Mri Utility
Mri Utility - Related Videos
15:53
Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning
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Cited by 33 •
2016
The overall goal of this protocol is to accurately align magnetic resonance imaging (MRI) image volumes with histology sections via the creation of customized 3D-printed brain holders and slicer boxes.
06:06
Optogenetic Functional MRI
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Cited by 15 •
2016
This protocol describes the steps and data analysis required to successfully perform optogenetic functional magnetic resonance imaging (ofMRI). ofMRI is a novel technique that combines high-field fMRI readout with optogenetic stimulation, allowing for cell type-specific mapping of functional neural circuits and their dynamics across the whole living brain.
08:20
MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
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Cited by 31 •
2015
Here we outline the procedure for MRI-guided repetitive transcranial magnetic stimulation to the dorsomedial prefrontal cortex as an experimental treatment for major depressive disorder.
06:58
Synthesis of an In vivo MRI-detectable Apoptosis Probe
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Cited by 3 •
2012
Early detection of apoptosis may identify at-risk cell populations in a variety of diseases. Here we demonstrate a method to link an early apoptosis-detection protein (Annexin V) to a MRI-detectable iron oxide nanoparticle (SPIO). This method may be extended to other proteins of interest to generate MRI-detectable molecular imaging probes.
16:20
Hyperpolarized Xenon for NMR and MRI Applications
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Cited by 28 •
2012
The production of hyperpolarized xenon by means of spin exchange optical pumping (SEOP) is described. This method yields a ~10000-fold enhancement of the nuclear spin polarization of Xe-129 and has applications in nuclear magnetic resonance spectroscopy and imaging. Examples of gas phase and solution state experiments are given.
FAQs
Contrast arises because hydrogen nuclei respond to radiofrequency pulses and then return toward their original alignment at different rates. MRI detects these relaxation signals and uses their differences to distinguish tissues. This tissue-sensitive contrast can reveal structural abnormalities that may not be apparent from anatomy alone, supporting lesion characterization and more focused clinical interpretation.
Flexible protocols allow imaging to be adjusted to the information needed in a particular examination. A study can emphasize tissue-sensitive contrast, anatomical detail, or functional information rather than applying one fixed approach to every body region. This adaptability helps MRI address varied questions involving the brain, spine, joints, organs, blood vessels, and soft tissues.
MRI combines detailed imaging with tissue-sensitive contrast and multiplanar views, allowing internal structures to be examined from multiple orientations. It also avoids ionizing radiation, which is important when the clinical or research question requires repeated or especially detailed assessment. These characteristics help distinguish abnormalities and define their anatomical relationships.
During acquisition, the body is positioned within a strong magnetic field, and radiofrequency pulses alter the alignment of hydrogen nuclei. The system measures the signals released as those nuclei relax, then reconstructs the measurements into images. The resulting data can be organized into multiplanar views and interpreted according to the examination's clinical or research purpose.
MRI can contribute at several points in care: detecting abnormalities, characterizing lesions, planning treatment, and monitoring response. Its value therefore extends beyond identifying whether a structure looks unusual. By providing detailed, tissue-sensitive and multiplanar information, it helps clinicians assess the location and appearance of findings and evaluate change over time.
In clinical medicine, MRI supplies information for evaluating disease across many body regions and for guiding management. In research, the same capacity to produce detailed anatomical, tissue-sensitive, and functional information supports investigation of internal structures and abnormalities. Its noninvasive nature and lack of ionizing radiation further contribute to its usefulness when repeated or detailed imaging is needed.