Pyrolobus Fumarii

Pyrolobus fumarii is a hyperthermophilic archaeon, or heat-loving microorganism, that thrives at temperatures near and above the boiling point of water in deep-sea hydrothermal vents. It grows anaerobically by oxidizing molecular hydrogen and using nitrate as a terminal electron acceptor, while fixing carbon dioxide to build cellular material. This metabolism allows P. fumarii to obtain energy under the high-temperature, oxygen-limited conditions of the seafloor and makes it an important model for studying extremophile biology, archaeal energy conservation, and the limits of life. Its heat-stable enzymes may also support biotechnology in demanding industrial processes.

Pyrolobus Fumarii - Related Videos

Research

JoVE Journal - Cancer Research

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells

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Cited by 6 •

2017

This procedure will demonstrate how we synthesized and characterized the anti-NFκB and anti-cancer stem cell activity of an aspirin-fumarate prodrug.

Education

JoVE Core - Biology

The Citric Acid Cycle

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2019

The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules. Acetyl CoA is the point-of-entry into the citric acid cycle, which occurs in the inner membrane (i.e., matrix) of mitochondria in eukaryotic cells or the cytoplasm of prokaryotic cells. Prior to the citric acid cycle, pyruvate oxidation produced two acetyl CoA molecules per glucose...

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