J. Paul Taylor Developmental Neurobiology St. Jude Children’s Research Hospital Biography Publications Institution JoVE Articles J. Paul Taylor has not added a biography. If you are J. Paul Taylor and would like to personalize this page please email our Author Liaison for assistance. Publications Archetypal and New Families With Alexander Disease and Novel Mutations in GFAP Archives of Neurology. Feb, 2012 | Pubmed ID: 21987397 Mutational Analysis of the VCP Gene in Parkinson's Disease Neurobiology of Aging. Jan, 2012 | Pubmed ID: 21920633 A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B is Expressed Exclusively in Mature Striated Muscle Cells PloS One. 2011 | Pubmed ID: 22174917 A Drosophila Model of FUS-related Neurodegeneration Reveals Genetic Interaction Between FUS and TDP-43 Human Molecular Genetics. Jul, 2011 | Pubmed ID: 21487023 Histone Deacetylases Suppress CGG Repeat-induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome PLoS Genetics. 2010 | Pubmed ID: 21170301 Exome Sequencing Reveals VCP Mutations As a Cause of Familial ALS Neuron. Dec, 2010 | Pubmed ID: 21145000 Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy Neuron. Sep, 2010 | Pubmed ID: 20869592 TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2010 | Pubmed ID: 20519548 Disease-causing Mutations in Parkin Impair Mitochondrial Ubiquitination, Aggregation, and HDAC6-dependent Mitophagy The Journal of Cell Biology. May, 2010 | Pubmed ID: 20457763 B2 Attenuates Polyglutamine-expanded Androgen Receptor Toxicity in Cell and Fly Models of Spinal and Bulbar Muscular Atrophy Journal of Neuroscience Research. Aug, 2010 | Pubmed ID: 20336775 Flightless Flies: Drosophila Models of Neuromuscular Disease Annals of the New York Academy of Sciences. Jan, 2010 | Pubmed ID: 20329357 Repeat Expansion Disease: Progress and Puzzles in Disease Pathogenesis Nature Reviews. Genetics. Apr, 2010 | Pubmed ID: 20177426 Transgenic Mice Expressing Mutant Forms VCP/p97 Recapitulate the Full Spectrum of IBMPFD Including Degeneration in Muscle, Brain and Bone Human Molecular Genetics. May, 2010 | Pubmed ID: 20147319 VCP/p97 is Essential for Maturation of Ubiquitin-containing Autophagosomes and This Function is Impaired by Mutations That Cause IBMPFD Autophagy. Feb, 2010 | Pubmed ID: 20104022 Dynein Light Chain 1 is Required for Autophagy, Protein Clearance, and Cell Death in Drosophila Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20080745 HDAC6 Controls Autophagosome Maturation Essential for Ubiquitin-selective Quality-control Autophagy The EMBO Journal. Mar, 2010 | Pubmed ID: 20075865 Disease Mutations in Rab7 Result in Unregulated Nucleotide Exchange and Inappropriate Activation Human Molecular Genetics. Mar, 2010 | Pubmed ID: 20028791 Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery Journal of Proteome Research. Feb, 2010 | Pubmed ID: 20020773 Overexpression of IGF-1 in Muscle Attenuates Disease in a Mouse Model of Spinal and Bulbar Muscular Atrophy Neuron. Aug, 2009 | Pubmed ID: 19679072 FOXO3a is Broadly Neuroprotective in Vitro and in Vivo Against Insults Implicated in Motor Neuron Diseases The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2009 | Pubmed ID: 19553463 Sarcoplasmic Redistribution of Nuclear TDP-43 in Inclusion Body Myositis Muscle & Nerve. Jul, 2009 | Pubmed ID: 19533646 Polyglutamine-expanded Androgen Receptor Truncation Fragments Activate a Bax-dependent Apoptotic Cascade Mediated by DP5/Hrk The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2009 | Pubmed ID: 19228953 Selective Accumulation of Aggregation-prone Proteasome Substrates in Response to Proteotoxic Stress Molecular and Cellular Biology. Apr, 2009 | Pubmed ID: 19158272 Autophagy and the Ubiquitin-proteasome System: Collaborators in Neuroprotection Biochimica Et Biophysica Acta. Dec, 2008 | Pubmed ID: 18930136 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes Autophagy. Feb, 2008 | Pubmed ID: 18188003 The Role of Autophagy in Age-related Neurodegeneration Neuro-Signals. 2008 | Pubmed ID: 18097162 HDAC6 at the Intersection of Autophagy, the Ubiquitin-proteasome System and Neurodegeneration Autophagy. Nov-Dec, 2007 | Pubmed ID: 17912024 HDAC6 Rescues Neurodegeneration and Provides an Essential Link Between Autophagy and the UPS Nature. Jun, 2007 | Pubmed ID: 17568747 Safety, Tolerability, and Pharmacokinetics of High-dose Idebenone in Patients with Friedreich Ataxia Archives of Neurology. Jun, 2007 | Pubmed ID: 17562928 Valosin-containing Protein and the Pathogenesis of Frontotemporal Dementia Associated with Inclusion Body Myopathy Acta Neuropathologica. Jul, 2007 | Pubmed ID: 17457594 TDP-43 in the Ubiquitin Pathology of Frontotemporal Dementia with VCP Gene Mutations Journal of Neuropathology and Experimental Neurology. Feb, 2007 | Pubmed ID: 17279000 Hsp70 Dynamics in Vivo: Effect of Heat Shock and Protein Aggregation Journal of Cell Science. Oct, 2004 | Pubmed ID: 15367583 A Screen for Drugs That Protect Against the Cytotoxicity of Polyglutamine-expanded Androgen Receptor Human Molecular Genetics. Feb, 2004 | Pubmed ID: 14709594 Valproic Acid Increases SMN Levels in Spinal Muscular Atrophy Patient Cells Annals of Neurology. Nov, 2003 | Pubmed ID: 14595654 Aberrant Histone Acetylation, Altered Transcription, and Retinal Degeneration in a Drosophila Model of Polyglutamine Disease Are Rescued by CREB-binding Protein Genes & Development. Jun, 2003 | Pubmed ID: 12815067 Polyglutamines Placed into Context Neuron. Jun, 2003 | Pubmed ID: 12797953 Aggresomes Protect Cells by Enhancing the Degradation of Toxic Polyglutamine-containing Protein Human Molecular Genetics. Apr, 2003 | Pubmed ID: 12651870 Hemolytic Anemia Presenting As Idiopathic Intracranial Hypertension Neurology. Sep, 2002 | Pubmed ID: 12297596 Altered Acetylation in Polyglutamine Disease: an Opportunity for Therapeutic Intervention? Trends in Molecular Medicine. May, 2002 | Pubmed ID: 12067622 Toxic Proteins in Neurodegenerative Disease Science (New York, N.Y.). Jun, 2002 | Pubmed ID: 12065827 Rescue of Polyglutamine-mediated Cytotoxicity by Double-stranded RNA-mediated RNA Interference Human Molecular Genetics. Jan, 2002 | Pubmed ID: 11809726 Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction Rebecca Smith1, J. Paul Taylor1 1Developmental Neurobiology, St. Jude Children’s Research Hospital JoVE 2676 Neurosciences
Dissection and Imaging of Active Zones in the Drosophila Neuromuscular Junction Rebecca Smith1, J. Paul Taylor1 1Developmental Neurobiology, St. Jude Children’s Research Hospital JoVE 2676 Neurosciences