Dieter Egli Departments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center Columbia University Biography Publications Institution JoVE Articles Dieter Egli has not added a biography. If you are Dieter Egli and would like to personalize this page please email our Author Liaison for assistance. Publications Permanent Neonatal Diabetes-causing Insulin Mutations Have Dominant Negative Effects on Beta Cell Identity Molecular Metabolism. Jan, 2024 | Pubmed ID: 38237895 Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells Cell Reports. Jan, 2024 | Pubmed ID: 38194345 DNA Replication in Early Mammalian Embryos is Patterned, Predisposing Lamina-associated Regions to Fragility BioRxiv : the Preprint Server for Biology. Dec, 2023 | Pubmed ID: 38234839 Permanent Neonatal Diabetes-causing Insulin Mutations Have Dominant Negative Effects on Beta Cell Identity BioRxiv : the Preprint Server for Biology. Sep, 2023 | Pubmed ID: 37745320 Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells BioRxiv : the Preprint Server for Biology. Jun, 2023 | Pubmed ID: 37398435 Replication Stress in Mammalian Embryo Development, Differentiation, and Reprogramming Trends in Cell Biology. Oct, 2023 | Pubmed ID: 37202286 ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition Cells. Mar, 2023 | Pubmed ID: 36980244 Reduced Calcium Levels and Accumulation of Abnormal Insulin Granules in Stem Cell Models of HNF1A Deficiency Communications Biology. Aug, 2022 | Pubmed ID: 35918471 Replication Stress Impairs Chromosome Segregation and Preimplantation Development in Human Embryos Cell. Aug, 2022 | Pubmed ID: 35858625 Comprehensive Analysis of DNA Replication Timing Across 184 Cell Lines Suggests a Role for MCM10 in Replication Timing Regulation Human Molecular Genetics. Aug, 2022 | Pubmed ID: 35394024 Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes Frontiers in Endocrinology. 2021 | Pubmed ID: 34858326 Delayed DNA Replication in Haploid Human Embryonic Stem Cells Genome Research. Dec, 2021 | Pubmed ID: 34810218 The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem Cells Nature Communications. Nov, 2021 | Pubmed ID: 34799581 Heritable Human Genome Editing: Research Progress, Ethical Considerations, and Hurdles to Clinical Practice Cell. Mar, 2021 | Pubmed ID: 33740453 Bardet-Biedl Syndrome Proteins Regulate Intracellular Signaling and Neuronal Function in Patient-specific IPSC-derived Neurons The Journal of Clinical Investigation. Apr, 2021 | Pubmed ID: 33630762 Reduced Replication Fork Speed Promotes Pancreatic Endocrine Differentiation and Controls Graft Size JCI Insight. Mar, 2021 | Pubmed ID: 33529174 Allele-Specific Chromosome Removal After Cas9 Cleavage in Human Embryos Cell. Dec, 2020 | Pubmed ID: 33125898 How Safe Are Universal Pluripotent Stem Cells? Cell Stem Cell. Aug, 2020 | Pubmed ID: 32763183 Detection of Base Analogs Incorporated During DNA Replication by Nanopore Sequencing Nucleic Acids Research. Sep, 2020 | Pubmed ID: 32710620 Pluripotent Stem Cells with Low Differentiation Potential Contain Incompletely Reprogrammed DNA Replication The Journal of Cell Biology. Sep, 2020 | Pubmed ID: 32673399 Lessons Learned from Somatic Cell Nuclear Transfer International Journal of Molecular Sciences. Mar, 2020 | Pubmed ID: 32230814 Efficient SNP Editing in Haploid Human Pluripotent Stem Cells Journal of Assisted Reproduction and Genetics. Apr, 2020 | Pubmed ID: 32162131 How Safe Are Universal Pluripotent Stem Cells? Cell Stem Cell. Mar, 2020 | Pubmed ID: 32142661 GLP-1 Receptor Agonists Synergize with DYRK1A Inhibitors to Potentiate Functional Human β Cell Regeneration Science Translational Medicine. Feb, 2020 | Pubmed ID: 32051230 Physiological Consequences of Transient Hyperleptinemia During Discrete Developmental Periods on Body Weight in Mice Science Translational Medicine. Jan, 2020 | Pubmed ID: 31894105 Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1 Diabetes. Dec, 2019 | Pubmed ID: 31519700 Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells Cell Stem Cell. Sep, 2019 | Pubmed ID: 31491396 Stimulation of CRISPR-mediated Homology-directed Repair by an Engineered RAD18 Variant Nature Communications. Jul, 2019 | Pubmed ID: 31363085 Induction of α Cell-restricted Gc in Dedifferentiating β Cells Contributes to Stress-induced β-cell Dysfunction JCI Insight. May, 2019 | Pubmed ID: 31120862 Transgenic Substitution with Greater Amberjack Seriola Dumerili Fish Insulin 2 in NOD Mice Reduces Beta Cell Immunogenicity Scientific Reports. Mar, 2019 | Pubmed ID: 30899071 Ciliary Gene RPGRIP1L is Required for Hypothalamic Arcuate Neuron Development JCI Insight. Feb, 2019 | Pubmed ID: 30728336 NanoMod: a Computational Tool to Detect DNA Modifications Using Nanopore Long-read Sequencing Data BMC Genomics. Feb, 2019 | Pubmed ID: 30712508 Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells Cell Metabolism. Mar, 2019 | Pubmed ID: 30581122 β Cell Replacement After Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus Stem Cell Reports. Dec, 2018 | Pubmed ID: 30503261 Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells Current Protocols in Human Genetics. Oct, 2018 | Pubmed ID: 30192441 Inter-homologue Repair in Fertilized Human Eggs? Nature. 08, 2018 | Pubmed ID: 30089924 Identification and Analysis of Islet Antigen-Specific CD8 T Cells with T Cell Libraries Journal of Immunology (Baltimore, Md. : 1950). Sep, 2018 | Pubmed ID: 30082321 Compensating Human Subjects Providing Oocytes for Stem Cell Research: 9-year Experience and Outcomes Journal of Assisted Reproduction and Genetics. Jul, 2018 | Pubmed ID: 29872942 ILDR2 Has a Negligible Role in Hepatic Steatosis PloS One. 2018 | Pubmed ID: 29847571 Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells Transplantation. Aug, 2018 | Pubmed ID: 29781950 β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells Diabetes. Jan, 2018 | Pubmed ID: 28931519 Tying Genetic Stability to Cell Identity Cell Cycle (Georgetown, Tex.). Jun, 2017 | Pubmed ID: 28548589 Genomic Instability During Reprogramming by Nuclear Transfer is DNA Replication Dependent Nature Cell Biology. Apr, 2017 | Pubmed ID: 28263958 Genome Transfer Prevents Fragmentation and Restores Developmental Potential of Developmentally Compromised Postovulatory Aged Mouse Oocytes Stem Cell Reports. Mar, 2017 | Pubmed ID: 28242217 PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons Stem Cell Reports. Feb, 2017 | Pubmed ID: 28132887 Inconsistency in 'three-parent' IVF Study Reproductive Biomedicine Online. Mar, 2017 | Pubmed ID: 28038847 Deficiency in Prohormone Convertase PC1 Impairs Prohormone Processing in Prader-Willi Syndrome The Journal of Clinical Investigation. Jan, 2017 | Pubmed ID: 27941249 Induced Pluripotent Stem Cells (iPSC) Created from Skin Fibroblasts of Patients with Prader-Willi Syndrome (PWS) Retain the Molecular Signature of PWS Stem Cell Research. Nov, 2016 | Pubmed ID: 27789403 Identification and Propagation of Haploid Human Pluripotent Stem Cells Nature Protocols. Nov, 2016 | Pubmed ID: 27763625 Analysis of Chromosomal Aberrations and Recombination by Allelic Bias in RNA-Seq Nature Communications. Jul, 2016 | Pubmed ID: 27385103 Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells Current Protocols in Human Genetics. Jul, 2016 | Pubmed ID: 27367166 Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes Cell Stem Cell. Jun, 2016 | Pubmed ID: 27212703 Hypomorphism of Fto and Rpgrip1l Causes Obesity in Mice The Journal of Clinical Investigation. May, 2016 | Pubmed ID: 27064284 Derivation and Differentiation of Haploid Human Embryonic Stem Cells Nature. Apr, 2016 | Pubmed ID: 26982723 Attitudes Toward Prevention of MtDNA-related Diseases Through Oocyte Mitochondrial Replacement Therapy Human Reproduction (Oxford, England). May, 2016 | Pubmed ID: 26936885 Human Embryos Commonly Form Abnormal Nuclei During Development: a Mechanism of DNA Damage, Embryonic Aneuploidy, and Developmental Arrest Human Reproduction (Oxford, England). Feb, 2016 | Pubmed ID: 26621855 From Cloned Frogs to Patient Matched Stem Cells: Induced Pluripotency or Somatic Cell Nuclear Transfer? Current Opinion in Genetics & Development. Oct, 2015 | Pubmed ID: 26282611 Toward Beta Cell Replacement for Diabetes The EMBO Journal. Apr, 2015 | Pubmed ID: 25733347 Differentiation of Hypothalamic-like Neurons from Human Pluripotent Stem Cells The Journal of Clinical Investigation. Feb, 2015 | Pubmed ID: 25555215 Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes? EBioMedicine. Dec, 2014 | Pubmed ID: 26137512 Comparable Frequencies of Coding Mutations and Loss of Imprinting in Human Pluripotent Cells Derived by Nuclear Transfer and Defined Factors Cell Stem Cell. Nov, 2014 | Pubmed ID: 25517467 FOXO1 Inhibition Yields Functional Insulin-producing Cells in Human Gut Organoid Cultures Nature Communications. 2014 | Pubmed ID: 24979718 Gene Therapy in Patient-specific Stem Cell Lines and a Preclinical Model of Retinitis Pigmentosa with Membrane Frizzled-related Protein Defects Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2014 | Pubmed ID: 24895994 Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice Cell Metabolism. May, 2014 | Pubmed ID: 24807221 Human Oocytes Reprogram Adult Somatic Nuclei of a Type 1 Diabetic to Diploid Pluripotent Stem Cells Nature. Jun, 2014 | Pubmed ID: 24776804 Hyperphagia: Current Concepts and Future Directions Proceedings of the 2nd International Conference on Hyperphagia Obesity (Silver Spring, Md.). Feb, 2014 | Pubmed ID: 24574081 Validation of Genome-wide Association Study (GWAS)-identified Disease Risk Alleles with Patient-specific Stem Cell Lines Human Molecular Genetics. Jul, 2014 | Pubmed ID: 24497574 β-cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome Diabetes. Mar, 2014 | Pubmed ID: 24227685 Harnessing the Stem Cell Potential: the Path to Prevent Mitochondrial Disease Nature Medicine. Dec, 2013 | Pubmed ID: 24309656 Mouse BAZ1A (ACF1) is Dispensable for Double-strand Break Repair but is Essential for Averting Improper Gene Expression During Spermatogenesis PLoS Genetics. Nov, 2013 | Pubmed ID: 24244200 Connecting the Cell Cycle with Cellular Identity Cellular Reprogramming. Oct, 2013 | Pubmed ID: 24073943 IPSC-derived β Cells Model Diabetes Due to Glucokinase Deficiency The Journal of Clinical Investigation. Jul, 2013 | Pubmed ID: 23778137 Tying Replication to Cell Identity Nature Reviews. Molecular Cell Biology. Jun, 2013 | Pubmed ID: 23698578 Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting PloS One. 2013 | Pubmed ID: 23555815 Nuclear Genome Transfer in Human Oocytes Eliminates Mitochondrial DNA Variants Nature. Jan, 2013 | Pubmed ID: 23254936 Mouse Ooplasm Confers Context-specific Reprogramming Capacity Nature Genetics. Sep, 2012 | Pubmed ID: 22902786 长期安全和疗效的人类诱导多功能干细胞 (iPS) 移植在临床前期模型中视网膜色素变性。 Molecular Medicine (Cambridge, Mass.). Aug, 2012 | Pubmed ID: 22895806 BRCA1 肿瘤抑制取决于 BRCT 磷蛋白具有约束力,但不是及 E3 连接酶活性。 Science (New York, N.Y.). Oct, 2011 | Pubmed ID: 22034435 用途并不蛋者招募中缺席的补偿。 Cell Stem Cell. Oct, 2011 | Pubmed ID: 21982228 人卵母细胞重新编程体细胞胚胎状态。 Nature. Oct, 2011 | Pubmed ID: 21979046 小时后核转移到鼠标,但不是人类受精卵内重新编程。 Nature Communications. 2011 | Pubmed ID: 21971503 纽约干细胞基础: 第五次年度平移的干细胞研究会议。 Annals of the New York Academy of Sciences. May, 2011 | Pubmed ID: 21615750 收件人细胞核因子所需的细胞核重新编程。 Development (Cambridge, England). Jun, 2010 | Pubmed ID: 20463036 平移的干细胞研究突破。 Annals of the New York Academy of Sciences. Mar, 2010 | Pubmed ID: 20233361 金属反应转录因子 (MTF-1) 在果蝇中表达改善与氧化应激和金属毒性相关的寿命减少。 Neurobiology of Aging. Jul, 2010 | Pubmed ID: 18775584 一种小分子抑制剂 Tgf-β 信号替换 Sox2 在诱导 Nanog 重新编程。 Cell Stem Cell. Nov, 2009 | Pubmed ID: 19818703 染色体转移到小鼠卵裂球后重新编程。 Current Biology : CB. Aug, 2009 | Pubmed ID: 19682906 数字 RNA Allelotyping 揭示了人体组织特异性和特异性基因的表达。 Nature Methods. Aug, 2009 | Pubmed ID: 19620972 有针对性的亚硫酸测序揭示了 DNA 甲基化与核重编程相关的变化。 Nature Biotechnology. Apr, 2009 | Pubmed ID: 19330000 时机选择的内在细胞大规模分离提高人类胚胎干细胞衍生的效率,并允许同级细胞系的一代。 Cell Stem Cell. Feb, 2009 | Pubmed ID: 19200798 Dumpy-30 家庭成员作为男性生育力和互动伙伴金属反应的转录因子 1 (MTF-1) 的果蝇的决定因素。 BMC Developmental Biology. 2008 | Pubmed ID: 18588663 调解员的重编程: 转录因子和通过有丝分裂的过渡。 Nature Reviews. Molecular Cell Biology. Jul, 2008 | Pubmed ID: 18568039 非洲足联 1 是果蝇发展的必要条件和所涉及的表观遗传记忆保持。 Developmental Biology. Nov, 2007 | Pubmed ID: 17916346 发展到有丝分裂的小鼠受精卵的染色体转移后重新编程。 Nature. Jun, 2007 | Pubmed ID: 17554301 在果蝇中通过导入、 存储和避税行为的复杂相互作用的铜动态平衡。 The EMBO Journal. Feb, 2007 | Pubmed ID: 17290228 转基因果蝇体内建造。 Genetics. Apr, 2007 | Pubmed ID: 17179096 转录过程对重金属胁迫的响应在果蝇中揭示了赋予耐锌新锌转运蛋白。 Nucleic Acids Research. 2006 | Pubmed ID: 16973896 果蝇金属硫蛋白家族的四名成员表现出不同尚未重叠在重金属稳态和解毒的作用。 Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jun, 2006 | Pubmed ID: 16716195 家庭的挖空效果的所有四个果蝇金属硫蛋白揭示了铜稳态和戒毒中心作用。 Molecular and Cellular Biology. Mar, 2006 | Pubmed ID: 16508004 金属反应的转录因子 (MTF-1) 处理这两个极端,铜负载和铜的饥饿,通过激活不同的基因。 Genes & Development. Apr, 2005 | Pubmed ID: 15833915 重金属和金属反应的转录因子 (MTF-1) 强调在果蝇和哺乳动物细胞的反应: 功能比较。 Biological Chemistry. Jul, 2004 | Pubmed ID: 15318808 一种有效的方法,要生成的目标 DNA 双链的染色体重排黑腹果蝇中的分页符。 Genome Research. Jul, 2004 | Pubmed ID: 15197166 布卢姆综合征基因产品和染色质大会因子 1 的最大亚基之间的物理和功能互动。 Molecular and Cellular Biology. Jun, 2004 | Pubmed ID: 15143166 挖空 '金属反应的转录因子' 的 MTF-1 果蝇的同源重组中揭示了在重金属稳态的中心作用。 The EMBO Journal. Jan, 2003 | Pubmed ID: 12505988 Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells Ines Cherkaoui1, Qian Du2, Dieter Egli2, Shivani Misra1,3, Guy A. Rutter1,4,5 1Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Cell Biology and Functional Genomics, 2Departments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, 3Department of Diabetes, Imperial College Healthcare NHS Trust, 4Faculté de Médicine, Université de Montréal, 5Lee Kong Chian Imperial Medical School, Nanyang Technological University JoVE 65530 Biologie 小鼠卵母细胞的细胞核移植到 Dieter Egli1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 116 Biologie
Author Spotlight: Advancements and Challenges in β-Cells Differentiation from Pluripotent Stem Cells Ines Cherkaoui1, Qian Du2, Dieter Egli2, Shivani Misra1,3, Guy A. Rutter1,4,5 1Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Cell Biology and Functional Genomics, 2Departments of Pediatrics, Naomi Berrie Diabetes Center, Obstetrics and Gynecology, Columbia Stem Cell Initiative, Columbia University Irving Medical Center, Columbia University, 3Department of Diabetes, Imperial College Healthcare NHS Trust, 4Faculté de Médicine, Université de Montréal, 5Lee Kong Chian Imperial Medical School, Nanyang Technological University JoVE 65530 Biologie
小鼠卵母细胞的细胞核移植到 Dieter Egli1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 116 Biologie