Christopher S. Thom Division of Neonatology Children’s Hospital of Philadelphia Biography Publications Institution JoVE Articles Christopher S. Thom has not added a biography. If you are Christopher S. Thom and would like to personalize this page please email our Author Liaison for assistance. Publications Modeling Primitive and Definitive Erythropoiesis with Induced Pluripotent Stem Cells Blood Advances. Mar, 2024 | Pubmed ID: 38290102 Quantitative Label-free Mass Spectrometry Reveals Content and Signaling Differences Between Neonatal and Adult Platelets Journal of Thrombosis and Haemostasis : JTH. Dec, 2023 | Pubmed ID: 38160730 Phosphoproteomics Reveals Content and Signaling Differences Between Neonatal and Adult Platelets BioRxiv : the Preprint Server for Biology. Sep, 2023 | Pubmed ID: 37745418 Tropomyosin 1 Deficiency Facilitates Cell State Transitions to Enhance Hemogenic Endothelial Cell Specification During Hematopoiesis BioRxiv : the Preprint Server for Biology. Sep, 2023 | Pubmed ID: 37693628 Neonatal Thrombocytopenia As a Presenting Finding in De Novo Pyruvate Kinase Deficiency Neonatology. 2023 | Pubmed ID: 37473739 Generation of a Human Tropomyosin 1 Knockout IPSC Line Stem Cell Research. Sep, 2023 | Pubmed ID: 37422949 Mendelian Randomization Analyses Clarify the Effects of Height on Cardiovascular Diseases MedRxiv : the Preprint Server for Health Sciences. May, 2023 | Pubmed ID: 37205563 Generation of a Human Knockout IPSC Line BioRxiv : the Preprint Server for Biology. May, 2023 | Pubmed ID: 37205377 Genetically Influenced Tobacco and Alcohol Use Behaviors Impact Erythroid Trait Variation MedRxiv : the Preprint Server for Health Sciences. May, 2023 | Pubmed ID: 37205362 TSABL: Trait Specific Annotation Based Locus Predictor BMC Genomics. Jun, 2022 | Pubmed ID: 35705896 Body Mass Index and Adipose Distribution Have Opposing Genetic Impacts on Human Blood Traits ELife. Feb, 2022 | Pubmed ID: 35166671 High Rate of Extreme Thrombocytosis Indicates Bone Marrow Hyperactivity and Splenic Dysfunction Among Congenital Diaphragmatic Hernia Patients Platelets. Jul, 2022 | Pubmed ID: 34697983 Thrombocytosis in an Infant with a Mutation: a Case Report Platelets. Apr, 2021 | Pubmed ID: 32319342 Mechanistic and Translational Advances Using IPSC-Derived Blood Cells Journal of Experimental Pathology. 2020 | Pubmed ID: 33768218 Airway Emergency Management in a Pediatric Hospital Before and During the COVID-19 Pandemic International Journal of Pediatric Otorhinolaryngology. Dec, 2020 | Pubmed ID: 33130467 Airway Emergency Management in a Pediatric Hospital Before and During the COVID-19 Pandemic MedRxiv : the Preprint Server for Health Sciences. Sep, 2020 | Pubmed ID: 32995823 Extreme Thrombocytosis is Associated with Critical Illness and Young Age, but Not Increased Thrombotic Risk, in Hospitalized Pediatric Patients Journal of Thrombosis and Haemostasis : JTH. Dec, 2020 | Pubmed ID: 32979018 Genetic Determinants of Increased Body Mass Index Mediate the Effect of Smoking on Increased Risk for Type 2 Diabetes but Not Coronary Artery Disease Human Molecular Genetics. Nov, 2020 | Pubmed ID: 32833022 Genetic Colocalization Atlas Points to Common Regulatory Sites and Genes for Hematopoietic Traits and Hematopoietic Contributions to Disease Phenotypes BMC Medical Genomics. Jun, 2020 | Pubmed ID: 32600345 Tropomyosin 1 Genetically Constrains in Vitro Hematopoiesis BMC Biology. May, 2020 | Pubmed ID: 32408895 Neonatal Platelet Count Trends During Inhaled Nitric Oxide Therapy British Journal of Haematology. Feb, 2020 | Pubmed ID: 31840227 The Autophagy-activating Kinase ULK1 Mediates Clearance of Free α-globin in β-thalassemia Science Translational Medicine. Aug, 2019 | Pubmed ID: 31434755 Nonspecific Inhibition of Erythropoiesis by Short Hairpin RNAs Blood. Jun, 2018 | Pubmed ID: 29728407 Utility and Limitations of Exome Sequencing in the Molecular Diagnosis of Pediatric Inherited Platelet Disorders American Journal of Hematology. Jan, 2018 | Pubmed ID: 28960434 FLI1 Level During Megakaryopoiesis Affects Thrombopoiesis and Platelet Biology Blood. Jun, 2017 | Pubmed ID: 28432223 Trim58 Degrades Dynein and Regulates Terminal Erythropoiesis Developmental Cell. Sep, 2014 | Pubmed ID: 25241935 Hemoglobin Variants: Biochemical Properties and Clinical Correlates Cold Spring Harbor Perspectives in Medicine. Mar, 2013 | Pubmed ID: 23388674 Integrated Protein Quality-control Pathways Regulate Free α-globin in Murine β-thalassemia Blood. May, 2012 | Pubmed ID: 22427201 Loss of the Epigenetic Tumor Suppressor SNF5 Leads to Cancer Without Genomic Instability Molecular and Cellular Biology. Oct, 2008 | Pubmed ID: 18710953 Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics Rong Qiu1, Chayanne Petit1, Christopher S. Thom1,2 1Division of Neonatology, Children’s Hospital of Philadelphia, 2Department of Pediatrics, University of Pennsylvania Perelman School of Medicine JoVE 66490 Biologie du développement
Author Spotlight: Advancing In Vitro Blood Cell Production with Single-Cell Multiomics and Functional Genomics Rong Qiu1, Chayanne Petit1, Christopher S. Thom1,2 1Division of Neonatology, Children’s Hospital of Philadelphia, 2Department of Pediatrics, University of Pennsylvania Perelman School of Medicine JoVE 66490 Biologie du développement