Reversible Uuo Model
Reversible Uuo Model - Related Videos
14:05
A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
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Cited by 47 •
2014
The murine model of irreversible unilateral ureteric obstruction (UUO) is presented together with the model of reversible UUO in which the ureteric obstruction is relieved by anastomosis of the severed ureter into the bladder. These models enable the study of renal inflammation and scarring as well as tissue remodeling.
09:39
Creation of Reversible Cholestatic Rat Model
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2011
Cholestasis is a clinical condition commonly encountered by both surgeons and gastroenterologists. Creation of a reversible cholestatic rat model can be challenging in view of the smaller size and unique hepatopancreatobiliary anatomy in rats. This video article demonstrates the creation of a reversible cholestatic model.
01:14
Modeling of Diode Reverse Characteristics
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2024
In electronic circuits, reverse-biased diode configurations are critical for regulating voltage levels. Zener diodes exploit the reverse breakdown phenomenon and exhibit a controlled breakdown at a specific Zener voltage (VZ). They are designed to maintain a constant voltage across their terminals and are commonly used for voltage regulation in circuits. When a reverse voltage applied to a Zener diode exceeds its breakdown voltage, the diode enters the breakdown region. At this point, the...
10:58
Obtaining Specimens with Slowed, Accelerated and Reversed Aging in the Honey Bee Model
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Cited by 19 •
2013
In honey bee workers, aging depends on social behaviors rather than on chronological age. Here we show how worker-types with very different aging patterns can be obtained and analyzed for cellular senescence.
10:10
Reverse Total Shoulder Arthroplasty
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Cited by 5 •
2011
Reverse total shoulder arthroplasty is indicated for the treatment of conditions that cannot be treated with conventional arthroplasty or other procedures. These primarily include degenerative and incapacitating conditions with irreparable rotator cuff and loss of the normal biomechanical coupling of the shoulder.
FAQs
Increased pressure within the obstructed kidney is a central driver of tubular damage, inflammation, and interstitial fibrosis. These linked responses allow investigators to examine how impaired urine flow progresses from an initial pressure-related disturbance toward structural injury. Studying this sequence helps clarify which pathological changes may persist and which may respond after the obstruction is relieved.
Relieving the obstruction creates an opportunity to follow the kidney beyond the injury phase and distinguish reversible changes from persistent damage. Researchers can compare findings during obstruction with those observed after decompression, then assess whether tubular injury, inflammation, or fibrosis improves, remains detectable, or progresses. This recovery-focused comparison is a key advantage of the model.
Interstitial fibrosis provides an indicator of structural remodeling that may remain after the obstructive period. Its inclusion alongside tubular damage and inflammation allows studies to examine injury and repair as related but distinguishable outcomes. In medicine, this is particularly relevant when evaluating whether an intervention limits fibrotic change or supports preservation of renal function.
The workflow has two essential phases: researchers first create unilateral ureteral obstruction and maintain it for a defined experimental period, then relieve the blockage to initiate decompression. Measurements or tissue assessments can be made during obstruction and after release. Comparing these stages shows how renal injury develops and how the affected kidney changes during recovery.
Post-release assessment provides information about the trajectory of renal injury rather than only its peak expression during obstruction. Investigators can determine whether changes in tubular damage, inflammation, and interstitial fibrosis improve after decompression or remain persistent. These observations help separate recovery-associated responses from pathological features that may indicate lasting impairment.
The model is useful when a therapy is intended to limit obstructive nephropathy, reduce fibrosis, or preserve renal function. Treatment effects can be examined during the obstruction period and again after the blockage is relieved, allowing investigators to ask whether an intervention reduces injury, improves recovery, or influences both phases. This makes it relevant to studies of renal repair.