Robert P. Mecham

Publications

• Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency
  Frontiers in Cardiovascular Medicine. 2021  |   Pubmed ID: 34790711
• Deletion of Type VIII Collagen Reduces Blood Pressure, Increases Carotid Artery Functional Distensibility and Promotes Elastin Deposition
  Matrix Biology Plus. Dec, 2021  |   Pubmed ID: 34693248
• Vascular Smooth Muscle Cell Subpopulations and Neointimal Formation in Mouse Models of Elastin Insufficiency
  Arteriosclerosis, Thrombosis, and Vascular Biology. 12, 2021  |   Pubmed ID: 34587758
• Tissue-specific Smooth Muscle Cell Subtypes Identified by Transcriptional Profiling
  The International Journal of Biochemistry & Cell Biology. 10, 2021  |   Pubmed ID: 34411694
• JNK2 Gene Silencing for Elastic Matrix Regenerative Repair
  Tissue Engineering. Part A. Aug, 2021  |   Pubmed ID: 34409851
• Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency
  Function (Oxford, England). 2021  |   Pubmed ID: 34223172
• SVEP1 is a Human Coronary Artery Disease Locus That Promotes Atherosclerosis
  Science Translational Medicine. 03, 2021  |   Pubmed ID: 33762433
• Complex Consequences of Cantu Syndrome SUR2 Variant R1154Q in Genetically Modified Mice
  JCI Insight. 03, 2021  |   Pubmed ID: 33529173
• RNA Vaccines for COVID-19: 5 Things Every Cardiologist Should Know
  JACC. Basic to Translational Science. Dec, 2020  |   Pubmed ID: 33251385
• A Matricellular Protein Fibulin-4 is Essential for the Activation of Lysyl Oxidase
  Science Advances. Nov, 2020  |   Pubmed ID: 33239290
• Whole Exome Sequencing in Patients with Williams-Beuren Syndrome Followed by Disease Modeling in Mice Points to Four Novel Pathways That May Modify Stenosis Risk
  Human Molecular Genetics. May, 2020  |   Pubmed ID: 32412588
• Identification of the Growth Factor-binding Sequence in the Extracellular Matrix Protein MAGP-1
  The Journal of Biological Chemistry. 02, 2020  |   Pubmed ID: 31988245
• Elastic Fiber Ultrastructure and Assembly
  Matrix Biology : Journal of the International Society for Matrix Biology. 11, 2019  |   Pubmed ID: 31669522
• Sodium-activated Potassium Channels Moderate Excitability in Vascular Smooth Muscle
  The Journal of Physiology. 10, 2019  |   Pubmed ID: 31444905
• Intracellular Retention of Mutant Lysyl Oxidase Leads to Aortic Dilation in Response to Increased Hemodynamic Stress
  JCI Insight. 06, 2019  |   Pubmed ID: 31211696
• Decreased Lysyl Oxidase Level Protects Against Development of Retinal Vascular Lesions in Diabetic Retinopathy
  Experimental Eye Research. 07, 2019  |   Pubmed ID: 31022398
• Cardiovascular Consequences of KATP Overactivity in Cantu Syndrome
  JCI Insight. 08, 2018  |   Pubmed ID: 30089727
• Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis
  Current Topics in Developmental Biology. 2018  |   Pubmed ID: 29853177
• Spatial and Temporal Changes in Extracellular Elastin and Laminin Distribution During Lung Alveolar Development
  Scientific Reports. 05, 2018  |   Pubmed ID: 29844468
• Requisite Endothelial Reactivation and Effective SiRNA Nanoparticle Targeting of Etv2/Er71 in Tumor Angiogenesis
  JCI Insight. 04, 2018  |   Pubmed ID: 29669933
• Microfibril-associated Glycoproteins MAGP-1 and MAGP-2 in Disease
  Matrix Biology : Journal of the International Society for Matrix Biology. 10, 2018  |   Pubmed ID: 29524629
• Contribution of Metabolic Disease to Bone Fragility in MAGP1-deficient Mice
  Matrix Biology : Journal of the International Society for Matrix Biology. 04, 2018  |   Pubmed ID: 29519758
• Elastin in Lung Development and Disease Pathogenesis
  Matrix Biology : Journal of the International Society for Matrix Biology. 11, 2018  |   Pubmed ID: 29331337
• Elastin Purification and Solubilization
  Methods in Cell Biology. 2018  |   Pubmed ID: 29310779
• Measurement of Elastin, Collagen, and Total Protein Levels in Tissues
  Methods in Cell Biology. 2018  |   Pubmed ID: 29310774
• FGF Receptors Control Alveolar Elastogenesis
  Development (Cambridge, England). 12, 2017  |   Pubmed ID: 29122839
• Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced Apoptosis
  Investigative Ophthalmology & Visual Science. 05, 2017  |   Pubmed ID: 28538980
• Fibulin-4 is Essential for Maintaining Arterial Wall Integrity in Conduit but Not Muscular Arteries
  Science Advances. May, 2017  |   Pubmed ID: 28508064
• Inhibition of MAPK-Erk Pathway In vivo Attenuates Aortic Valve Disease Processes in Emilin1-deficient Mouse Model
  Physiological Reports. Mar, 2017  |   Pubmed ID: 28270590
• Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency
  Arteriosclerosis, Thrombosis, and Vascular Biology. 05, 2017  |   Pubmed ID: 28254817
• Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice
  Frontiers in Endocrinology. 2016  |   Pubmed ID: 27445989
• Loss of Function Mutation in LOX Causes Thoracic Aortic Aneurysm and Dissection in Humans
  Proceedings of the National Academy of Sciences of the United States of America. 08, 2016  |   Pubmed ID: 27432961
• Albumin Contributes to Kidney Disease Progression in Alport Syndrome
  American Journal of Physiology. Renal Physiology. 07, 2016  |   Pubmed ID: 27147675
• Characterization of Metabolic Health in Mouse Models of Fibrillin-1 Perturbation
  Matrix Biology : Journal of the International Society for Matrix Biology. 09, 2016  |   Pubmed ID: 26902431
• Chronic Antihypertensive Treatment Improves Pulse Pressure but Not Large Artery Mechanics in a Mouse Model of Congenital Vascular Stiffness
  American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2015  |   Pubmed ID: 26232234
• Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with Both Elastic Fiber and Collagen Fibril Abnormalities
  The Journal of Biological Chemistry. Aug, 2015  |   Pubmed ID: 26178373
• The Microfibril-associated Glycoproteins (MAGPs) and the Microfibrillar Niche
  Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2015  |   Pubmed ID: 25963142
• Adamtsl2 Deletion Results in Bronchial Fibrillin Microfibril Accumulation and Bronchial Epithelial Dysplasia--a Novel Mouse Model Providing Insights into Geleophysic Dysplasia
  Disease Models & Mechanisms. May, 2015  |   Pubmed ID: 25762570
• Fibroblast Growth Factor 2 is Required for Epithelial Recovery, but Not for Pulmonary Fibrosis, in Response to Bleomycin
  American Journal of Respiratory Cell and Molecular Biology. Jan, 2015  |   Pubmed ID: 24988442
• The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β
  Diabetes. Jun, 2014  |   Pubmed ID: 24458361
• Altered Reactivity of Resistance Vasculature Contributes to Hypertension in Elastin Insufficiency
  American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2014  |   Pubmed ID: 24414067
• Nonselective Assembly of Fibrillin 1 and Fibrillin 2 in the Rodent Ocular Zonule and in Cultured Cells: Implications for Marfan Syndrome
  Investigative Ophthalmology & Visual Science. Dec, 2013  |   Pubmed ID: 24265020
• Ocular Phenotype of Fbn2-null Mice
  Investigative Ophthalmology & Visual Science. Nov, 2013  |   Pubmed ID: 24130178
• Hypotension Due to Kir6.1 Gain-of-function in Vascular Smooth Muscle
  Journal of the American Heart Association. Aug, 2013  |   Pubmed ID: 23974906
• Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo
  The Journal of Biological Chemistry. Oct, 2013  |   Pubmed ID: 23963447
• Zap70 Inhibits Syk-mediated Osteoclast Function
  Journal of Cellular Biochemistry. Aug, 2013  |   Pubmed ID: 23494777
• Development, Composition, and Structural Arrangements of the Ciliary Zonule of the Mouse
  Investigative Ophthalmology & Visual Science. Apr, 2013  |   Pubmed ID: 23493297
• A Fiber-based Constitutive Model Predicts Changes in Amount and Organization of Matrix Proteins with Development and Disease in the Mouse Aorta
  Biomechanics and Modeling in Mechanobiology. Jun, 2013  |   Pubmed ID: 22790326
• Overview of Extracellular Matrix
  Current Protocols in Cell Biology. Dec, 2012  |   Pubmed ID: 23208544
• Paxillin Contracts the Osteoclast Cytoskeleton
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2012  |   Pubmed ID: 22807029
• Alternative Splicing and Tissue-specific Elastin Misassembly Act As Biological Modifiers of Human Elastin Gene Frameshift Mutations Associated with Dominant Cutis Laxa
  The Journal of Biological Chemistry. Jun, 2012  |   Pubmed ID: 22573328
• Oophorectomy-induced Bone Loss is Attenuated in MAGP1-deficient Mice
  Journal of Cellular Biochemistry. Jan, 2012  |   Pubmed ID: 21898536
• MicroRNA 29 的抑制作用增强弹性蛋白水平在单元格 Haploinsufficient 中的弹性蛋白和生物工程的船只。
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2011  |   Pubmed ID: 22095981
• Genetic Modifiers of Cardiovascular Phenotype Caused by Elastin Haploinsufficiency Act by Extrinsic Noncomplementation
  The Journal of Biological Chemistry. Dec, 2011  |   Pubmed ID: 22049077
• Pathogenesis of Aortic Dilatation in Mucopolysaccharidosis VII Mice May Involve Complement Activation
  Molecular Genetics and Metabolism. Dec, 2011  |   Pubmed ID: 21944884
• Characterization of Erectile Function in Elastin Haploinsufficicent Mice
  The Journal of Sexual Medicine. Nov, 2011  |   Pubmed ID: 21883953
• 直径减小到主动脉和法规遵从性中的弹性蛋白不足小鼠发育之前血压上升。
  American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2011  |   Pubmed ID: 21536846
• Oxidative Modifications of the C-terminal Domain of Tropoelastin Prevent Cell Binding
  The Journal of Biological Chemistry. Apr, 2011  |   Pubmed ID: 21321118
• New Insights into the Pathogenesis of Autosomal-dominant Cutis Laxa with Report of Five ELN Mutations
  Human Mutation. Apr, 2011  |   Pubmed ID: 21309044
• Evidence for Heterozygous Abnormalities of the Elastin Gene (ELN) Affecting the Quantity of Vocal Fold Elastic Fibers: a Pilot Study
  Journal of Voice : Official Journal of the Voice Foundation. Mar, 2011  |   Pubmed ID: 20926252
• Oxidative and Nitrosative Modifications of Tropoelastin Prevent Elastic Fiber Assembly in Vitro
  The Journal of Biological Chemistry. Nov, 2010  |   Pubmed ID: 20847053
• The Matrix-binding Domain of Microfibril-associated Glycoprotein-1 Targets Active Connective Tissue Growth Factor to a Fibroblast-produced Extracellular Matrix
  Macromolecular Bioscience. Nov, 2010  |   Pubmed ID: 20799254
• Mechanisms of Emphysema in Autosomal Dominant Cutis Laxa
  Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2010  |   Pubmed ID: 20600892
• Microfibril-associated Glycoprotein-1, an Extracellular Matrix Regulator of Bone Remodeling
  The Journal of Biological Chemistry. Jul, 2010  |   Pubmed ID: 20501659
• 离散的动脉的发展和机械法规遵从性弹性纤维组件提供的捐款。
  Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2009  |   Pubmed ID: 19850904
• 血管细胞外基质和动脉力学。
  Physiological Reviews. Jul, 2009  |   Pubmed ID: 19584318
• Effects of Chronic Treatment with a Low Dose of Nicorandil on the Function of the Rat Aorta During Ageing
  Clinical and Experimental Pharmacology & Physiology. Oct, 2009  |   Pubmed ID: 19473347
• 减少的血管的弹性改变心血管结构和功能的新生小鼠。
  Circulation Research. May, 2009  |   Pubmed ID: 19372465
• Fibrillins, Fibulins, and Matrix-associated Glycoprotein Modulate the Kinetics and Morphology of in Vitro Self-assembly of a Recombinant Elastin-like Polypeptide
  Biochemistry. Nov, 2008  |   Pubmed ID: 18973305
• Essential Role for Fibrillin-2 in Zebrafish Notochord and Vascular Morphogenesis
  Developmental Dynamics : an Official Publication of the American Association of Anatomists. Oct, 2008  |   Pubmed ID: 18816837
• Elastin Insufficiency Predisposes to Elevated Pulmonary Circulatory Pressures Through Changes in Elastic Artery Structure
  Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2008  |   Pubmed ID: 18772328
• Deficiency in Microfibril-associated Glycoprotein-1 Leads to Complex Phenotypes in Multiple Organ Systems
  The Journal of Biological Chemistry. Sep, 2008  |   Pubmed ID: 18625713
• Modification and Functional Inactivation of the Tropoelastin Carboxy-terminal Domain in Cross-linked Elastin
  Matrix Biology : Journal of the International Society for Matrix Biology. Sep, 2008  |   Pubmed ID: 18602002
• 主动脉扩张黏在我的弹性蛋白酶蛋白表达上调导致小鼠。
  Molecular Genetics and Metabolism. Jul, 2008  |   Pubmed ID: 18479957
• Methods in Elastic Tissue Biology: Elastin Isolation and Purification
  Methods (San Diego, Calif.). May, 2008  |   Pubmed ID: 18442703
• Mice Lacking the Extracellular Matrix Protein MAGP1 Display Delayed Thrombotic Occlusion Following Vessel Injury
  Blood. Apr, 2008  |   Pubmed ID: 18281502
• Neutrophil Elastase Cleaves Laminin-332 (laminin-5) Generating Peptides That Are Chemotactic for Neutrophils
  The Journal of Biological Chemistry. Apr, 2008  |   Pubmed ID: 18178964
• Elastin Haploinsufficiency Induces Alternative Aging Processes in the Aorta
  Rejuvenation Research. Feb, 2008  |   Pubmed ID: 18173368
• Fibulin-2 is Dispensable for Mouse Development and Elastic Fiber Formation
  Molecular and Cellular Biology. Feb, 2008  |   Pubmed ID: 18070922
• 弹性纤维大会的新见解。
  Birth Defects Research. Part C, Embryo Today : Reviews. Dec, 2007  |   Pubmed ID: 18228265
• The Intracellular Form of Human MAGP1 Elicits a Complex and Specific Transcriptional Response
  The International Journal of Biochemistry & Cell Biology. 2007  |   Pubmed ID: 17692555
• Functional Rescue of Elastin Insufficiency in Mice by the Human Elastin Gene: Implications for Mouse Models of Human Disease
  Circulation Research. Aug, 2007  |   Pubmed ID: 17626896
• 弹性蛋白不足小鼠显示正常心血管重塑的 2 肾 1 夹高血压尽管有较高的比较基准压力和独特的心血管体系结构。
  American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2007  |   Pubmed ID: 17400710
• Elastin Protein Levels Are a Vital Modifier Affecting Normal Lung Development and Susceptibility to Emphysema
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2007  |   Pubmed ID: 17142349
• Domains 16 and 17 of Tropoelastin in Elastic Fibre Formation
  The Biochemical Journal. Feb, 2007  |   Pubmed ID: 17037986
• Fibulin-5 Mutations: Mechanisms of Impaired Elastic Fiber Formation in Recessive Cutis Laxa
  Human Molecular Genetics. Dec, 2006  |   Pubmed ID: 17035250
• The Stumbling Block in Lung Repair of Emphysema: Elastic Fiber Assembly
  Proceedings of the American Thoracic Society. Jul, 2006  |   Pubmed ID: 16799087
• Specific Sequence Motifs Direct the Oxygenation and Chlorination of Tryptophan by Myeloperoxidase
  Biochemistry. Mar, 2006  |   Pubmed ID: 16548523
• Elastin Fragments Drive Disease Progression in a Murine Model of Emphysema
  The Journal of Clinical Investigation. Mar, 2006  |   Pubmed ID: 16470245
• 弹性纤维形成： 使用计时器记者的细胞外基质程序集的动态视图。
  Journal of Cellular Physiology. Apr, 2006  |   Pubmed ID: 16261592
• Tropoelastin Interacts with Cell-surface Glycosaminoglycans Via Its COOH-terminal Domain
  The Journal of Biological Chemistry. Dec, 2005  |   Pubmed ID: 16192266
• A Functional Mutation in the Terminal Exon of Elastin in Severe, Early-onset Chronic Obstructive Pulmonary Disease
  American Journal of Respiratory Cell and Molecular Biology. Oct, 2005  |   Pubmed ID: 16081882
• 弹性蛋白 Haploinsufficiency 对小鼠动脉的力学行为的影响。
  American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2005  |   Pubmed ID: 15863465
• Altered Vascular Remodeling in Fibulin-5-deficient Mice Reveals a Role of Fibulin-5 in Smooth Muscle Cell Proliferation and Migration
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15710889
• TGF-beta-dependent Pathogenesis of Mitral Valve Prolapse in a Mouse Model of Marfan Syndrome
  The Journal of Clinical Investigation. Dec, 2004  |   Pubmed ID: 15546004
• Vascular Extracellular Matrix and Aortic Development
  Current Topics in Developmental Biology. 2004  |   Pubmed ID: 15522742
• Deposition of Tropoelastin into the Extracellular Matrix Requires a Competent Elastic Fiber Scaffold but Not Live Cells
  Matrix Biology : Journal of the International Society for Matrix Biology. Apr, 2004  |   Pubmed ID: 15172035
• Neutrophil Serine Proteinases Inactivate Surfactant Protein D by Cleaving Within a Conserved Subregion of the Carbohydrate Recognition Domain
  The Journal of Biological Chemistry. Jun, 2004  |   Pubmed ID: 15078883
• Identification of a Major Microfibril-associated Glycoprotein-1-binding Domain in Fibrillin-2
  The Journal of Biological Chemistry. May, 2004  |   Pubmed ID: 15044481
• 鼠标的心血管系统对弹性蛋白 Haploinsufficiency 发展适应。
  The Journal of Clinical Investigation. Nov, 2003  |   Pubmed ID: 14597767
• Dexamethasone Induction of Hypertension and Diabetes is PPAR-alpha Dependent in LDL Receptor-null Mice
  Nature Medicine. Aug, 2003  |   Pubmed ID: 12847522
• Fibrillin-1 and -2 Contain Heparin-binding Sites Important for Matrix Deposition and That Support Cell Attachment
  The Biochemical Journal. Oct, 2003  |   Pubmed ID: 12837131
• A Site on Laminin Alpha 5, AQARSAASKVKVSMKF, Induces Inflammatory Cell Production of Matrix Metalloproteinase-9 and Chemotaxis
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003  |   Pubmed ID: 12817023
• Domains in Tropoelastin That Mediate Elastin Deposition in Vitro and in Vivo
  The Journal of Biological Chemistry. May, 2003  |   Pubmed ID: 12626514
• Hypertension and Prolonged Vasoconstrictor Signaling in RGS2-deficient Mice
  The Journal of Clinical Investigation. Feb, 2003  |   Pubmed ID: 12588882
• Lysyl Oxidase is Required for Vascular and Diaphragmatic Development in Mice
  The Journal of Biological Chemistry. Apr, 2003  |   Pubmed ID: 12473682
• The Microfibrillar Proteins MAGP-1 and Fibrillin-1 Form a Ternary Complex with the Chondroitin Sulfate Proteoglycan Decorin
  Molecular Biology of the Cell. May, 2000  |   Pubmed ID: 10793130
• Characterization of an in Vitro Model of Elastic Fiber Assembly
  Molecular Biology of the Cell. Nov, 1999  |   Pubmed ID: 10564258
• Identification of Tropoelastin As a Ligand for the 65-kD FK506-binding Protein, FKBP65, in the Secretory Pathway
  The Journal of Cell Biology. Jan, 1998  |   Pubmed ID: 9442105
• Chlamydomonas Agglutinin is a Hydroxyproline-rich Glycoprotein
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 1983  |   Pubmed ID: 16593377