Frank Wuest Department of Oncology University of Alberta Biography Publications Institution JoVE Articles Frank Wuest has not added a biography. If you are Frank Wuest and would like to personalize this page please email our Author Liaison for assistance. Publications Radiosynthesis and Biological Evaluation of [F]Triacoxib: A New Radiotracer for PET Imaging of COX-2 Molecular Pharmaceutics. Jan, 2020 | Pubmed ID: 31816246 Inhibition of Autotaxin with GLPG1690 Increases the Efficacy of Radiotherapy and Chemotherapy in a Mouse Model of Breast Cancer Molecular Cancer Therapeutics. Jan, 2020 | Pubmed ID: 31548293 Radiometal-Containing Aryl Diazonium Salts for Chemoselective Bioconjugation of Tyrosine Residues ACS Omega. Dec, 2019 | Pubmed ID: 31891090 Comparison of Scandium-44 g with Other PET Radionuclides in Pre-clinical PET Phantom Imaging EJNMMI Physics. Dec, 2019 | Pubmed ID: 31832809 Repeated Fractions of X-Radiation to the Breast Fat Pads of Mice Augment Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle Cancers. Nov, 2019 | Pubmed ID: 31752313 Effect of Hypoxia on Human Equilibrative Nucleoside Transporters HENT1 and HENT2 in Breast Cancer FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2019 | Pubmed ID: 31601121 Targeting Phosphatidylserine for Radionuclide-based Molecular Imaging of Apoptosis Apoptosis : an International Journal on Programmed Cell Death. 04, 2019 | Pubmed ID: 30684144 Sulfo-click Chemistry with F-labeled Thio Acids Chemical Communications (Cambridge, England). Jan, 2019 | Pubmed ID: 30633279 Expression and Function of Hexose Transporters GLUT1, GLUT2, and GLUT5 in Breast Cancer-effects of Hypoxia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 09, 2018 | Pubmed ID: 29913554 Impact of Structural Alterations on the Radiopharmacological Profile of F-labeled Pyrimidines As Cyclooxygenase-2 (COX-2) Imaging Agents Nuclear Medicine and Biology. Jul - Aug, 2018 | Pubmed ID: 29800798 Molecular Imaging of Platelet-derived Growth Factor Receptor-alpha (PDGFRα) in Papillary Thyroid Cancer Using Immuno-PET Nuclear Medicine and Biology. 03, 2018 | Pubmed ID: 29367096 F-Radiolabeling and In Vivo Analysis of SiFA-Derivatized Polymeric Core-Shell Nanoparticles Bioconjugate Chemistry. 01, 2018 | Pubmed ID: 29202229 Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice Molecular Pharmacology. 02, 2018 | Pubmed ID: 29142019 Targeting Prostate-Specific Membrane Antigen (PSMA) with F-18-Labeled Compounds: the Influence of Prosthetic Groups on Tumor Uptake and Clearance Profile Molecular Imaging and Biology. 12, 2017 | Pubmed ID: 28639122 Implications for Breast Cancer Treatment from Increased Autotaxin Production in Adipose Tissue After Radiotherapy FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 09, 2017 | Pubmed ID: 28539367 In Situ Click Chemistry Generation of Cyclooxygenase-2 Inhibitors Nature Communications. 02, 2017 | Pubmed ID: 28232747 Fluorescent Hexose Conjugates Establish Stringent Stereochemical Requirement by GLUT5 for Recognition and Transport of Monosaccharides ACS Chemical Biology. 04, 2017 | Pubmed ID: 28205432 Targeting Phosphatidylserine with a Cu-Labeled Peptide for Molecular Imaging of Apoptosis Molecular Pharmaceutics. 10, 2016 | Pubmed ID: 27608290 Structure-activity Relationship of Novel Series of 1,5-disubstituted Tetrazoles As Cyclooxygenase-2 Inhibitors: Design, Synthesis, Bioassay Screening and Molecular Docking Studies Bioorganic & Medicinal Chemistry Letters. 10, 2016 | Pubmed ID: 27567369 Synthesis and Pre-clinical Evaluation of an (18)F-labeled Single-chain Antibody Fragment for PET Imaging of Epithelial Ovarian Cancer American Journal of Nuclear Medicine and Molecular Imaging. 2016 | Pubmed ID: 27508105 Pyrimidine-based Fluorescent COX-2 Inhibitors: Synthesis and Biological Evaluation Organic & Biomolecular Chemistry. Jul, 2016 | Pubmed ID: 27383140 Automated Synthesis of [(18)F]DCFPyL Via Direct Radiofluorination and Validation in Preclinical Prostate Cancer Models EJNMMI Research. Dec, 2016 | Pubmed ID: 27142881 PET Imaging of Cyclooxygenase-2 (COX-2) in a Pre-clinical Colorectal Cancer Model EJNMMI Research. Dec, 2016 | Pubmed ID: 27112768 Metabolically Stabilized (68)Ga-NOTA-Bombesin for PET Imaging of Prostate Cancer and Influence of Protease Inhibitor Phosphoramidon Molecular Pharmaceutics. Apr, 2016 | Pubmed ID: 26973098 Design and Synthesis of [(125)I]Pyricoxib: A Novel (125)I-labeled Cyclooxygenase-2 (COX-2) Inhibitors Bioorganic & Medicinal Chemistry Letters. Mar, 2016 | Pubmed ID: 26898334 Preclinical 89Zr Immuno-PET of High-Grade Serous Ovarian Cancer and Lymph Node Metastasis Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2016 | Pubmed ID: 26837339 18F-Labeled Wild-type Annexin V: Comparison of Random and Site-selective Radiolabeling Methods Amino Acids. Jan, 2016 | Pubmed ID: 26255286 Synthesis and Structural Identification of Fluorine-18 Labeled Parathyroid Hormone Journal of Labelled Compounds & Radiopharmaceuticals. Sep-Oct, 2015 | Pubmed ID: 26356136 Design, Synthesis, and Evaluation of an (18)F-Labeled Radiotracer Based on Celecoxib-NBD for Positron Emission Tomography (PET) Imaging of Cyclooxygenase-2 (COX-2) ChemMedChem. Oct, 2015 | Pubmed ID: 26287271 Targeting Lysyl Oxidase for Molecular Imaging in Breast Cancer Breast Cancer Research : BCR. Aug, 2015 | Pubmed ID: 26265048 Radiopharmacological Evaluation of (18)F-labeled Phosphatidylserine-binding Peptides for Molecular Imaging of Apoptosis Nuclear Medicine and Biology. Nov, 2015 | Pubmed ID: 26205076 Diaryl-Substituted (Dihydro)pyrrolo[3,2,1-hi]indoles, a Class of Potent COX-2 Inhibitors with Tricyclic Core Structure The Journal of Organic Chemistry. Jun, 2015 | Pubmed ID: 25909690 Sonogashira Cross-coupling Reaction with 4-[18F]fluoroiodobenzene for Rapid 18F-labelling of Peptides Chemical Communications (Cambridge, England). Mar, 2015 | Pubmed ID: 25650065 Erratum: Automated Synthesis and Dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a Radiotracer for Imaging of GLUT5 in Breast Cancer American Journal of Nuclear Medicine and Molecular Imaging. 2015 | Pubmed ID: 25625031 Rerouting the Metabolic Pathway of (18)F-labeled Peptides: the Influence of Prosthetic Groups Bioconjugate Chemistry. Feb, 2015 | Pubmed ID: 25572982 Immuno-PET of Epithelial Ovarian Cancer: Harnessing the Potential of CA125 for Non-invasive Imaging EJNMMI Research. Dec, 2014 | Pubmed ID: 26116121 18F-Labeled Peptides: The Future Is Bright Molecules (Basel, Switzerland). Dec, 2014 | Pubmed ID: 25493636 Improved Soluble Expression of a Single-chain Antibody Fragment in E. Coli for Targeting CA125 in Epithelial Ovarian Cancer Protein Expression and Purification. Oct, 2014 | Pubmed ID: 25079010 Synthesis and Evaluation of 2-amino-5-(4-[(18)F]fluorophenyl)pent-4-ynoic Acid ([(18)F]FPhPA): a Novel (18)F-labeled Amino Acid for Oncologic PET Imaging Nuclear Medicine and Biology. Sep, 2014 | Pubmed ID: 24993371 Automated Synthesis and Dosimetry of 6-deoxy-6-[(18)F]fluoro-D-fructose (6-[(18)F]FDF): a Radiotracer for Imaging of GLUT5 in Breast Cancer American Journal of Nuclear Medicine and Molecular Imaging. 2014 | Pubmed ID: 24795839 Do Nitric Oxide-releasing Drugs Offer a Potentially New Paradigm for the Management of Cardiovascular Risks in Diabetes? Expert Review of Cardiovascular Therapy. May, 2014 | Pubmed ID: 24725228 Fluorophore-labeled Cyclooxygenase-2 Inhibitors for the Imaging of Cyclooxygenase-2 Overexpression in Cancer: Synthesis and Biological Studies ChemMedChem. Jan, 2014 | Pubmed ID: 24376205 Positron Emission Tomography Radiotracers for Imaging Hypoxia Journal of Labelled Compounds & Radiopharmaceuticals. Mar-Apr, 2013 | Pubmed ID: 24285331 Synthesis of Three 18F-labelled Cyclooxygenase-2 (COX-2) Inhibitors Based on a Pyrimidine Scaffold Organic & Biomolecular Chemistry. Dec, 2013 | Pubmed ID: 24145766 Radiotracers for Molecular Imaging of Cyclooxygenase-2 (COX-2) Enzyme Current Medicinal Chemistry. 2013 | Pubmed ID: 24059237 Application of [18F]FDG in Radiolabeling Reactions Using Microfluidic Technology Lab on a Chip. Nov, 2013 | Pubmed ID: 24056916 Synthesis and Radiopharmacological Evaluation of a High-affinity and Metabolically Stabilized 18F-labeled Bombesin Analogue for Molecular Imaging of Gastrin-releasing Peptide Receptor-expressing Prostate Cancer Nuclear Medicine and Biology. Nov, 2013 | Pubmed ID: 23969085 Synthesis, Characterisation and Evaluation of a Novel Copper-64 Complex with Selective Uptake in EMT-6 Cells Under Hypoxic Conditions Dalton Transactions (Cambridge, England : 2003). Jul, 2013 | Pubmed ID: 23838751 1,4-Diaryl-substituted Triazoles As Cyclooxygenase-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modeling Studies Bioorganic & Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23706267 Synthesis and Evaluation of an 18F-labelled Norbornene Derivative for Copper-free Click Chemistry Reactions Organic & Biomolecular Chemistry. Jun, 2013 | Pubmed ID: 23640655 Fully Automated Synthesis of 4-[18F]fluorobenzylamine Based on Borohydride/NiCl2 Reduction Nuclear Medicine and Biology. Apr, 2013 | Pubmed ID: 23306136 Hybrid Fluorescent Conjugates of COX-2 Inhibitors: Search for a COX-2 Isozyme Imaging Cancer Biomarker Bioorganic & Medicinal Chemistry Letters. Jan, 2013 | Pubmed ID: 23200247 Comparative Functional Evaluation of Immunocompetent Mouse Breast Cancer Models Established from PyMT-tumors Using Small Animal PET with [(18)F]FDG and [(18)F]FLT American Journal of Nuclear Medicine and Molecular Imaging. 2012 | Pubmed ID: 23133804 Fluorine- and Rhenium-containing Geldanamycin Derivatives As Leads for the Development of Molecular Probes for Imaging Hsp90 Organic & Biomolecular Chemistry. Sep, 2012 | Pubmed ID: 22825378 Synthesis and Evaluation of Fluorobenzoylated Di- and Tripeptides As Inhibitors of Cyclooxygenase-2 (COX-2) Bioorganic & Medicinal Chemistry. Apr, 2012 | Pubmed ID: 22386983 Microfluidic Technology: an Economical and Versatile Approach for the Synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) Bioorganic & Medicinal Chemistry Letters. Mar, 2012 | Pubmed ID: 22342141 Novel 5-substituted 1H-tetrazoles As Cyclooxygenase-2 (COX-2) Inhibitors Bioorganic & Medicinal Chemistry Letters. Mar, 2012 | Pubmed ID: 22341941 Radiotracers Based on Technetium-94m Current Radiopharmaceuticals. Apr, 2011 | Pubmed ID: 22191648 Copper-free Click Chemistry with the Short-lived Positron Emitter Fluorine-18 Organic & Biomolecular Chemistry. Nov, 2011 | Pubmed ID: 21938294 Cyclooxygenase-2 Inhibitors: a Literature and Patent Review (2009 - 2010) Expert Opinion on Therapeutic Patents. Sep, 2011 | Pubmed ID: 21714592 Radiolabeling of Phosphatidylserine-binding Peptides with Prosthetic Groups N-[6-(4-[18F]fluorobenzylidene)aminooxyhexyl]maleimide ([18F]FBAM) and N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine. Sep, 2011 | Pubmed ID: 21571539 Radiopharmacological Evaluation of 6-deoxy-6-[18F]fluoro-D-fructose As a Radiotracer for PET Imaging of GLUT5 in Breast Cancer Nuclear Medicine and Biology. May, 2011 | Pubmed ID: 21531283 Synthesis and Evaluation of 1,5-diaryl-substituted Tetrazoles As Novel Selective Cyclooxygenase-2 (COX-2) Inhibitors Bioorganic & Medicinal Chemistry Letters. Mar, 2011 | Pubmed ID: 21316237 Synthesis of Hypoxia Imaging Agent 1-(5-deoxy-5-fluoro-α-D-arabinofuranosyl)-2-nitroimidazole Using Microfluidic Technology Nuclear Medicine and Biology. Feb, 2011 | Pubmed ID: 21315279 Synthesis and Application of 4-[(18)F]fluorobenzylamine: A Versatile Building Block for the Preparation of PET Radiotracers Organic & Biomolecular Chemistry. Oct, 2010 | Pubmed ID: 20740244 Iodine-124: a Promising Positron Emitter for Organic PET Chemistry Molecules (Basel, Switzerland). Apr, 2010 | Pubmed ID: 20428073 [Not Available] Journal of Oncology. 2009 | Pubmed ID: 19551155 Synthesis and Cyclooxygenase Inhibition of Various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl Derivatives Bioorganic & Medicinal Chemistry. Feb, 2009 | Pubmed ID: 19157881 18 F-Rotulagem de Radiotracers Funcionalizado com um Acceptor de Fluoreto de Silício (SiFA) para Tomografia de Emissão de Pósitrons David Connolly*1, Justin J. Bailey*1, Harun Ilhan2,3, Peter Bartenstein2,3, Carmen Wängler4, Björn Wängler5, Melinda Wuest1, Frank Wuest1, Ralf Schirrmacher1 1Department of Oncology, University of Alberta, 2Department of Nuclear Medicine, University Hospital of Munich, 3ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich, 4Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, 5Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University JoVE 60623 Chimie
18 F-Rotulagem de Radiotracers Funcionalizado com um Acceptor de Fluoreto de Silício (SiFA) para Tomografia de Emissão de Pósitrons David Connolly*1, Justin J. Bailey*1, Harun Ilhan2,3, Peter Bartenstein2,3, Carmen Wängler4, Björn Wängler5, Melinda Wuest1, Frank Wuest1, Ralf Schirrmacher1 1Department of Oncology, University of Alberta, 2Department of Nuclear Medicine, University Hospital of Munich, 3ENETS Centre of Excellence, Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System, LMU Munich, 4Biomedical Chemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University, 5Molecular Imaging and Radiochemistry, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim of Heidelberg University JoVE 60623 Chimie