Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction (Video) | JoVE

Terrence Wong; Roslyn Tedja; Hussein Chehade; Robert Morris; Ayesha B. Alvero; Gil Mor

doi:10.3791/66031

Establishing a 3D Ex Vivo Model for Ovarian Cancer-Omentum Interaction

January 26th, 2024

Advanced Ex Vivo Model for Investigating Cancer-Adipose Microenvironment Interaction (Video) | JoVE

01:38 min

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Human Omentum Specimen Processing and Co-Culture with Ovarian Cancer Cells (Video) | JoVE

04:24 min

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Terrence Wong¹, Roslyn Tedja², Hussein Chehade², Robert Morris¹, Ayesha B. Alvero², Gil Mor²

¹Department of Gynecologic Oncology, Karmanos Cancer Institute, ²C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University School of Medicine

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This protocol describes the establishment of a three-dimensional (3D) ex vivo model of cancer cell-omentum interaction. The model provides a platform for elucidating pro-tumor mechanisms within the adipose niche and for testing novel therapies.

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Establishing a 3D Ex Vivo Model for Ovarian Cancer-Omentum Interaction

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