Lawrence E. Heisler Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Lawrence E. Heisler has not added a biography. If you are Lawrence E. Heisler and would like to personalize this page please email our Author Liaison for assistance. Publications The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell. May, 2018 | Pubmed ID: 29681457 Mitochondrial Mutations Drive Prostate Cancer Aggression Nature Communications. 09, 2017 | Pubmed ID: 28939825 Genomic Hallmarks of Localized, Non-indolent Prostate Cancer Nature. 01, 2017 | Pubmed ID: 28068672 Germline BRCA2 Mutations Drive Prostate Cancers with Distinct Evolutionary Trajectories Nature Communications. Jan, 2017 | Pubmed ID: 28067867 A Comprehensive Assessment of Somatic Mutation Detection in Cancer Using Whole-genome Sequencing Nature Communications. Dec, 2015 | Pubmed ID: 26647970 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 CHIP-MYTH: a Novel Interactive Proteomics Method for the Assessment of Agonist-dependent Interactions of the Human β₂-adrenergic Receptor Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24561123 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Effects of the Paf1 Complex and Histone Modifications on SnoRNA 3'-end Formation Reveal Broad and Locus-specific Regulation Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23109428 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 Multiple Means to the Same End: the Genetic Basis of Acquired Stress Resistance in Yeast PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 Compound Prioritization Methods Increase Rates of Chemical Probe Discovery in Model Organisms Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 Dosage Suppression Genetic Interaction Networks Enhance Functional Wiring Diagrams of the Cell Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 A Comprehensive Platform for Highly Multiplexed Mammalian Functional Genetic Screens BMC Genomics. 2011 | Pubmed ID: 21548937 Highly-multiplexed Barcode Sequencing: an Efficient Method for Parallel Analysis of Pooled Samples Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 Genotype to Phenotype: a Complex Problem Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 A Comparative Analysis of DNA Barcode Microarray Feature Size BMC Genomics. 2009 | Pubmed ID: 19825181 Quantitative Phenotyping Via Deep Barcode Sequencing Genome Research. Oct, 2009 | Pubmed ID: 19622793 Chemical-genetic Profiling of Imidazo[1,2-a]pyridines and -pyrimidines Reveals Target Pathways Conserved Between Yeast and Human Cells PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 Off-target Effects of Psychoactive Drugs Revealed by Genome-wide Assays in Yeast PLoS Genetics. 2008 | Pubmed ID: 18688276 Yeast Barcoders: a Chemogenomic Application of a Universal Donor-strain Collection Carrying Bar-code Identifiers Nature Methods. Aug, 2008 | Pubmed ID: 18622398 Genomic DNA Functions As a Universal External Standard in Quantitative Real-time PCR Nucleic Acids Research. 2006 | Pubmed ID: 16840529 CpG Island Microarray Probe Sequences Derived from a Physical Library Are Representative of CpG Islands Annotated on the Human Genome Nucleic Acids Research. 2005 | Pubmed ID: 15911630 Competitive Genomic Screens of Barcoded Yeast Libraries Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biologie
Competitive Genomic Screens of Barcoded Yeast Libraries Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biologie