Post-injury Treatment
Post-injury Treatment - Related Videos
09:09
Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
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Cited by 141 •
2013
We describe models of moderate and severe ischemia-reperfusion-induced kidney injury in which the mice undergo unilateral renal pedicle clamping followed by simultaneous or delayed contralateral nephrectomy, respectively. These models consistently give rise to renal dysfunction and post-injury fibrosis, but injury severity and survival are dependent on mouse background, age and surgical equipment.
09:09
A Murine Model of Cervical Spinal Cord Injury to Study Post-lesional Respiratory Neuroplasticity
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Cited by 16 •
2014
Respiratory failure is the leading cause of death following a cervical spinal cord injury. Having a reproducible, quantifiable, and reliable pre-clinical animal model of respiratory failure induced by a partial cervical injury will help to understand the subsequent respiratory and non-respiratory neuroplasticity and allow testing putative repair strategies.
01:47
Technique to Induce Post-Traumatic Seizures in a Mouse Model via a Weight Drop Traumatic Injury
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2025
Source: Shandra, O. et al., Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury. J. Vis. Exp.
08:24
Establishing a Swine Model of Post-myocardial Infarction Heart Failure for Stem Cell Treatment
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Cited by 11 •
2020
We sought to establish a swine model of heart failure induced by left circumflex artery blockage and rapid pacing to test the effect and safety of intramyocardial administration of stem cells for cell-based therapies.
11:04
Lateral Fluid Percussion: Model of Traumatic Brain Injury in Mice
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Cited by 125 •
2011
Lateral fluid percussion (LFP), an established model of traumatic brain injury in mice, is demonstrated. LFP fulfills three major criteria for animal models: validity, reliability and clinical relevance. The procedure, consisting of surgical craniotomy, fixation of hub followed by induction of injury, resulting in focal and diffuse injuries, is described.
FAQs
Severity assessment helps determine whether care should focus on immediate measures, continued observation, or more intensive intervention. Clinicians consider the extent of damage and possible complications before selecting wound protection, pain management, immobilization, or surgical repair. This approach matches treatment intensity to the injury and helps limit additional damage during recovery.
These factors influence which treatments are appropriate and how quickly care should progress. An injured structure may require protection or immobilization, while the timing of care affects decisions about immediate management and later rehabilitation. The patient’s condition also guides treatment adaptation, helping clinicians balance healing needs with safety and functional recovery.
Graded rehabilitation uses progressively guided movement and exercise rather than an abrupt return to activity. This process supports tissue recovery while helping restore function over time. Progress can be adapted to the injured structure and the patient’s condition, making rehabilitation useful for monitoring recovery and informing decisions about resuming normal activities.
Follow-up should assess for infection, impaired healing, and loss of function. These problems may indicate that the injury is not progressing as expected or that the current care plan needs adjustment. Monitoring also provides information for deciding whether additional treatment, continued protection, or changes in rehabilitation are needed during recovery.
Care generally begins by assessing injury severity and possible complications. Immediate management may then control bleeding, protect the wound, manage pain, or immobilize the affected area. Surgical repair is considered when indicated, followed by rehabilitation using graded movement and exercise. Follow-up evaluates healing, function, and readiness for normal activity.
Immobilization helps protect the affected area while healing progresses, whereas surgical repair is used when the injury requires operative correction. Neither approach is selected in isolation; decisions depend on injury severity, the affected structure, timing, and the patient’s condition. Subsequent monitoring and rehabilitation help evaluate healing and functional recovery.
It is relevant whenever physical trauma creates a need to limit further damage, support healing, or recover lost function. Medical teams use assessment, targeted treatment, monitoring, and rehabilitation to manage changing needs over time. The resulting information supports follow-up decisions and helps determine when a patient can safely return to normal activity.