Symptomatic Fibroids

Symptomatic fibroids are noncancerous growths of the uterine smooth muscle that cause clinically significant symptoms and may affect daily life, fertility, or pregnancy. These hormone-responsive tumors develop within or around the uterus, and their size, number, and location can disrupt the uterine cavity or compress nearby structures, leading to heavy menstrual bleeding, pelvic pain, pressure, urinary symptoms, or reproductive difficulties. Evaluation commonly combines medical history, pelvic examination, and imaging such as ultrasound. Treatment is individualized and may include medication to control bleeding or pain, minimally invasive procedures, or surgery, making accurate assessment important for preserving health and guiding reproductive decisions.

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Research

JoVE EoE - Neurotherapeutics

Stromal Vascular Fraction-Enriched Fat Grafting for the Management of Symptomatic Neuromas

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2025

Source: Zimmermann, S., et.al. Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata. J. Vis. Exp. (2017)This video demonstrates the surgical procedure for neurolysis and stromal vascular fraction (SVF)-enriched fat grafting in the management of symptomatic neuroma. Neurolysis removes adhesion tissue to restore nerve gliding, while SVF-enriched fat grafting is applied around the nerve to create a protective barrier, support nerve healing, and enhance...

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata

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Cited by 8 •

2017

The purpose of the study is to illustrate the technical procedure of stromal vascular fraction (SVF)-enriched fat grafting as a novel treatment of symptomatic end-neuromata. This technique provides advantages of both the mechanical barrier and the biological action at the cellular level by the processed and concentrated SVF.

Research

JoVE Journal - Neuroscience
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Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

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Cited by 3 •

2020

We provide a protocol to generate a pharmacological DYT/PARK-ATP1A3 dystonia mouse model via implantation of cannulas into basal ganglia and cerebellum connected to osmotic pumps. We describe the induction of dystonia-like movements via application of a motor challenge and the characterization of the phenotype via behavioral scoring systems.

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment

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Cited by 11 •

2015

We herein describe the method of fibered confocal fluorescent microscopy (FCFM) based imaging, which provides an innovative mode to understand physiological phenomena at the cellular and sub-cellular levels in animal subjects.

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy

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Cited by 49 •

2013

This article presents a method for measuring the working abdominal volume during laproscopic myomectomy using the surgical grasper, and applies this technique to obtain pilot data on whether deep neuromuscular blockade (NMB) can enable the use of lower insufflation pressure. Reduced insufflation pressure during laproscopic surgery has been shown to reduce post-operative pain, and thus the use of NMB during surgery may enable improved patient outcomes.

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