Ruthenium Uptake
Ruthenium Uptake - Related Videos
07:12
Synthesis and Evaluation of a Ruthenium-based Mitochondrial Calcium Uptake Inhibitor
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Cited by 5 •
2017
A protocol for the synthesis, purification, and characterization of a ruthenium-based inhibitor of mitochondrial calcium uptake is presented. A procedure to evaluate its efficacy in permeabilized mammalian cells is demonstrated.
10:51
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
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Cited by 4 •
2015
Ruthenium phosphine complexes are widely used for homogeneous catalytic reactions such as hydrogenations. The synthesis of a series of novel tridentate ruthenium complexes bearing the N-triphos ligand N(CH2PPh2)3 is reported. Additionally, the stoichiometric reaction of a dihydride Ru–N-triphos complex with levulinic acid is described.
04:04
Radiolabeled Amino Acid Uptake Assay to Quantify Cellular Uptake of Amino Acids
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2025
This video demonstrates an in vitro technique for estimating amino acid uptake by bone marrow-derived stromal cells. Na+-dependent amino acid transporters mediate the uptake of radiolabeled amino acids inside the cells, and the cellular uptake is estimated by measuring the radioactivity.
08:46
Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
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2022
The increased rate of pharmaco- and toxicokinetic analyses of metals and metal-based compounds in zebrafish can be advantageous for environmental and clinical translation studies. The limitation of unknown waterborne exposure uptake was overcome by conducting trace metal analysis on digested zebrafish tissue using inductively coupled plasma mass spectrometry.
03:03
Double-Staining Method: A Technique to Visualize Plant-Fungus Interactions Using Ruthenium Red and Lactophenol Cotton Blue
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2025
This video demonstrates a double staining method using ruthenium red and lactophenol cotton blue to visualize pectins and chitins during plant-fungus interactions in a coffee rust plant. The procedure helps understand plant defense mechanisms during fungal infections.
FAQs
Oxidation state affects how a ruthenium species interacts with its surrounding system, including its ligand environment, charge, solubility, and available binding sites. These properties can alter the tendency of the species to form coordination bonds or undergo ligand exchange. Examining oxidation state therefore helps explain differences in retention, distribution, and reactivity during uptake.
Ligand exchange can replace molecules or groups surrounding ruthenium, creating new opportunities for interaction with a binding site, membrane, or solid surface. The resulting coordination bonds help determine whether the metal complex is temporarily associated or efficiently retained. Studying these changes connects molecular structure with the observed stability and accumulation of ruthenium.
Charge and solubility influence how readily a ruthenium complex encounters and interacts with potential uptake sites. Along with the ligand environment, they help govern compatibility with binding sites, membranes, or solid surfaces. Comparing complexes with different charge or solubility provides a way to relate molecular properties to uptake efficiency and distribution.
Retention depends on the match between the ruthenium complex and the system’s available interaction sites. Binding-site chemistry, membrane interactions, surface adsorption, ligand exchange, and coordination-bond formation can all contribute. Considering these factors together helps distinguish simple association from more stable incorporation and clarifies why different systems distribute ruthenium differently.
A useful investigation considers the ruthenium complex’s oxidation state, ligand environment, charge, and solubility, then relates those features to binding sites, membranes, or solid surfaces. Researchers can use these relationships to interpret uptake efficiency, retention, distribution, and reactivity. The resulting chemical picture helps connect measured accumulation with possible coordination or adsorption pathways.
Studies of ruthenium uptake provide chemical context for designing catalysts, coordination compounds, and functional materials. They also support work on metal transport, sensing, separation, and metal-based therapeutic research by showing how ruthenium species interact with other systems. Understanding uptake can guide attention toward complex stability, surface adsorption, reaction pathways, or selective distribution.