Bart Spee Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine Utrecht University Biography Publications Institution JoVE Articles Bart Spee has not added a biography. If you are Bart Spee and would like to personalize this page please email our Author Liaison for assistance. Publications Surgical Resection and Radiofrequency Ablation Initiate Cancer in Cytokeratin-19+- Liver Cells Deficient for P53 and Rb Oncotarget. Jun, 2016 | Pubmed ID: 27323406 ATGL and DGAT1 Are Involved in the Turnover of Newly Synthesized Triacylglycerols in Hepatic Stellate Cells Journal of Lipid Research. Jul, 2016 | Pubmed ID: 27179362 The Menkes and Wilson Disease Genes Counteract in Copper Toxicosis in Labrador Retrievers: a New Canine Model for Copper-metabolism Disorders Disease Models & Mechanisms. Jan, 2016 | Pubmed ID: 26747866 Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow Stem Cells and Development. Jan, 2016 | Pubmed ID: 26462417 Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids Stem Cell Reports. Oct, 2015 | Pubmed ID: 26455412 Role of Long-chain Acyl-CoA Synthetase 4 in Formation of Polyunsaturated Lipid Species in Hepatic Stellate Cells Biochimica Et Biophysica Acta. Feb, 2015 | Pubmed ID: 25500141 Aberrant Expression of Copper Associated Genes After Copper Accumulation in COMMD1-deficient Dogs Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS). Jan, 2015 | Pubmed ID: 25053573 Enhanced Wnt/β-catenin and Notch Signalling in the Activated Canine Hepatic Progenitor Cell Niche BMC Veterinary Research. Dec, 2014 | Pubmed ID: 25551829 Classification of Primary Hepatic Tumours in the Cat Veterinary Journal (London, England : 1997). Nov, 2014 | Pubmed ID: 25439443 Hepatic Progenitor Cells in Canine and Feline Medicine: Potential for Regenerative Strategies BMC Veterinary Research. Jun, 2014 | Pubmed ID: 24946932 Aberrant Expression and Distribution of Enzymes of the Urea Cycle and Other Ammonia Metabolizing Pathways in Dogs with Congenital Portosystemic Shunts PloS One. 2014 | Pubmed ID: 24945279 Keratin 19: a Key Role Player in the Invasion of Human Hepatocellular Carcinomas Gut. Apr, 2014 | Pubmed ID: 23958557 Potential of Regenerative Medicine Techniques in Canine Hepatology The Veterinary Quarterly. Dec, 2013 | Pubmed ID: 24422896 Classification of Primary Hepatic Tumours in the Dog Veterinary Journal (London, England : 1997). Sep, 2013 | Pubmed ID: 24011584 Safety and Efficacy Field Study of Artesunate for Dogs with Non-resectable Tumours Anticancer Research. May, 2013 | Pubmed ID: 23645726 Altered Subcellular Localization of Heat Shock Protein 90 is Associated with Impaired Expression of the Aryl Hydrocarbon Receptor Pathway in Dogs PloS One. 2013 | Pubmed ID: 23472125 Aberrant Gene Expression in Dogs with Portosystemic Shunts PloS One. 2013 | Pubmed ID: 23451256 COMMD1-deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis PloS One. 2012 | Pubmed ID: 22879914 Macrophage-derived Wnt Opposes Notch Signaling to Specify Hepatic Progenitor Cell Fate in Chronic Liver Disease Nature Medicine. Apr, 2012 | Pubmed ID: 22388089 Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors Gastroenterology. Apr, 2012 | Pubmed ID: 22178589 Recombinant Hepatocyte Growth Factor Treatment in a Canine Model of Congenital Liver Hypoplasia Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2011 | Pubmed ID: 21733083 Keratin 19 Marks Poor Differentiation and a More Aggressive Behaviour in Canine and Human Hepatocellular Tumours Comparative Hepatology. Feb, 2010 | Pubmed ID: 20167095 Characterisation of the Liver Progenitor Cell Niche in Liver Diseases: Potential Involvement of Wnt and Notch Signalling Gut. Feb, 2010 | Pubmed ID: 19880964 Cross-species Immunohistochemical Investigation of the Activation of the Liver Progenitor Cell Niche in Different Types of Liver Disease Liver International : Official Journal of the International Association for the Study of the Liver. Sep, 2009 | Pubmed ID: 19490419 A GeNorm Algorithm-based Selection of Reference Genes for Quantitative Real-time PCR in Skin Biopsies of Healthy Dogs and Dogs with Atopic Dermatitis Veterinary Immunology and Immunopathology. May, 2009 | Pubmed ID: 19131113 The Dog Liver Contains a "side Population" of Cells with Hepatic Progenitor-like Characteristics Stem Cells and Development. Mar, 2009 | Pubmed ID: 18680393 In Vitro Differentiation of Liver Progenitor Cells Derived from Healthy Dog Livers Stem Cells and Development. Mar, 2009 | Pubmed ID: 18454698 Clinicopathological Study on Cholangiolocellular Carcinoma Suggesting Hepatic Progenitor Cell Origin Hepatology (Baltimore, Md.). May, 2008 | Pubmed ID: 18393293 In Vitro and in Vivo Bioactivity of Recombinant Canine Hepatocyte Growth Factor Veterinary Journal (London, England : 1997). Oct, 2008 | Pubmed ID: 18314358 Hepatocyte Growth Factor Improves Viability After H2O2-induced Toxicity in Bile Duct Epithelial Cells Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. Apr, 2008 | Pubmed ID: 18234561 Major HGF-mediated Regenerative Pathways Are Similarly Affected in Human and Canine Cirrhosis Comparative Hepatology. Jul, 2007 | Pubmed ID: 17672890 Copper Metabolism and Oxidative Stress in Chronic Inflammatory and Cholestatic Liver Diseases in Dogs Journal of Veterinary Internal Medicine. Sep-Oct, 2006 | Pubmed ID: 17063700 Specific Down-regulation of XIAP with RNA Interference Enhances the Sensitivity of Canine Tumor Cell-lines to TRAIL and Doxorubicin Molecular Cancer. Sep, 2006 | Pubmed ID: 16953886 Development and Evaluation of Canine Reference Genes for Accurate Quantification of Gene Expression Analytical Biochemistry. Sep, 2006 | Pubmed ID: 16844072 Transforming Growth Factor Beta-1 Signalling in Canine Hepatic Diseases: New Models for Human Fibrotic Liver Pathologies Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2006 | Pubmed ID: 16842329 Regenerative and Fibrotic Pathways in Canine Hepatic Portosystemic Shunt and Portal Vein Hypoplasia, New Models for Clinical Hepatocyte Growth Factor Treatment Comparative Hepatology. Dec, 2005 | Pubmed ID: 16336649 Quantitative PCR Method to Detect a 13-kb Deletion in the MURR1 Gene Associated with Copper Toxicosis and HIV-1 Replication Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jun, 2005 | Pubmed ID: 16075372 Differential Expression of Copper-associated and Oxidative Stress Related Proteins in a New Variant of Copper Toxicosis in Doberman Pinschers Comparative Hepatology. Mar, 2005 | Pubmed ID: 15790412 The Establishment and Characterization of the First Canine Hepatocellular Carcinoma Cell Line, Which Resembles Human Oncogenic Expression Patterns Comparative Hepatology. Nov, 2004 | Pubmed ID: 15566568 Detection of Helicobacter Pylori in Bile of Cats FEMS Immunology and Medical Microbiology. Nov, 2004 | Pubmed ID: 15477044 Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins Loes A. Oosterhoff1, Hedwig S. Kruitwagen1, Bart Spee1, Frank G. van Steenbeek1 1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University JoVE 54786 Médecine
Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins Loes A. Oosterhoff1, Hedwig S. Kruitwagen1, Bart Spee1, Frank G. van Steenbeek1 1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University JoVE 54786 Médecine