Arie Horowitz Department of Medicine, Cardeza Vascular Research Center Sidney Kimmel Medical College, Thomas Jefferson University Biography Publications Institution JoVE Articles Arie Horowitz Dr. Arie Horowitz is an associate professor at the Cardeza Center for Vascular Biology Research at the Sydney Kimmel Medical College of Thomas Jefferson University. He holds a secondary appointment in the Department of Cancer Biology at the same college. The focus of the Horowitz laboratory is on vascular biology in general and on the molecular mechanisms that regulate vascular permeability in particular. The laboratory uses cell culture and mouse models to understand the homeostasis of the junctions between endothelial cells and their response to factors that disrupt them. He has addressed recently also the underlying pathophysiological and molecular mechanisms of congenital hydrocephalus. His research has been supported by grants from the National Hear Lung and Blood institute, and from the American Heart Association. He published close to fifty peer-reviewed original research and review articles, as well as editorials and book chapters.Dr. Horowitz received his M.Sc. and D.Sc. degrees in bioengineering at the Israel Institute of Technology. He joined the Thomas Jefferson University faculty in late 2015, after holding faculty positions at the Dartmouth College School of Medicine and the Lerner Research Institute of the Cleveland Clinic. In addition to research, Dr. Horowitz teaches graduate and medical school students. Publications Letter by Horowitz Regarding Article, "Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability" Circulation Research. Mar, 2017 | Pubmed ID: 28254807 The Versatility of RhoA Activities in Neural Differentiation Small GTPases. Jan, 2017 | Pubmed ID: 28125332 RhoA Inhibits Neural Differentiation in Murine Stem Cells Through Multiple Mechanisms Science Signaling. Jul, 2016 | Pubmed ID: 27460990 The Cytoplasmic Domain of Neuropilin-1 Regulates Focal Adhesion Turnover FEBS Letters. Nov, 2013 | Pubmed ID: 24021649 VEGF and Angiopoietin-1 Exert Opposing Effects on Cell Junctions by Regulating the Rho GEF Syx The Journal of Cell Biology. Dec, 2012 | Pubmed ID: 23253477 Stimulus-dependent Phosphorylation of Profilin-1 in Angiogenesis Nature Cell Biology. Oct, 2012 | Pubmed ID: 23000962 Regulation of VEGF Signaling by Membrane Traffic Cellular Signalling. Sep, 2012 | Pubmed ID: 22617029 Membrane Traffic As a Coordinator of Cell Migration and Junction Remodeling Communicative & Integrative Biology. Nov, 2011 | Pubmed ID: 22446532 Rab13-dependent Trafficking of RhoA is Required for Directional Migration and Angiogenesis The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21543326 Imaging of Growth Factor-augmented Angiogenesis After Myocardial Infarction: Glimmers of a Spatiotemporal Pattern? Journal of Molecular and Cellular Cardiology. Jun, 2010 | Pubmed ID: 19913025 Branching Morphogenesis Circulation Research. Jan, 2009 | Pubmed ID: 19179661 The Amot/Patj/Syx Signaling Complex Spatially Controls RhoA GTPase Activity in Migrating Endothelial Cells Blood. Jan, 2009 | Pubmed ID: 18824598 Cleavage of Syndecan-4 by ADAMTS1 Provokes Defects in Adhesion The International Journal of Biochemistry & Cell Biology. Apr, 2009 | Pubmed ID: 18775505 Branching Morphogenesis Circulation Research. Oct, 2008 | Pubmed ID: 18845818 Syx, a RhoA Guanine Exchange Factor, is Essential for Angiogenesis in Vivo Circulation Research. Sep, 2008 | Pubmed ID: 18757825 Vascular Endothelial Growth Factor and Semaphorin Induce Neuropilin-1 Endocytosis Via Separate Pathways Circulation Research. Sep, 2008 | Pubmed ID: 18723443 Binding of Internalized Receptors to the PDZ Domain of GIPC/synectin Recruits Myosin VI to Endocytic Vesicles Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16908842 Selective Regulation of Arterial Branching Morphogenesis by Synectin Developmental Cell. Jun, 2006 | Pubmed ID: 16740480 A PDZ-binding Motif As a Critical Determinant of Rho Guanine Exchange Factor Function and Cell Phenotype Molecular Biology of the Cell. Apr, 2006 | Pubmed ID: 16467373 Fibroblast Growth Factor-specific Modulation of Cellular Response by Syndecan-4 The Journal of Cell Biology. May, 2002 | Pubmed ID: 12011116 Protein Kinase C (PKC) Delta Regulates PKCalpha Activity in a Syndecan-4-dependent Manner The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11916978 Analyse af retinoidsyre-induceret Neural Differentiation af muse embryonale stamceller i to og tre-dimensionelle embryoide legemer Junning Yang1, Chuanshen Wu2, Ioana Stefanescu1, Arie Horowitz1,3 1Department of Medicine, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University, 2Department of Molecular Cardiology, Cleveland Clinic Foundation, 3Department of Cancer Biology, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University JoVE 55621 Biologie du développement
Analyse af retinoidsyre-induceret Neural Differentiation af muse embryonale stamceller i to og tre-dimensionelle embryoide legemer Junning Yang1, Chuanshen Wu2, Ioana Stefanescu1, Arie Horowitz1,3 1Department of Medicine, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University, 2Department of Molecular Cardiology, Cleveland Clinic Foundation, 3Department of Cancer Biology, Cardeza Vascular Research Center, Sidney Kimmel Medical College, Thomas Jefferson University JoVE 55621 Biologie du développement