Fetal To Neonatal Transition
Fetal To Neonatal Transition - Related Videos
08:15
Recapitulating Suckling-to-Weaning Transition In Vitro using Fetal Intestinal Organoids
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Cited by 7 •
2019
This protocol describes how to mimic suckling-to-weaning transition in vitro using mouse late fetal intestinal organoids cultured for 30 days.
14:19
Fetal Echocardiography and Pulsed-wave Doppler Ultrasound in a Rabbit Model of Intrauterine Growth Restriction
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Cited by 11 •
2013
We describe examination of fetal cardiac function with contemporary functional fetal echocardiography and fetoplacental Doppler ultrasound using the VisualSonics VEVO 2100 microultrasound in a surgically induced model of intrauterine fetal growth restriction in a rabbit.
02:31
Phase Transitions
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2020
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to occupy...
08:04
Murine Fetal Echocardiography
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Cited by 7 •
2013
Fetal and perinatal death is a common feature when studying genetic alterations affecting cardiac development. High-frequency ultrasound imaging has improved 2-D resolution and can provide excellent information on early cardiac development and is an ideal method to detect the impact on cardiac structure and function prior to death.
08:38
A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition
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Cited by 5 •
2023
This work presents an animal model of endothelial-to-mesenchymal transition-induced fibrosis, as seen in congenital cardiac defects such as critical aortic stenosis or hypoplastic left heart syndrome, which allows for detailed histological tissue evaluation, the identification of regulatory signaling pathways, and the testing of treatment options.
FAQs
The first breaths do more than initiate air movement: lung expansion lowers pulmonary vascular resistance, allowing pulmonary blood flow to rise. This replaces placental gas exchange with gas exchange through the lungs and changes the pressure relationships that govern newborn circulation. In clinical assessment, inadequate respiratory adaptation can therefore signal that the transition is not progressing normally and may require prompt support.
Umbilical cord clamping removes the placental circulation, which raises systemic vascular resistance. At the same time, increased pulmonary blood flow alters the balance between the right- and left-sided circulations. Together, these shifts promote functional closure of the foramen ovale and ductus arteriosus, helping reorganize blood flow from the fetal pattern toward the neonatal pattern.
Fetal to neonatal transition depends on coordinated respiratory and circulatory changes rather than a single event. Breathing lowers pulmonary vascular resistance, while cord clamping raises systemic vascular resistance; the resulting redistribution of blood flow supports functional closure of the fetal shunts. This coordination explains why respiratory and circulatory assessment are both important when judging newborn adaptation.
Clinical support focuses on restoring the changes needed for effective adaptation. When respiratory compromise interferes with lung expansion and gas exchange, ventilation can help initiate or support the pulmonary changes required for increased pulmonary blood flow. Neonatal resuscitation provides the broader intervention framework for newborns who do not adapt adequately, with timing guided by assessment of respiratory and circulatory compromise.
In medicine, this framework helps clinicians distinguish expected adaptation from birth-related compromise. It provides a physiological basis for assessing whether the newborn is making the necessary respiratory and circulatory adjustments, then deciding whether timely intervention is needed. The same principles guide investigation of prematurity and other birth-related complications in which transition may be more difficult.
Research on fetal to neonatal transition extends beyond immediate resuscitation. Investigators use it to examine how placental support, pulmonary blood flow, systemic resistance, and fetal shunts are reorganized at birth. This work contributes to developmental cardiovascular physiology and can clarify how altered adaptation relates to respiratory or circulatory compromise in the newborn.