Nose-only Inhalation
Nose-only Inhalation - Related Videos
07:28
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
0 Views •
Cited by 11 •
2017
The inhalation unit described herein can generate, sample for characterization, and uniformly deposit a drug aerosol in the lungs of rodents. This enables the pre-clinical determination of the efficacy and safety of drug doses deposited in the lungs; key data enabling clinical inhaled drug development.
05:07
Development of a Nose-only Inhalation Toxicity Test Chamber That Provides Four Exposure Concentrations of Nano-sized Particles
0 Views •
Cited by 2 •
2019
A nose-only inhalation toxicity chamber capable of testing inhalation toxicity at four different exposure concentrations was designed and validated for flow field uniformity and cross-contamination between the exposure ports for each concentration. Here, we present a protocol to confirm that the designed chamber is effective for inhalation toxicity testing.
05:44
Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
0 Views •
Cited by 14 •
2018
Here, we describe two novel methods of stable intranasal administration under inhalation anesthesia with minimal physical stress for experimental animals. We also describe a method for quantitative evaluation of drug distribution levels in the brain via the nose-to-brain pathway using radiolabeled [14C]-inulin as a model substrate of water-soluble macromolecules.
08:46
Nose, Sinuses, Oral Cavity and Pharynx Exam
0 Views •
2023
Source: Richard Glickman-Simon, MD, Assistant Professor, Department of Public Health and Community Medicine, Tufts University School of Medicine, MA This video provides an overview of sinus, nose, and throat examinations. The demonstration begins with a brief overview of the anatomy of the region. The upper third of the nose is bony, and the bottom two-thirds are cartilaginous. Air entering the nares passes through the nasal vestibules and into the narrow passageway between the nasal septum...
09:33
MRI Mapping of Cerebrovascular Reactivity via Gas Inhalation Challenges
0 Views •
Cited by 79 •
2014
Non-invasive imaging of the brain vasculature’s ability to dilate or constrict may allow a better understanding of cerebrovascular pathophysiology in various neurological diseases. The present report describes a reproducible and patient-comfortable protocol to perform vascular reactivity imaging in humans using magnetic resonance imaging (MRI).
FAQs
Particle size and concentration are central control variables because they define the inhaled exposure delivered during the session. Keeping these features specified allows investigators to relate respiratory effects to a known aerosol rather than an imprecise environmental mixture. In infection and immunology studies, that control helps compare pathogen-exposure conditions or evaluate how respiratory tissues respond to differing exposure settings.
Specialized restraint or exposure systems help preserve route specificity. By limiting contact with other body surfaces, they reduce the possibility that observed effects arise from ingestion or dermal exposure instead of nasal inhalation. This distinction is important when interpreting inflammation, immune responses, or infection-related findings, because route-specific effects can otherwise be difficult to separate from responses caused by unintended contact.
Measured exposure duration provides an essential reference point for interpreting results. It lets investigators relate immune, inflammatory, or infection-associated outcomes to a defined period of respiratory exposure, rather than to an unknown contact time. Duration therefore works with particle size and concentration to improve exposure control and support comparisons among experimental conditions.
The procedure begins by preparing an aerosol or vapor with defined particle size and concentration, then placing the subject in a specialized system that restricts exposure to the nasal passages. The subject breathes the material for a measured duration, after which investigators assess selected respiratory, inflammatory, immune, or infection-related outcomes. The system’s design supports consistent exposure conditions.
Nose-only inhalation is suited to studies of pathogen transmission, mucosal immune responses, pulmonary inflammation, and respiratory vaccine or therapeutic delivery. These applications share a need to examine effects initiated through the respiratory route. The approach can also help investigators distinguish responses associated with inhalation from those produced by ingestion or dermal contact, strengthening interpretation of immune and infection findings.
Findings should be considered in relation to the controlled exposure variables and the route-specific design. A response observed after a defined aerosol or vapor exposure can be compared with the measured duration, particle size, and concentration, while restricted body-surface contact helps attribute effects to inhalation. This framework supports clearer interpretation of mucosal, pulmonary, inflammatory, and infection-related outcomes.