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Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice
 

Implantation of an Isoproterenol Mini-Pump to Induce Heart Failure in Mice

Article doi: 10.3791/59646
October 3rd, 2019

Summary October 3rd, 2019

The chronic administration of isoproterenol via an implanted osmotic pump has been used widely to mimic advanced heart failure in mice. Here, we describe detailed methods in surgical mini-pump implantation for the continuous isoproterenol administration over 3 weeks, as well as, echocardiographic assessment for the successful model creation.

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