente para avanzar en el xenotrasplante cardíaco.