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JoVE Journal Medicine
Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
 

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Article doi: 10.3791/59646
October 3rd, 2019 •
1, 2, 3, 4, 1, 2
1Department of Anesthesiology, University of California, 2Department of Medicine, University of California, 3Department of Microbiology, Immunology & Molecular Genetics, University of California, 4Department of Molecular, Cell, and Developmental Biology, University of California

Summary
Automatic Translation
October 3rd, 2019

The chronic administration of isoproterenol via an implanted osmotic pump has been used widely to mimic advanced heart failure in mice. Here, we describe detailed methods in surgical mini-pump implantation for the continuous isoproterenol administration over 3 weeks, as well as, echocardiographic assessment for the successful model creation.

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