Journal
/
Médecine
/
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
Journal JoVE
Médecine
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Médecine
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

DOI:
10.3791/59646-v

•

05:08 min

•

October 03, 2019

•

, , , , ,
1Department of Anesthesiology,University of California, 2Department of Medicine,University of California, 3Department of Microbiology, Immunology & Molecular Genetics,University of California, 4Department of Molecular, Cell, and Developmental Biology,University of California

Chapitres

  • 00:04Titre
  • 00:40Isoproterenol (ISO) Osmotic Pump Preparation
  • 02:00ISO Osmotic Pump Surgical Implantation
  • 03:17Results: Representative Changes in Echocardiographic Measures in Different Mouse Strains and After Isoproterenol
  • 04:06Conclusion

Summary

Traduction automatique

Traduction automatique

The chronic administration of isoproterenol via an implanted osmotic pump has been used widely to mimic advanced heart failure in mice. Here, we describe detailed methods in surgical mini-pump implantation for the continuous isoproterenol administration over 3 weeks, as well as, echocardiographic assessment for the successful model creation.

Tags

Artificial IntelligenceAI Writing AssistantContent GenerationCopywritingText GenerationAI-generated ContentAutomated TextContent CreationAI-powered Writing

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Implantation of the Syncardia Total Artificial Heart

Implantation of Total Artificial Heart in Congenital Heart Disease

Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure

A Magnetic Microbead Occlusion Model to Induce Ocular Hypertension-Dependent Glaucoma in Mice

Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Read Article